Recent advances in the synthesis of trifluoromethyl-containing heterocyclic compounds via trifluoromethyl building blocks

Organic & Biomolecular Chemistry, Год журнала: 2024, Номер 22(31), С. 6246 - 6276

Опубликована: Янв. 1, 2024

Recent advances in the preparation of trifluoromethyl-containing heterocyclics via trifluoromethyl building block strategies over period from 2019 to present are systematically summarized and discussed.

Язык: Английский

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Combining (CH₂O)_n and (NH₄)₂CO₃ as a Formamidine Equivalent for “Four-in-One” Synthesis of Fluoroalkylated 2-H-Pyrimidines

Organic Letters, Год журнала: 2024, Номер 26(33), С. 7078 - 7082

Опубликована: Авг. 9, 2024

Multicomponent reactions hold the potential to maximize synthetic efficiency in preparation of diverse and complex molecular scaffolds. An unprecedented formal [3+1+1+1] annulation approach for one-step synthesis fluoroalkylated 2-H-pyrimidines commencing from perfluoroalkyl alkenes, paraformaldehyde, ammonium carbonate is described. By harnessing readily accessible (CH2O)n cheap (NH4)2CO3 as a formamidine surrogate, this method effectively replaces traditionally preformed amidines with pyrimidine assembly. The multicomponent reaction proceeds step-economical, operationally simple, metal-free, additive-free manner, featuring broad substrate scope, excellent functional group compatibility, scalability. elaboration obtained 2-H-pyrimidine further demonstrated alkylation vinylation its C2 position.

Язык: Английский

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Catalytic efficiency of GO-PANI nanocomposite in the synthesis of N-Aryl-1,4-Dihydropyridine and hydroquinoline derivatives

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Янв. 22, 2025

Abstract In this research, graphene oxide-polyaniline (GO-PANI) nanocomposite was successfully synthesized and its catalytic performance evaluated for the synthesis of N-aryl-1,4-dihydropyridine (1,4-DHP) hydroquinoline derivatives. The GO nanosheets were prepared using Hummers’ method, in-situ polymerization aniline conducted with ammonium persulfate (APS) serving as initiator. demonstrated notable efficiency, achieving yields 80–94% 1,4-DHP derivatives 84–96% GO-PANI thoroughly characterized by various techniques, including Fourier Transforms Infrared spectroscopy (FT-IR), Field Emission Scanning Electron Microscopy (FE-SEM), X-ray Diffraction analysis (XRD), Thermogravimetric (TGA), Energy Dispersive (EDS), all which confirmed successful nanocomposite. Furthermore, after ten cycles reusability testing, retained high no significant degradation. This findings indicate that is a promising non-metal catalyst

Язык: Английский

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Difluorocarbene-Enabled Trifluoromethylation and Cyclization for the Synthesis of 3-(Trifluoromethyl)-4H-pyrans

Organic Letters, Год журнала: 2024, Номер unknown

Опубликована: Сен. 27, 2024

A three-component annulation reaction and trifluoromethylation for the construction of 3-(trifluoromethyl)-4

Язык: Английский

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Recent advances in the synthesis of nitrogen-containing heterocyclic compounds via multicomponent reaction and their emerging biological applications: a review

Journal of the Iranian Chemical Society, Год журнала: 2024, Номер unknown

Опубликована: Дек. 23, 2024

Язык: Английский

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Cu(ii)-catalyzed synthesis of N-sulfonated quinolin-2(1H)-one-3-carboxamides

Organic & Biomolecular Chemistry, Год журнала: 2024, Номер unknown

Опубликована: Янв. 1, 2024

Herein, we present an efficient Cu( ii )-catalyzed cascade synthesis of sulfonated 3-carboxamide quinolin-2-(1 H )-ones. Inthis paper, sulfonylhydrazides underwent unusual N–N bond cleavage and functioned as sulfamide synthons.

Язык: Английский

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