Co(III) or Ru(II)-Catalyzed Selective C–H Alkynylation of 2-Pyridones and Their Derivatives with Bromoalkynes DOI

Quanjian Luo,

Han‐Chi Wang,

Jierui Zhou

et al.

The Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 5, 2024

We successfully reported selective C–H alkynylation of 2-pyridones with bromoalkynes under the catalysis Co(III) or Ru(II). The reaction used easily accessible instead high-valent iodine alkynes. There is a broad substrate scope good yields. In addition, 2-pyridone can be as weakly directing group for proximal aryl bond. This method offers an efficient approach synthesizing diverse derivatives, yielding alkynylated products up to 95% yield (>40 examples).

Language: Английский

Transient Directing Group-Assisted Palladium-Catalyzed C4-Alkynylation of Indoles DOI

Shuqi Guo,

Huanfeng Jiang,

Shaorong Yang

et al.

The Journal of Organic Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 10, 2025

Pd-catalyzed C4-selective alkynylation of indoles was established by employing glycine as a transient directing group. This reaction exhibits high regioselectivity with the tolerance wide scope functional groups to afford diverse alkynylated in moderate good yields. Moreover, readily accessible scale-up synthesis and further decorations achieve multifunctionalized demonstrate synthetic potential this protocol.

Language: Английский

Citations

0
Ru(II)-Catalyzed C–H Amination of 1,2,3-Benzotriazinones with Azide Compounds DOI

Han‐Chi Wang,

Quanjian Luo,

Jin‐Heng Li

et al.

The Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: 89(17), P. 12249 - 12254

Published: Aug. 8, 2024

A Ru(II)-catalyzed directed C–H amination of 1,2,3-benzotriazinones with azide compounds has been reported. The reaction a wide substrate scope organic azides good results and represents useful pathway to the construction versatile heterocyclic amino products. In addition, method can be used for phthalazinones, highlighting synthetic practicability strategy.

Language: Английский

Citations

2
Co(III) or Ru(II)-Catalyzed Selective C–H Alkynylation of 2-Pyridones and Their Derivatives with Bromoalkynes DOI

Quanjian Luo,

Han‐Chi Wang,

Jierui Zhou

et al.

The Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 5, 2024

We successfully reported selective C–H alkynylation of 2-pyridones with bromoalkynes under the catalysis Co(III) or Ru(II). The reaction used easily accessible instead high-valent iodine alkynes. There is a broad substrate scope good yields. In addition, 2-pyridone can be as weakly directing group for proximal aryl bond. This method offers an efficient approach synthesizing diverse derivatives, yielding alkynylated products up to 95% yield (>40 examples).

Language: Английский

Citations

0