Topics in medicinal chemistry, Год журнала: 2021, Номер unknown, С. 241 - 274
Опубликована: Янв. 1, 2021
Язык: Английский
Reaction Chemistry & Engineering, Год журнала: 2020, Номер 5(6), С. 1017 - 1052
Опубликована: Янв. 1, 2020
The progresses on continuous-flow organocatalysis from 2016 to early 2020 are reviewed with focus transition batch flow.
Язык: Английский
Процитировано
78
Russian Chemical Reviews, Год журнала: 2019, Номер 89(2), С. 225 - 249
Опубликована: Сен. 27, 2019
The results of studies on the application elemental phosphorus for synthesis important organophosphorus compounds are surveyed and summarized. Currently, this trend represents a synthetically, environmentally technologically attractive alternative to classical chemistry based toxic corrosive chlorides. Direct phosphination phosphinylation organic with (discussed in first part review) basically extend range available phosphines, phosphine chalcogenides phosphinic acids provides further development their synthetic potential second review). It is shown that breakthrough area largely due discovery reactions (white red) various electrophiles superbasic suspensions emulsions derived from alkali metal hydroxides electrochemical, electrocatalytic catalytic activation white phosphorus. bibliography includes 299 references.
Язык: Английский
Процитировано
45
The Chemical Record, Год журнала: 2023, Номер 23(10)
Опубликована: Май 23, 2023
Abstract The Ugi reaction has become one of the highly explored reactions for formation multifunctional adducts, due to mild conditions, wide scope and high variability. By carefully selecting starting four components, Ugi‐adducts could undergo different kinds post‐transformations synthesis bioactive heterocycles, natural products macrocycles. Considering significance polycycles, diverse post‐Ugi transformations have been developed over years constructing structurally novel polycycles. In this account, we summarize important efforts polycyclic N‐heterocycles via cyclizations from Van der Eycken laboratory onwards 2016. With aid transition metal catalysis gold, rhodium, silver palladium, as well metal‐free strategies, versatile polyheterocycles are prepared with efficiency step‐economy.
Язык: Английский
Процитировано
12
European Journal of Organic Chemistry, Год журнала: 2020, Номер 2020(33), С. 5236 - 5277
Опубликована: Апрель 27, 2020
Organophosphorus derivatives are widespread compounds that chemists find from the bench to plant, with numerous daily life applications. Besides their common utility for a wide range of notorious reactions such as Wittig and Horner‐Wadsworth‐Emmons olefinations, Arbuzov reaction, Staudinger Mitsunobu reaction well ligands large variety organometallic complexes, organophosphorus have also found applications active pharmaceutical ingredients agrochemicals. Some infamously known Chemical Warfare Agents. Within context generalized adoption new process technologies in Chemistry Toolbox, this review intends give an update on most recent significant advances continuous flow chemistry. Selected examples methodology, total synthesis preparation industrially relevant targets discussed illustrating assets
Язык: Английский
Процитировано
32
Organic Chemistry Frontiers, Год журнала: 2024, Номер 11(17), С. 4895 - 4912
Опубликована: Янв. 1, 2024
This review summarizes recent advances in the combination of Ugi-4CR and dearomatization for synthesis spirocycles.
Язык: Английский
Процитировано
4
The Journal of Organic Chemistry, Год журнала: 2019, Номер 84(21), С. 13935 - 13947
Опубликована: Сен. 19, 2019
The redox-neutral cascade dearomatization of indoles with o-aminobenzaldehydes has been realized via the hydride transfer strategy, achieving condition- and substrate-controlled divergent synthesis tetrahydroquinoline-fused spiroindolenines. integration transfer-involved C(sp3)–H functionalization provides a promising platform for construction structurally diverse molecules.
Язык: Английский
Процитировано
29
The Journal of Organic Chemistry, Год журнала: 2019, Номер 84(23), С. 15098 - 15105
Опубликована: Окт. 14, 2019
The first single electron transfer reductive deuteration of nitriles using D2O as a deuterium source has been developed for the synthesis valuable α,α-dideuterio amines. A mild reductant (SmI2) was employed donor with Et3N additive. This reaction is amenable to both aromatic and aliphatic features high incorporation, excellent regioselectivity, good functional group tolerance. synthetic utility this protocol demonstrated by series important deuterium-labeled building blocks medicinal chemistry agrochemistry applications.
Язык: Английский
Процитировано
26
Advanced Synthesis & Catalysis, Год журнала: 2019, Номер 362(1), С. 261 - 268
Опубликована: Ноя. 2, 2019
Abstract A silver(I) triflate‐catalyzed protocol for the post‐Ugi synthesis of tetracyclic spiroindolines has been developed. The worked best indole‐3‐carbaldehyde‐derived Ugi adducts obtained using anilines and 3‐aryl propiolic acids. Thus, it is complementary to previous cationic gold‐catalyzed procedure that was developed analogues substrates derived from aliphatic amines 3‐alkyl Furthermore, we have demonstrated under our new settings this domino Friedel‐Crafts ipso cyclization / imine trapping process could be efficiently combined with preceding four‐component reaction into a two‐step one‐pot transformation. magnified image
Язык: Английский
Процитировано
26
Chemistry of Materials, Год журнала: 2020, Номер 32(7), С. 2874 - 2883
Опубликована: Фев. 18, 2020
Metal nanoclusters are becoming exciting candidates as highly efficient catalysts for heterogeneous processes in view of their extraordinary surface to volume ratio and the high concentration uncoordinated atoms that contribute enhanced catalytic activity. For this reason, development accurate reliable procedures synthesis stable supported metal is desirable. Although Ag (Ag NCs) stabilized by anion templates with a structure like Agm+nm+ long lifetime have been widely investigated, clusters present significant advantages regarding recovery recyclability. In spite potential, stabilization precious metals on porous substrates scarcely investigated. Herein, we an innovative approach designed aim achieving strict control key phases such mixing, microwave heating, quenching. The catalyst was used activation alkynes showing excellent activity formation C–O, C–N, C–C bonds. When compared commonly homogeneous salts, NCs toward cyclization wide range substrates, thereby minimizing loading allowing separation well reuse multiple cycles.
Язык: Английский
Процитировано
25
Chemistry - A European Journal, Год журнала: 2020, Номер 27(4), С. 1165 - 1218
Опубликована: Июнь 30, 2020
Heteroarene-tethered functionalized alkynes are multipotent synthons in organic chemistry. This detailed Review described herein offers a thorough discussion of the metamorphosis heteroarene-tethered alkynes, an area which has earned much attention over past decade straightforward synthesis architecturally complex heterocyclic scaffolds atom and step economic manner. Depending upon variety this is divided into multiple sections. Amongst vast array synthetic transformations covered, dearomatizing spirocyclizations cascade spirocyclization/rearrangement great interest. Synthetic involving with scope, challenges, limitations, mechanism, their application total natural products future perceptions surveyed.
Язык: Английский
Процитировано
23