Cell Reports Physical Science,
Год журнала:
2024,
Номер
5(8), С. 102132 - 102132
Опубликована: Авг. 1, 2024
Alkynes
are
key
motifs
in
chemistry,
serving
as
precursors
many
organic
reactions
toward
the
synthesis
of
bioactive
compounds,
polymers,
and
new
materials.
Methods
to
synthesize
terminal
alkynes
with
an
extension
carbon
skeleton
involve
harsh
and/or
dangerous
reagents.
Further
derivatization
diaryl
largely
relies
on
popular
Sonogashira
coupling.
This
cross-coupling
uses
expensive
Pd
catalysts,
phosphine
ligands,
toxic
Cu
co-catalysts.
Herein,
we
report
a
one-pot
approach
under
transition-metal-free
conditions
from
feedstock
chemicals
(toluenes
methyl
benzoates).
is
also
applicable
preparation
conjugated
1,3-enynes
single
flask.
The
disclosed
methods
expected
be
complementary
state-of-the-art
by
streamlining
alkynes,
reducing
costs
production
these
valuable
building
blocks,
increasing
sustainability
alkynes.
ACS Catalysis,
Год журнала:
2024,
Номер
14(5), С. 3278 - 3286
Опубликована: Фев. 15, 2024
Herein,
we
reported
the
enantioconvergent
Csp3–Csp2
cross-coupling
reaction
with
1,4-dihydropyridine
(DHP)
derivatives
via
photoredox/nickel
dual
catalysis
to
access
chiral
products
good
yield
and
enantioselectivity.
The
operationally
simple
was
carried
out
under
mild
conditions
functional
group
tolerance.
Due
use
of
a
stoichiometric
equivalent
aryl/alkenyl
halides
as
coupling
partners,
sequential
iterative
synthesis
could
be
achieved
smoothly
in
one
pot
for
position
isomers
stereoisomers.
In
proposed
mechanism,
kinetic
experiments
mechanistic
studies
indicated
that
radical
generation,
depended
on
excited
photocatalyst
DHP,
rate-determining
step.
Chinese Journal of Chemistry,
Год журнала:
2023,
Номер
41(23), С. 3189 - 3196
Опубликована: Июль 11, 2023
Comprehensive
Summary
Based
on
characteristics
of
the
tumor
microenvironment
(TME),
including
acidity,
hypoxia,
inflammation
and
hydrogen
peroxide
overload,
combined
with
emerging
nanotechnologies,
designing
nanoplatforms
TME
specificity/responsiveness
for
treatment
is
a
promising
nanotherapeutic
strategy.
In
this
work,
multifunctional
gold‐palladium
bimetallic
cascade
nanozyme
was
constructed
effective
photothermal‐enhanced
catalyzed
synergistic
therapy
tumors.
The
dumbbell‐like
Au‐Pd
nanomaterial
(Au
NRs‐Pd@HA)
obtained
by
reducing
palladium
gold
nanorods
ascorbic
acid
(AA)
further
modified
hyaluronic
(HA).
introduction
HA
brings
biocompatibility
targeting
properties.
zebrafish
embryos
model
showed
that
Au
NRs‐Pd@HA
had
good
low
biotoxicity.
can
induce
catalytic
conversion
glucose
to
generate
H
2
O
efficiently,
subsequently
undergo
reaction
produce
abundant
·OH
radicals,
exhibiting
peroxidase‐like
(POD‐like)
oxidase‐like
(GOD‐like)
capabilities.
generated
key
factor
ablation.
Meanwhile,
exhibits
photothermal
performance
under
808
nm
irradiation,
in
favor
(PTT).
Especially,
POD‐like
GOD‐like
activities
were
significantly
enhanced
due
effect.
PTT
nanozymes
effect
enabled
efficient
safe
cancer
therapy.
Advanced Synthesis & Catalysis,
Год журнала:
2024,
Номер
366(11), С. 2382 - 2431
Опубликована: Апрель 12, 2024
Abstract
This
contribution
offers
a
comprehensive
overview
of
methods
for
forging
sp
C−Si
bonds.
Over
time,
alkynylsilanes
(silylacetylenes),
once
considered
mere
byproducts
hydrosilylation
processes,
have
become
essential
building
blocks
in
organic
synthesis.
literature
review
traces
the
evolution
their
synthesis,
from
traditional
methodologies
relying
on
organolithium
and
organomagnesium
compounds
to
more
advanced
cross‐coupling
reactions
involving
hydro‐
carbosilanes.
Focused
primarily
past
25
years
(2000–2024),
it
also
extensively
references
significant
historical
breakthroughs.
By
analyzing
synthetic
methodologies,
not
only
survey
current
state
knowledge
but
identifies
areas
improvement.
Furthermore,
emphasize
importance
1‐alkynylsilanes
(1‐silyl‐1‐alkynes),
selected
applications
these
are
highlighted,
confirming
potential
Chemical Communications,
Год журнала:
2023,
Номер
59(78), С. 11615 - 11630
Опубликована: Янв. 1, 2023
This
review
briefly
summarizes
the
developments
in
photochemical
Sonogashira-coupling
reactions.
It
especially
highlights
underlying
mechanisms
for
formation
of
C–C
bond
and
photocatalyst
evolution
towards
sustainability.
Organic & Biomolecular Chemistry,
Год журнала:
2024,
Номер
22(31), С. 6215 - 6245
Опубликована: Янв. 1, 2024
Use
of
organosulphur
and
organoselenium
compounds
in
the
development
homogeneous,
heterogeneous
nanocatalytic
systems
for
Sonogashira
coupling
reactions.
Molecules,
Год журнала:
2024,
Номер
29(22), С. 5265 - 5265
Опубликована: Ноя. 7, 2024
Sequential
Pd-catalyzed
one-pot
synthetic
methodologies
have
emerged
as
a
powerful
and
versatile
approach
in
organic
synthesis,
enabling
the
construction
of
complex
heterocyclic
architectures
with
high
efficiency,
selectivity,
atom
economy.
This
review
discusses
key
advancements
multistep,
sequentially
processes
for
accessing
derivatives,
focusing
on
classic
reactions
like
Suzuki-Miyaura,
Sonogashira,
Heck,
hydroamination
extending
to
specialized
techniques
such
directed
C-H
activation.
The
concatenation
these
steps
has
advanced
scope
strategies.
A
section
is
dedicated
exploring
cooperative
use
palladium
other
metals,
particularly
copper,
ruthenium,
gold,
which
broadened
range
accessible
derivatives.
Highlighted
applications
include
synthesis
biologically
pharmaceutically
relevant
compounds,
tris(hetero)aryl
systems,
spiro-oxindoles,
indole
These
strategies
not
only
streamline
but
also
align
green
chemistry
principles
by
minimizing
purification
reducing
waste
energy
consumption.
addresses
current
challenges
limitations
methodologies,
offering
insights
into
ongoing
efforts
optimize
reaction
conditions
expand
applicability
sequential
processes.
Organic reactions,
Год журнала:
2025,
Номер
unknown, С. 1 - 1149
Опубликована: Янв. 3, 2025
Conjugated
alkynes
are
valuable
intermediates
in
the
synthesis
of
natural
products,
agrochemicals,
pharmaceuticals,
fine
chemicals,
and
organic
molecular
materials.
Since
its
introduction
1975,
palladium‐catalyzed
Sonogashira
reaction
has
become
primary
choice
for
construction
sp–sp
2
carbon–carbon
bonds
aryl‐,
heteroaryl‐,
alkenyl‐substituted
alkynes.
A
vast
range
conditions
have
been
explored
to
expand
optimize
scope
reaction,
including
sustainable
variants,
microwave‐assisted
cross
couplings,
couplings
performed
water.
Research
efforts
also
target
development
improved
catalytic
systems
such
as
solid‐supported
palladium
catalysts
nanoparticles,
use
N
‐heterocyclic
carbenes
(NHCs)
ligands,
well
copper‐free
variants
reaction.
This
Chapter
reviews
application
coupling
terminal
with
aryl
or
alkenyl
halides
triflates.
Coupling
reactions
that
form
conjugated
via
alternative
methods,
different
electrophiles,
catalysts,
alkynes,
briefly
described.
