Science of Advanced Materials,
Год журнала:
2023,
Номер
15(6), С. 725 - 747
Опубликована: Июнь 1, 2023
Green
chemistry
lowers
chemical
hazards
during
design,
manufacture,
and
use.
By
using
cleaner
solvents,
catalysts,
reaction
conditions,
this
technique
reduces
environmental
pollution
boosts
atom
economy
energy
efficiency.
Rapid
industrialization
urbanization
are
causing
significant
harm
to
our
environment
by
releasing
a
lot
of
dangerous
undesired
chemicals,
gases,
or
other
pollutants.
The
secrets
hidden
in
nature
its
by-products
must
now
be
discovered
us
order
enhance
the
synthesis
physiologically
moieties
foster
growth.
Heterocyclic
compounds
derivatives
exhibit
various
biological
potential
like
anticancer,
antimicrobial,
anticonvulsant,
analgesic,
antitubercular,
antiinflammatory
cardiovascular
activities.
This
make
them
good
candidates
for
future
medication
discovery
give
an
arsenal
treating
diseases.
article
provides
overview
numerous
environmentally
friendly
green
synthetic
techniques
used
create
diverse
heterocyclic
scaffolds
period
2002–2022.
It
is
anticipated
that
compilation
pertinent
information
will
significance
practical
value
chemists
specializing
organic
pharmaceutical
domains,
potentially
stimulating
additional
advancements
development
within
captivating
area
study.
Organometallics,
Год журнала:
2023,
Номер
42(19), С. 2692 - 2730
Опубликована: Сен. 21, 2023
N-heterocyclic
carbene
(NHC)
ligands
have
evolved
from
being
simple
lab
curiosities
to
tertiary
phosphine
mimics
finally
take
center
stage
as
unique
supporting
in
organometallic
chemistry,
homogeneous
catalysis,
and
more
recently
medicinal
chemistry
materials
science
applications.
Some
of
these
aspects
are
presented
here
a
perspective
researchers
that
been
fascinated
by
the
area
for
quite
some
time.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(16), С. 8651 - 8651
Опубликована: Авг. 8, 2024
This
review
highlights
significant
advancements
in
antibody–drug
conjugates
(ADCs)
equipped
with
metal-based
and
nature-inspired
payloads,
focusing
on
synthetic
strategies
for
antibody
conjugation.
Traditional
methods
such
us
maleimide
succinimide
conjugation
classical
condensation
reactions
are
prevalent
metallodrugs
natural
compounds.
However,
emerging
non-conventional
as
photoconjugation
gaining
traction
due
to
their
milder
conditions
and,
an
aspect
which
minimizes
side
reactions,
selective
formation
of
ADC.
The
also
summarizes
the
therapeutic
diagnostic
properties
these
ADCs,
highlighting
enhanced
selectivity
reduced
effects
cancer
treatment
compared
non-conjugated
payloads.
ADCs
combine
specificity
monoclonal
antibodies
cytotoxicity
chemotherapy
drugs,
offering
a
targeted
approach
elimination
cells
while
sparing
healthy
tissues.
mechanism
has
demonstrated
impressive
clinical
efficacy
various
malignancies.
Key
future
include
improved
linker
technology
stability
controlled
release
cytotoxic
agents,
incorporation
novel,
more
potent,
identification
new
cancer-specific
antigens
through
genomic
proteomic
technologies.
expected
play
crucial
role
combination
therapies
immune
checkpoint
inhibitors,
CAR-T
cells,
small
molecule
leading
durable
potentially
curative
outcomes.
Ongoing
research
trials
expanding
capabilities,
paving
way
effective,
safer,
personalized
treatments,
positioning
cornerstone
modern
medicine
hope
patients.
Chemistry - A European Journal,
Год журнала:
2023,
Номер
29(58)
Опубликована: Июль 18, 2023
The
prominent
role
of
gold-N-heterocyclic
carbene
(NHC)
complexes
in
numerous
research
areas
such
as
homogeneous
(photo)catalysis,
medicinal
chemistry
and
materials
science
has
prompted
organometallic
chemists
to
design
gold-based
synthons
that
permit
access
target
through
simple
synthetic
steps
under
mild
conditions.
In
this
review,
the
main
gold-NHC
employed
synthesis
are
discussed.
Mechanistic
aspects
involved
their
reactivity
well
applications
efficient
pre-catalysts,
antitumor
agents
and/or
photo-emissive
presented.
Frontiers in Bioengineering and Biotechnology,
Год журнала:
2023,
Номер
11
Опубликована: Апрель 18, 2023
High-grade
serous
ovarian
cancer
(HGSOC)
needs
new
technologies
for
improving
diagnosis
and
therapy.
It
is
a
fatal
disease
with
few
options
the
patients.
In
this
context,
dynamic
culture
systems
coupling
patient-derived
3D
microstructures
could
offer
opportunity
exploring
novel
therapeutic
approaches.
study,
we
optimized
passive
microfluidic
platform
organoids,
which
allows
standardized
approach
among
different
patients,
minimum
requirement
of
samples,
multiple
interrogations
biological
events,
rapid
response.
The
flow
was
to
improve
growth
avoiding
disruption
extracellular
matrix
(ECM).
Under
conditions
OrganoFlow
(tilting
angle
15°
an
interval
rocking
every
8
min),
organoids
grow
faster
than
when
they
are
in
static
number
dead
cells
reduced
over
time.
To
calculate
IC50
values
standard
chemotherapeutic
drugs
(carboplatin,
paclitaxel,
doxorubicin)
targeted
(ATRA),
approaches
were
utilized.
Resazurin
staining,
ATP-based
assay,
DAPI/PI
colocalization
assays
compared,
calculated.
results
showed
that
flow,
lower
conditions.
FITC-labeled
paclitaxel
shows
better
penetration
ECM
under
conditions,
start
die
after
48
h
instead
96
h,
respectively.
Cancer
last
frontiers
ex
vivo
testing
replicate
response
patients
clinic.
For
derived
from
ascites
or
tissues
Ovarian
have
been
used.
conclusion,
it
possible
develop
protocol
organoid
cultures
higher
rate,
drug
response,
into
ECM,
maintaining
samples'
vitals
collecting
data
on
same
plate
up
16
drugs.
Dalton Transactions,
Год журнала:
2023,
Номер
52(23), С. 7828 - 7835
Опубликована: Янв. 1, 2023
Full
characterisation
and
catalytic
potential
of
two
NHC–Ag(
i
)amide
complexes
with
the
influence
steric
bulk
NHC
calculated
via
percent
buried
volume
(%
V
Bur
),
Solid-G
(
G
M
)
AtomAccess
.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(17), С. 9337 - 9337
Опубликована: Авг. 28, 2024
The
search
for
new
antineoplastic
agents
is
imperative,
as
cancer
remains
one
of
the
most
preeminent
causes
death
worldwide.
Since
discovery
therapeutic
potential
cisplatin,
study
metallodrugs
in
chemotherapy
acquired
increasing
interest.
Starting
from
cisplatin
derivatives,
such
oxaliplatin
and
carboplatin,
last
years,
different
compounds
were
explored,
employing
metal
centers
iron,
ruthenium,
gold,
palladium.
Nonetheless,
face
several
drawbacks,
low
water
solubility,
rapid
clearance,
possible
side
toxicity.
Encapsulation
has
emerged
a
promising
strategy
to
overcome
these
issues,
providing
both
improved
biocompatibility
protection
payload
degradation
biological
environment.
In
this
respect,
liposomes,
which
are
spherical
vesicles
characterized
by
an
aqueous
core
surrounded
lipid
bilayers,
have
proven
be
ideal
candidates
due
their
versatility.
fact,
they
can
encapsulate
hydrophilic
hydrophobic
drugs,
biocompatible,
properties
tuned
improve
selective
delivery
tumour
sites
exploiting
passive
active
targeting.
review,
we
report
recent
findings
on
liposomal
formulations
metallodrugs,
with
focus
encapsulation
techniques
obtained
results.
Dalton Transactions,
Год журнала:
2024,
Номер
53(26), С. 11001 - 11008
Опубликована: Янв. 1, 2024
Carbene-metal-amide
(CMA)
complexes
of
gold,
silver,
and
copper
have
been
studied
extensively
for
their
photochemical/photocatalytic
properties
as
potential
(pre-)catalysts
in
organic
synthesis.
Herein,
the
design,
synthesis,
characterization
five
bench-stable
Au-,
Ag-,
Cu-NHC
bearing
benzotriazolyl
anion
an
amide
donor,
are
reported.
All
synthesized
a
facile
straightforward
manner,
using
mild
conditions.
The
catalytic
activity
Ag
Cu
was
propargylamide
cycloisomerization
carbonyl
hydrosilylation
reactions.
Both
CMA-catalyzed
transformations
proceed
under
conditions
highly
efficient
range
propargylamides
compounds,
respectively,
affording
desired
corresponding
products
good
to
excellent
yields.
Chemistry - A European Journal,
Год журнала:
2022,
Номер
28(47)
Опубликована: Июнь 2, 2022
A
straightforward
synthetic
protocol
leading
to
carbene-metal-amido
(CMA)
complexes
(metal=Au,
Cu)
using
a
mild
base
and
an
environmentally
desirable
solvent
(EtOH)
has
been
explored,
with
focus
on
bearing
backbone-substituted
N-heterocyclic
carbene
(NHC)
ligands,
including
BIAN-NHCs
(BIAN=bis(imino)acenaphthene).
The
novel
CMAs
were
structurally
characterized,
gold-based
diverse
NHCs
screened
as
simple,
Brønsted-basic
precatalysts.
readily
accessible
display
high
catalytic
activity
in
the
intermolecular
intramolecular
hydrocarboxylation
of
internal
alkynes
alkynoic
acids
respectively,
while
screening
reveals
ancillary
ligand
effect
these
systems.
