Electro‐Synthesis of Organic Compounds with Heterogeneous Catalysis

Advanced Science, Год журнала: 2022, Номер 10(1)

Опубликована: Ноя. 18, 2022

Electro-organic synthesis has attracted a lot of attention in pharmaceutical science, medicinal chemistry, and future industrial applications energy storage conversion. To date, there not been detailed review on electro-organic with the strategy heterogeneous catalysis. In this review, most recent advances synthesizing value-added chemicals by catalysis are summarized. An overview electrocatalytic oxidation reduction processes as well paired electrocatalysis is provided, anodic alcohols (monohydric polyhydric), aldehydes, amines discussed. This also provides in-depth insight into cathodic carboxylates, carbon dioxide, CC, C≡C, reductive coupling reactions. Moreover, electro-synthesis methods, including parallel paired, sequential divergent convergent electrolysis, Additionally, strategies developed to achieve high electrosynthesis efficiency associated challenges addressed. It believed that promising direction organic electrochemistry, offering numerous opportunities develop new reaction methods.

Язык: Английский

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Chloride‐Promoted Photoelectrochemical C—H Silylation of Heteroarenes^†

Chinese Journal of Chemistry, Год журнала: 2023, Номер 41(22), С. 2963 - 2968

Опубликована: Июнь 24, 2023

Comprehensive Summary A photoelectrochemical approach for the C—H silylation of heteroarenes through dehydrogenation cross‐coupling with H 2 evolution has been developed. The depends on hydrogen atom transfer (HAT) from silanes to Cl‐radical generated light‐induced homolytic cleavage Cl , in which was produced by electrochemical oxidation chloride. large number silylated heterocyclic molecules are rapidly constructed satisfactory yields without relying oxidants and metal reagents.

Язык: Английский

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Electrocatalytic synthesis: an environmentally benign alternative for radical-mediated aryl/alkenyl C(sp²)–C(sp³) cross-coupling reactions

Green Chemistry, Год журнала: 2022, Номер 24(24), С. 9373 - 9401

Опубликована: Янв. 1, 2022

This review covers the recent progress in electrochemically enabled radical-mediated aryl/alkenyl C(sp 2 )–C(sp 3 ) cross-coupling reactions, including synthetic strategies, plausible mechanisms and further research outlook.

Язык: Английский

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Electrochemical oxidation-induced benzylic C(sp³)–H functionalization towards the atom-economic synthesis of oxazole heterocycles

Green Chemistry, Год журнала: 2023, Номер 25(13), С. 5128 - 5133

Опубликована: Янв. 1, 2023

A unique electrochemical four-component reaction of terminal alkynes, (thio)xanthenes, nitriles, and water has been established in the absence any catalyst or external oxidant.

Язык: Английский

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Catalyst-free benzylic C(sp³)–H cross-coupling with organotrifluoroborates enabled by electrochemistry

Green Chemistry, Год журнала: 2022, Номер 24(20), С. 7883 - 7888

Опубликована: Янв. 1, 2022

An electrochemical benzylic C(sp 3 )–H cross-coupling with organotrifluoroborates without any catalyst or external electrolyte has been developed.

Язык: Английский

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Recent Advances in the Electrochemical Functionalization of Isocyanides

The Chemical Record, Год журнала: 2022, Номер 23(1)

Опубликована: Сен. 20, 2022

Abstract Isocyanides are well‐known as efficient CO surrogates and C1 synthons in modern organic synthesis. Although tremendous efforts have been devoted to fully exploiting the reactivity of isocyanides, these transformations primarily limited by their utilization stoichiometric toxic chemical oxidants. With recent resurgence electrochemistry, which has considerably laid dormant over past several decades, electrolysis identified a green powerful tool enrich structural diversity solely utilizing electric current clean inherently safe redox equivalents In this regard, unique isocyanides studied numerous electrochemical transformations. This review comprehensively highlights most relevant progress strategies towards functionalization up until June 2022, with focus on reaction outcomes mechanisms.

Язык: Английский

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Electrochemical Reduction of Benzo[b]thiophene 1,1‐Dioxides with HFIP as Hydrogen Donor^†

Chinese Journal of Chemistry, Год журнала: 2023, Номер 42(6), С. 585 - 591

Опубликована: Ноя. 2, 2023

Comprehensive Summary A straightforward electrochemical reduction of benzo[ b ]thiophene 1,1‐dioxides with HFIP as the hydrogen donor has been reported in an undivided cell under metal‐free conditions. Moreover, tolerance various functional groups and scaled‐up experiments showed practicability potential applications this methodology.

Язык: Английский

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Sustainable Approaches for the Synthesis of Functionalized Xanthene Derivatives with Anticancer Activities Using Modern Green Tools at Room Temperature: Less Energy and More Efficiency

Synlett, Год журнала: 2025, Номер unknown

Опубликована: Апрель 30, 2025

Abstract Functionalized xanthenes occupy an important position in medicinal chemistry due to their wide range of pharmacological properties. The xanthene skeleton is present various bioactive natural products such as mulgravanols A and B, hermannol, (+)-myrtucommulone D, homapanicones blumeaxanthene II, acrotrione, etc. Important xanthene-based drugs, including propantheline bromide, methantheline, phloxine etc., are available on the market. Thus, much effort has been dedicated generating or modifying crucial O-heterocyclic compounds. Recently, development efficient processes for synthesis derivatives using modern techniques received significant attention overcome disadvantages traditional methodologies. Aligned with sixth principle green chemistry, which minimum energy needed perform synthetic methods at ambient temperature optimum productivity, this account focuses green, room-temperature strategies anticancer activities 1 Introduction 2 Synthesis Xanthene Derivatives through Green Strategies Room Temperature 3 Medicinal Perspectives Anticancer Agents 4 Conclusion 5 List Abbreviations

Язык: Английский

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Ferrocene as a Redox Catalyst for Organic Electrosynthesis

Israel Journal of Chemistry, Год журнала: 2023, Номер 64(1-2)

Опубликована: Авг. 23, 2023

Abstract Despite substantial advancements in thermal and photochemical catalysis, the evolution of similar processes within realm organic electrochemistry has seen a slower pace. However, recent years have heralded remarkable surge molecular electrocatalysis. This innovative technique harnesses power catalysts to expedite electrochemical transformations. article underscores application ferrocene (Fc) as redox catalyst electrosynthesis. It delves into extensive utilization Fc electrosynthesis, particularly emphasizing its role electrocatalytic generation reactions heteroatom‐ carbon‐centered radicals, among various other reactions.

Язык: Английский

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An Electrocatalytic Strategy for Dehydrogenative [4 + 2] Cycloaddition over a Cobalt‐Based Catalyst

Chinese Journal of Chemistry, Год журнала: 2022, Номер 40(23), С. 2741 - 2746

Опубликована: Авг. 17, 2022

Comprehensive Summary Exploring the anodic reaction to substitute conventional oxygen evolution (OER) for synthesis of complex pharmaceutical molecules is highly attractive. Here, we report an electrocatalytic strategy dehydrogenative [4 + 2] cycloaddition N , ‐dialkylanilines with maleimides via dual functionalization both C(sp 3 )‐H and 2 bonds, by using electrochemically activated cobalt carbonate hydroxide hydrate supported on carbon cloth (CCHH‐A/CC), affording various tetrahydroquinolines high yields. This electrochemical transformation proceeds activity stability, as well good substrate compatibility. Mechanism study shows that α‐aminoalkyl radical exists in electrooxidation reaction. significant potential valuable chemicals strategy.

Язык: Английский

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