The Journal of Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
89(7), P. 5010 - 5018
Published: March 27, 2024
Recent
years
have
seen
novel
modalities
emerge
for
the
treatment
of
human
diseases
resulting
in
an
increase
beyond
rule
5
(bRo5)
chemical
matter.
As
a
result,
synthetic
innovations
aiming
to
enable
rapid
access
complex
bRo5
molecular
entities
become
increasingly
valuable
medicinal
chemists'
toolkits.
Herein,
we
report
general
synthesis
new
class
noncanonical
amino
acids
(ncAA)
with
cyclopropyl
backbone
achieve
conformational
constraint
and
bearing
C(sp3)-rich
benzene
bioisosteres.
We
also
demonstrate
preliminary
studies
toward
utilities
these
ncAA
as
building
blocks
chemistry
research.
ACS Catalysis,
Journal Year:
2024,
Volume and Issue:
14(5), P. 3278 - 3286
Published: Feb. 15, 2024
Herein,
we
reported
the
enantioconvergent
Csp3–Csp2
cross-coupling
reaction
with
1,4-dihydropyridine
(DHP)
derivatives
via
photoredox/nickel
dual
catalysis
to
access
chiral
products
good
yield
and
enantioselectivity.
The
operationally
simple
was
carried
out
under
mild
conditions
functional
group
tolerance.
Due
use
of
a
stoichiometric
equivalent
aryl/alkenyl
halides
as
coupling
partners,
sequential
iterative
synthesis
could
be
achieved
smoothly
in
one
pot
for
position
isomers
stereoisomers.
In
proposed
mechanism,
kinetic
experiments
mechanistic
studies
indicated
that
radical
generation,
depended
on
excited
photocatalyst
DHP,
rate-determining
step.
Chinese Journal of Chemistry,
Journal Year:
2023,
Volume and Issue:
41(23), P. 3189 - 3196
Published: July 11, 2023
Comprehensive
Summary
Based
on
characteristics
of
the
tumor
microenvironment
(TME),
including
acidity,
hypoxia,
inflammation
and
hydrogen
peroxide
overload,
combined
with
emerging
nanotechnologies,
designing
nanoplatforms
TME
specificity/responsiveness
for
treatment
is
a
promising
nanotherapeutic
strategy.
In
this
work,
multifunctional
gold‐palladium
bimetallic
cascade
nanozyme
was
constructed
effective
photothermal‐enhanced
catalyzed
synergistic
therapy
tumors.
The
dumbbell‐like
Au‐Pd
nanomaterial
(Au
NRs‐Pd@HA)
obtained
by
reducing
palladium
gold
nanorods
ascorbic
acid
(AA)
further
modified
hyaluronic
(HA).
introduction
HA
brings
biocompatibility
targeting
properties.
zebrafish
embryos
model
showed
that
Au
NRs‐Pd@HA
had
good
low
biotoxicity.
can
induce
catalytic
conversion
glucose
to
generate
H
2
O
efficiently,
subsequently
undergo
reaction
produce
abundant
·OH
radicals,
exhibiting
peroxidase‐like
(POD‐like)
oxidase‐like
(GOD‐like)
capabilities.
generated
key
factor
ablation.
Meanwhile,
exhibits
photothermal
performance
under
808
nm
irradiation,
in
favor
(PTT).
Especially,
POD‐like
GOD‐like
activities
were
significantly
enhanced
due
effect.
PTT
nanozymes
effect
enabled
efficient
safe
cancer
therapy.
Advanced Synthesis & Catalysis,
Journal Year:
2024,
Volume and Issue:
366(11), P. 2382 - 2431
Published: April 12, 2024
Abstract
This
contribution
offers
a
comprehensive
overview
of
methods
for
forging
sp
C−Si
bonds.
Over
time,
alkynylsilanes
(silylacetylenes),
once
considered
mere
byproducts
hydrosilylation
processes,
have
become
essential
building
blocks
in
organic
synthesis.
literature
review
traces
the
evolution
their
synthesis,
from
traditional
methodologies
relying
on
organolithium
and
organomagnesium
compounds
to
more
advanced
cross‐coupling
reactions
involving
hydro‐
carbosilanes.
Focused
primarily
past
25
years
(2000–2024),
it
also
extensively
references
significant
historical
breakthroughs.
By
analyzing
synthetic
methodologies,
not
only
survey
current
state
knowledge
but
identifies
areas
improvement.
Furthermore,
emphasize
importance
1‐alkynylsilanes
(1‐silyl‐1‐alkynes),
selected
applications
these
are
highlighted,
confirming
potential
Organic reactions,
Journal Year:
2025,
Volume and Issue:
unknown, P. 1 - 1149
Published: Jan. 3, 2025
Conjugated
alkynes
are
valuable
intermediates
in
the
synthesis
of
natural
products,
agrochemicals,
pharmaceuticals,
fine
chemicals,
and
organic
molecular
materials.
Since
its
introduction
1975,
palladium‐catalyzed
Sonogashira
reaction
has
become
primary
choice
for
construction
sp–sp
2
carbon–carbon
bonds
aryl‐,
heteroaryl‐,
alkenyl‐substituted
alkynes.
A
vast
range
conditions
have
been
explored
to
expand
optimize
scope
reaction,
including
sustainable
variants,
microwave‐assisted
cross
couplings,
couplings
performed
water.
Research
efforts
also
target
development
improved
catalytic
systems
such
as
solid‐supported
palladium
catalysts
nanoparticles,
use
N
‐heterocyclic
carbenes
(NHCs)
ligands,
well
copper‐free
variants
reaction.
This
Chapter
reviews
application
coupling
terminal
with
aryl
or
alkenyl
halides
triflates.
Coupling
reactions
that
form
conjugated
via
alternative
methods,
different
electrophiles,
catalysts,
alkynes,
briefly
described.
Chemical Communications,
Journal Year:
2023,
Volume and Issue:
59(78), P. 11615 - 11630
Published: Jan. 1, 2023
This
review
briefly
summarizes
the
developments
in
photochemical
Sonogashira-coupling
reactions.
It
especially
highlights
underlying
mechanisms
for
formation
of
C–C
bond
and
photocatalyst
evolution
towards
sustainability.
Organic Letters,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 4, 2025
The
palladium-catalyzed
Sonogashira
cross-coupling
of
(hetero)aryl
fluorosulfates
and
terminal
alkynes,
featuring
a
synthetically
useful
scope
yields,
is
reported
herein.
Such
transformations
involving
diversity
fluorosulfate
coupling
partners,
including
chemoselective
examples
where
contending
chloro
functionalities
are
present,
achieved
using
DPPF/[Pd(cinnamyl)Cl]2
catalyst
system
without
the
requirement
copper
additive.
