Nanomaterials,
Год журнала:
2024,
Номер
14(24), С. 2027 - 2027
Опубликована: Дек. 17, 2024
Cisplatin-based
platinum
compounds
are
important
clinical
chemotherapeutic
agents
that
participate
in
most
tumor
chemotherapy
regimens.
Through
density-functional
theory
calculations,
the
formation
and
stability
of
inorganic
oxide
carrier,
mechanisms
hydrolysis
reaction
activated
compound,
its
binding
mechanism
with
DNA
bases
can
be
studied.
The
higher
oxidation
state
Pt
(II
to
IV),
more
electrons
transfer
from
magnesia–gold
composite
material
compound.
After
adsorption
on
5d←2p
coordination
bonds
Pt-N
strengthened.
For
flat
oblique
modes
cisplatin,
there
is
no
significant
difference
density
states
gold
magnesium
film,
indicating
maintenance
heterojunction
structural
framework.
However,
changes
electronic
cisplatin
itself
different
configurations.
In
configuration,
band
gap
width
larger
than
configuration.
Cl-Pt
bond
range
Pt(III)
compound
shows
a
clear
charge
reduction
magnesia
an
active
site
potential
for
decomposition
hydrolysis.
substitution
chloride
ions
by
water
lead
products,
enhancing
polarization
showing
strong
separation.
free
endothermic
0.309
eV,
exceeding
small
activation
energy
barrier
0.399
this
easily
achievable.
ADME
(absorption,
distribution,
metabolism,
excretion)
prediction
parameters
indicate
products
have
good
ESOL
(Estimated
SOLubility)
solubility
high
gastrointestinal
absorption,
consistent
Lipinski’s
rule.
During
process,
distribution
frontier
molecular
orbitals,
HOMO
(highest
occupied
orbital)
initial
primarily
located
purine
base,
providing
possibility
electron
empty
orbitals
LUMO
(lowest
unoccupied
orbital).
HOMO-1
transition
product
mainly
distributed
orbital
rearrangement.
reduced
0.61
dipole
moment
gradually
decreases
6.77
Debye
during
reaction,
system’s
separation
polarization.
This
contribution
anticipated
provide
new
theoretical
clue
developing
carriers
compounds.
Molecules,
Год журнала:
2024,
Номер
29(13), С. 3121 - 3121
Опубликована: Июнь 30, 2024
The
cyclic
GMP-AMP
synthase
(cGAS)-stimulator
of
interferon
genes
(STING)
pathway
is
pivotal
in
immunotherapy.
Several
agonists
and
inhibitors
the
cGAS-STING
have
been
developed
evaluated
for
treatment
various
diseases.
aim
to
activate
STING,
with
dinucleotides
(CDNs)
being
most
common,
while
block
enzymatic
activity
or
DNA
binding
ability
cGAS.
Meanwhile,
non-CDN
compounds
cGAS
are
also
gaining
attention.
omnipresence
vivo
indicates
that
its
overactivation
could
lead
undesired
inflammatory
responses
autoimmune
diseases,
which
underscores
necessity
developing
both
pathway.
This
review
describes
molecular
traits
roles
summarizes
development
inhibitors.
information
supposed
be
conducive
design
novel
drugs
targeting
Angewandte Chemie International Edition,
Год журнала:
2024,
Номер
63(37)
Опубликована: Май 22, 2024
Though
platinum
(Pt)-based
complexes
have
been
recently
exploited
as
immunogenic
cell
death
(ICD)
inducers
for
activating
immunotherapy,
the
effective
activation
of
sufficient
immune
responses
with
minimal
side
effects
in
deep-seated
tumors
remains
a
formidable
challenge.
Herein,
we
propose
first
example
near-infrared
(NIR)
light-activated
and
lysosomal
targeted
Pt(II)
metallacycle
(1)
supramolecular
ICD
inducer.
1
synergistically
potentiates
immunomodulatory
response
via
multiple-regulated
approaches,
involving
NIR
light
excitation,
boosted
reactive
oxygen
species
(ROS)
generation,
good
selectivity
between
normal
tumor
cells,
enhanced
penetration/retention
capabilities.
Specifically,
has
excellent
depth-activated
ROS
production
(~7
mm),
accompanied
by
strong
anti-diffusion
anti-ROS
quenching
ability.
In
vitro
experiments
demonstrate
that
exhibits
significant
cellular
uptake
generation
cells
well
respective
multicellular
spheroids.
Based
on
these
advantages,
induces
more
efficient
an
ultralow
dose
(i.e.,
5
μM)
compared
clinical
inducer-oxaliplatin
(300
μM).
vivo,
vaccination
further
serves
potent
inducer
through
eliciting
CD8
Journal of Medicinal Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 31, 2025
Chemoimmunotherapy
is
an
alternative
treatment
against
cancers.
Platinum(IV)
complexes
FMP
and
DFMP,
coupling
formononetin
derivative
as
axial
ligand(s),
were
designed
to
suppress
triple-negative
breast
cancer
(TNBC)
by
activating
death
receptors
(DRs)
natural
killer
(NK)
cells.
These
show
great
potential
overcome
the
resistance
of
TNBC
chemotherapy
inducing
both
intrinsic
extrinsic
apoptosis
in
Particularly,
with
one
not
only
induced
caspase-3-dependent
but
also
upregulated
expression
DRs
caspase-8,
triggered
apoptosis,
enhanced
cytotoxic
ability
NK92
Moreover,
increased
release
granzyme
B,
restrained
proliferation
differentiation
myeloid-derived
suppressor
cells,
secretion
IL-10,
thus
inhibiting
vitro
vivo.
The
results
demonstrate
that
overcomes
chemoresistance
immune
escape
through
a
new
mechanism
involving
synergy
immunotherapy.
Kragujevac Journal of Science,
Год журнала:
2024,
Номер
46(1), С. 73 - 84
Опубликована: Янв. 1, 2024
The
newly
developed
mononuclear
5,6-epoxy-5,6-dihydro-1,10phenanthroline
platinum(II)
complex
revealed
notable
antitumor
effects
in
vitro
and
vivo.
In
this
study,
the
of
on
immune
response
were
assessed.
Peritoneal
macrophages
splenocytes
obtained
from
mice
treated
with
lipopolysaccharide
(LPS)/Concanavalin
A
(ConA)
along
measurement
cytokine
concentrations
immunophenotyping
was
performed.
Our
findings
indicate
that
exhibits
significant
immunomodulatory
peritoneal
splenocytes.
Angewandte Chemie,
Год журнала:
2024,
Номер
136(37)
Опубликована: Май 22, 2024
Abstract
Though
platinum
(Pt)‐based
complexes
have
been
recently
exploited
as
immunogenic
cell
death
(ICD)
inducers
for
activating
immunotherapy,
the
effective
activation
of
sufficient
immune
responses
with
minimal
side
effects
in
deep‐seated
tumors
remains
a
formidable
challenge.
Herein,
we
propose
first
example
near‐infrared
(NIR)
light‐activated
and
lysosomal
targeted
Pt(II)
metallacycle
(
1
)
supramolecular
ICD
inducer.
synergistically
potentiates
immunomodulatory
response
via
multiple‐regulated
approaches,
involving
NIR
light
excitation,
boosted
reactive
oxygen
species
(ROS)
generation,
good
selectivity
between
normal
tumor
cells,
enhanced
penetration/retention
capabilities.
Specifically,
has
excellent
depth‐activated
ROS
production
(~7
mm),
accompanied
by
strong
anti‐diffusion
anti‐ROS
quenching
ability.
In
vitro
experiments
demonstrate
that
exhibits
significant
cellular
uptake
generation
cells
well
respective
multicellular
spheroids.
Based
on
these
advantages,
induces
more
efficient
an
ultralow
dose
(i.e.,
5
μM)
compared
clinical
inducer‐oxaliplatin
(300
μM).
vivo
,
vaccination
further
serves
potent
inducer
through
eliciting
CD8
+
/CD4
T
Foxp3
depletion
negligible
adverse
effects.
This
study
pioneers
promising
avenue
safe
metal‐based
agents
immunotherapy.
