Ru(II)‐Catalyzed Selective C—H Alkynylation of Isoquinolones, Quinazolones and Phthalazinones with Bromoalkynes
Chinese Journal of Chemistry,
Год журнала:
2024,
Номер
42(15), С. 1686 - 1690
Опубликована: Март 15, 2024
Comprehensive
Summary
A
new,
selective
Ru(II)‐catalyzed
alkynylation
reaction
of
isoquinolones,
quinazolones
and
phthalazinones
with
readily
available
bromoalkynes
has
been
developed.
This
enables
the
construction
a
new
C(sp
2
)‐C(sp)
bond
through
C—H
activation
C—Br
functionalization,
offers
an
effective
route
to
synthesizing
highly
valuable
alkynylated
isoquinolone,
quinazolone
phthalazinone
derivatives
wide
substrate
scope
high
selectivity.
Язык: Английский
Ru(II)-Catalyzed C–H Amination of 1,2,3-Benzotriazinones with Azide Compounds
The Journal of Organic Chemistry,
Год журнала:
2024,
Номер
89(17), С. 12249 - 12254
Опубликована: Авг. 8, 2024
A
Ru(II)-catalyzed
directed
C–H
amination
of
1,2,3-benzotriazinones
with
azide
compounds
has
been
reported.
The
reaction
a
wide
substrate
scope
organic
azides
good
results
and
represents
useful
pathway
to
the
construction
versatile
heterocyclic
amino
products.
In
addition,
method
can
be
used
for
phthalazinones,
highlighting
synthetic
practicability
strategy.
Язык: Английский
Recent approaches for the synthesis of heterocycles from amidines via metal catalyzed C-H functionalization reaction
Organic & Biomolecular Chemistry,
Год журнала:
2024,
Номер
22(25), С. 5014 - 5031
Опубликована: Янв. 1, 2024
Transition
metal
catalyzed
C-H
bond
activation
has
become
one
of
the
most
important
tools
for
constructing
new
chemical
bonds.
Introducing
directing
groups
to
substrates
is
key
a
successful
reaction,
these
can
also
be
further
transformed
in
reaction.
Amidines
with
their
unique
structure
and
reactivity
are
ideal
transition
metal-catalyzed
transformations.
This
review
describes
major
advances
mechanistic
investigations
activation/annulation
tandem
reactions
amidines
until
early
2024,
focusing
on
unsaturated
compounds,
such
as
alkynes,
ketone,
vinylene
carbonate,
cyclopropanols
derivatives.
Meanwhile
this
manuscript
explores
reaction
different
carbene
precursors,
example
diazo
azide,
triazoles,
pyriodotriazoles,
sulfoxonium
ylides
well
own
activation/cyclization
reactions.
A
bright
outlook
provided
at
end
manuscript.
Язык: Английский
Co(III) or Ru(II)-Catalyzed Selective C–H Alkynylation of 2-Pyridones and Their Derivatives with Bromoalkynes
The Journal of Organic Chemistry,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 5, 2024
We
successfully
reported
selective
C–H
alkynylation
of
2-pyridones
with
bromoalkynes
under
the
catalysis
Co(III)
or
Ru(II).
The
reaction
used
easily
accessible
instead
high-valent
iodine
alkynes.
There
is
a
broad
substrate
scope
good
yields.
In
addition,
2-pyridone
can
be
as
weakly
directing
group
for
proximal
aryl
bond.
This
method
offers
an
efficient
approach
synthesizing
diverse
derivatives,
yielding
alkynylated
products
up
to
95%
yield
(>40
examples).
Язык: Английский