Base-controlled selective cleavage of the C–F bond of difluorocarbene for the divergent assembly of indolizines

Organic Chemistry Frontiers, Год журнала: 2024, Номер 11(15), С. 4214 - 4218

Опубликована: Янв. 1, 2024

A [3 + 1 1] cascade annulation reaction for the divergent construction of trisubstituted indolizines using sulfoxonium ylides, BrCF 2 CO Me and pyridinium salts as readily available substrates has been developed.

Язык: Английский

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Synthesis of β,β-Dithioketones by Merging C–C and C–S Bond Cleavage in [1 + 1 + 1 + 1 + 1 + 1] Annulation

Organic Letters, Год журнала: 2024, Номер 26(20), С. 4340 - 4345

Опубликована: Май 14, 2024

An unconventional [1 + 1 1] annulation process was developed for the construction of β,β-dithioketones by merging C–C and C–S bond cleavage. In this reaction, rongalite concurrently served as triple C1 units, dual sulfur(II) synthons, a reductant first time. Mechanism investigation indicated that reaction involved self-mediated valence state change rongalite. By performing step-economical method, challenging C5-substituted 1,3-dithiane can be achieved under mild simple conditions.

Язык: Английский

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Difluorocarbene-Enabled Trifluoromethylation and Cyclization for the Synthesis of 3-(Trifluoromethyl)-4H-pyrans

Organic Letters, Год журнала: 2024, Номер unknown

Опубликована: Сен. 27, 2024

A three-component annulation reaction and trifluoromethylation for the construction of 3-(trifluoromethyl)-4

Язык: Английский

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Intramolecular/Intermolecular Sequential Cyclization Accompanied by Double C–F Bond Cleavage: Access to Tricyclic Fluorine-Containing Pyrano[3,2-c]chromenes

The Journal of Organic Chemistry, Год журнала: 2024, Номер 89(22), С. 16553 - 16563

Опубликована: Окт. 28, 2024

Defluorinative cyclization of CF

Язык: Английский

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