Transient Directing Group-Assisted Palladium-Catalyzed C4-Alkynylation of Indoles
The Journal of Organic Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 10, 2025
Pd-catalyzed
C4-selective
alkynylation
of
indoles
was
established
by
employing
glycine
as
a
transient
directing
group.
This
reaction
exhibits
high
regioselectivity
with
the
tolerance
wide
scope
functional
groups
to
afford
diverse
alkynylated
in
moderate
good
yields.
Moreover,
readily
accessible
scale-up
synthesis
and
further
decorations
achieve
multifunctionalized
demonstrate
synthetic
potential
this
protocol.
Язык: Английский
Ru(II)-Catalyzed C–H Amination of 1,2,3-Benzotriazinones with Azide Compounds
The Journal of Organic Chemistry,
Год журнала:
2024,
Номер
89(17), С. 12249 - 12254
Опубликована: Авг. 8, 2024
A
Ru(II)-catalyzed
directed
C–H
amination
of
1,2,3-benzotriazinones
with
azide
compounds
has
been
reported.
The
reaction
a
wide
substrate
scope
organic
azides
good
results
and
represents
useful
pathway
to
the
construction
versatile
heterocyclic
amino
products.
In
addition,
method
can
be
used
for
phthalazinones,
highlighting
synthetic
practicability
strategy.
Язык: Английский
Co(III) or Ru(II)-Catalyzed Selective C–H Alkynylation of 2-Pyridones and Their Derivatives with Bromoalkynes
The Journal of Organic Chemistry,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 5, 2024
We
successfully
reported
selective
C–H
alkynylation
of
2-pyridones
with
bromoalkynes
under
the
catalysis
Co(III)
or
Ru(II).
The
reaction
used
easily
accessible
instead
high-valent
iodine
alkynes.
There
is
a
broad
substrate
scope
good
yields.
In
addition,
2-pyridone
can
be
as
weakly
directing
group
for
proximal
aryl
bond.
This
method
offers
an
efficient
approach
synthesizing
diverse
derivatives,
yielding
alkynylated
products
up
to
95%
yield
(>40
examples).
Язык: Английский