DNAzyme-Based Dissipative DNA Strand Displacement for Constructing Temporal Logic Gates

ACS Nano, Год журнала: 2024, Номер 18(3), С. 2184 - 2194

Опубликована: Янв. 9, 2024

Toehold-mediated DNA strand displacement is the foundation of dynamic nanotechnology, encompassing a wide range tools with diverse functions, dynamics, and thermodynamic properties. However, majority these are limited to unidirectional reactions driven by thermodynamics. In response growing field dissipative we present an approach: DNAzyme-based (D-DSD), which combines principles nanotechnology nanotechnology. D-DSD introduces circular characteristics, distinguishing it from observed in conventional displacement. We investigated reaction mechanism devised temporal control elements. By substituting components, designed two distinct AND gates using fewer than 10 strands, eliminating need for complex network designs. contrast previous logic gates, our storage not through dynamics or cross-inhibition but autoregressive storage, more modular scalable approach memory storage. preserves fundamental structure toehold-mediated displacement, while offering enhanced simplicity versatility.

Язык: Английский

Improving Dynamic Control of Toehold-Mediated Strand Displacement Reactions through Phosphorothioate Modifications

Nanoscale, Год журнала: 2024, Номер unknown

Опубликована: Янв. 1, 2024

The discovery for the first time that phosphorothioate modifications can enhance rate of TMSD in short toehold region. Furthermore, we applied our findings to CHA circuits and DNA probabilistic circuits.

Язык: Английский