Direct C(sp3)-H functionalization with aryl and alkyl radicals as intermolecular hydrogen atom transfer (HAT) agents
Chemical Communications,
Год журнала:
2024,
Номер
unknown
Опубликована: Янв. 1, 2024
Recent
years
have
witnessed
the
emergence
of
direct
intermolecular
C(sp
Язык: Английский
Photoinduced Cascade Synthesis of Oxindoles and Isoquinolinediones
The Journal of Organic Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 19, 2025
Herein,
we
developed
alkyl
radical
generation
from
C(sp3)–H
bonds
of
alkanes
via
a
photoinduced
HAT-process
without
employing
an
external
metal,
photocatalyst,
and
organic
peroxide.
The
generated
participates
in
addition
cascade
cyclization
N-arylacrylamides/N-acryloyl
benzamides
to
deliver
structurally
diverse
valuable
functionalized
oxindoles
isoquinolinediones
moderate
good
yields.
Preliminary
mechanistic
studies
indicated
the
aryl
through
homolytic
cleavage
Ar–I
direct
photoexcitation
iodide.
Язык: Английский
Visible‐Light Enabled Synthesis of 1‐Aryl‐3‐Sulfonylmethyl‐1,2,4‐Triazoles by Arylazo Sulfones
Advanced Synthesis & Catalysis,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 5, 2024
Abstract
We
present
a
novel
and
highly
efficient
method
for
synthesizing
polyfunctionalized
1,2,4‐triazoles.
This
approach
leverages
visible
light
arylazo
sulfones
in
combination
with
N
‐vinyl
amides,
the
environmentally
friendly
solvent
ethyl
acetate.
Remarkably,
reaction
proceeds
without
need
(photo)catalysts,
ensuring
near‐perfect
atom
economy
producing
only
water
as
by‐product.
exhibits
excellent
functional
group
tolerance
can
be
scaled
both
batch
continuous‐flow
processes.
Язык: Английский