Pharmaceuticals,
Год журнала:
2024,
Номер
18(1), С. 9 - 9
Опубликована: Дек. 25, 2024
The
strict
connections/interactions
between
microbial
infections
and
cancer
are
nowadays
widely
accepted.
Hence,
the
dual
(or
multiple)
targeting
of
is
an
essential
issue
to
be
addressed.
In
this
context,
metal
complexes
have
gained
considerable
importance
effectiveness
in
medicinal
chemistry.
Particularly,
N-heterocyclic
carbene
(NHC)
with
transition
metals
emerged
as
very
promising
compounds.
Among
myriad
NHC–metal
complexes,
those
bearing
silver
will
subject
review.
Numerous
Ag(I)-NHC
revealed
high
antibacterial
and/or
anticancer
properties,
even
higher
than
reference
drugs.
Herein,
we
summarize
most
recent
studies
while
also
discussing
proposed
mechanism
action
offering
interesting
remark
about
research
field.
Literature
databases
(PubMed/MEDLINE,
Scopus,
Google
Scholar)
were
used
sources
search
literature,
referring
last
five
years.
Chemistry - A European Journal,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 5, 2025
New,
asymmetric
quinizarin-Au(I)-NHC
complexes
were
designed,
isolated,
and
fully
characterised
including
by
single
crystal
X-ray
crystallography.
Cytotoxicity
studies
showed
effective
growth
inhibition
in
HeLa
cervical
cancer
cells
with
IC
A
series
of
hetero-biscarbene
silver(I)
and
gold(I)
complexes
the
general
formula
[NHC-M-MIC]PF6
(NHC=imidazol-2-ylidene,
MIC=1,2,3-triazol-5-ylidene)
have
been
prepared
via
treatment
NHC-M-Cl
precursors
in
reaction
with
an
situ
generated
mesoionic
carbene
(MIC).
The
new
heteroleptic
fully
characterized
including
NMR
spectroscopy,
elemental
analysis,
melting
points
single
crystal
X-ray
diffraction.
derivatives
were
employed
successfully
solvent
free
KA2
(ketone-alkyne-amine)
coupling
for
preparation
a
quaternary
carbon-containing
propargyl
amines
while,
biscarbenes,
demonstrated
good
performance
A3
(aldehyde,
amine,
alkyne)
benzylic
oxidation
processes
under
low
catalyst
loadings.
The Journal of Organic Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 19, 2025
A
novel
[3+3]
cyclization
reaction
between
phenol
and
hydrazone
was
successfully
developed
under
electrochemically
driven
conditions.
This
provided
access
to
a
diverse
array
of
1,3,4-oxadiazinane
compounds
in
consistently
high
yields,
reaching
up
87%.
Notably,
the
exhibited
remarkable
tolerance
toward
broad
spectrum
both
substrates,
underscoring
its
versatility.
Moreover,
protocol
distinguished
itself
by
exceptional
atom
step
economy,
facilitating
efficient
construction
functionalized
1,3,4-oxadiazines.
The
synthetic
utility
this
approach
further
exemplified
scalability,
as
demonstrated
gram-scale
reactions,
substrate
scope.
Abstract
N
‐heterocyclic
carbenes
(NHCs)
are
a
class
of
compounds
known
for
their
biological
activities
which
the
presence
therapeutic
metal
can
enhance.
The
discovery
cisplatin
as
an
effective
anticancer
metallodrug
led
to
research
into
other
metal‐based
drugs,
not
only
but
applications
such
antimicrobial,
antirheumatic,
and
antidiabetic.
Since
metallic
silver
has
been
have
antimicrobial
efficacy,
Ag(I)‐NHC
complexes
developed
enhance
efficacy
both
NHC.
In
this
study,
we
present
current
review
activity
several
azolium
salts
corresponding
NHC
coinage
metals
(Ag,
Au,
Cu
in
order
importance).
We
fully
analyzed
discussed
efficacies
when
benchmarked
against
commercially
available
drugs.
Also
highlighted
where
studies
based
on
structure‐activity
relationships,
included
variations
wingtip
‐substituents
ligands
changes
type,
number
oxidation
state
ions
complex.
The Chemical Record,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 14, 2024
Abstract
This
review
provides
a
comprehensive
overview
of
research
on
1,2,4‐triazoles
conducted
over
the
last
fifteen
years.
1,2,4‐Triazoles
are
highly
significant
in
pharmaceutical
industry,
with
numerous
compounds
from
this
class
used
clinically
as
antifungal,
antiviral,
antibacterial,
anti‐inflammatory,
and
antitubercular
agents.
Beyond
their
relevance,
also
explores
role
material
science
agriculture.
In
science,
gaining
prominence,
particularly
development
energetic
materials
(EMs),
due
to
exceptional
properties
such
thermal
stability,
coordination
ability,
performance
comparable
well‐known
explosives.
Their
applications
extend
polymers,
corrosion
inhibitors,
metal‐organic
frameworks
(MOFs),
they
play
functional
for
sensors,
catalysis,
energy
storage.
Additionally,
addresses
general
aspects
synthetic
methodologies
functionalization
construction
1,2,4‐triazole
ring.
Synthetic
methods
discussed
include
metalation
synthesis,
cyclization
hydrazine
derivatives,
multicomponent
reactions,
amides
amidines,
microwave‐assisted
synthesis.
Given
significance
triazole
scaffold,
its
synthesis
has
garnered
considerable
attention
wide‐ranging
across
various
industrial
sectors.
Applied Organometallic Chemistry,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 29, 2024
ABSTRACT
The
current
study
involved
production,
comprehensive
structural
analysis,
and
physicochemical
characterizing
of
two
distinctive
complexes
namely,
Cu(
TBH
)
Zn(
);
donor
ligand:
N′‐(1‐(3,6‐dihydro‐4‐hydroxy‐2,6‐dioxo‐2H‐1,3‐thiazin‐5‐yl)ethylidene)‐2‐hydroxybenzohydrazide)
using
a
wide
range
analytical
methods,
including
elemental
UV–Vis,
FT‐IR,
1
HNMR
spectrometry,
molar
conductivity
magnetic
susceptibility
measurements,
thermal
analysis.
According
to
the
findings,
chelation
can
occur
through
O,
N,
O
atoms
monoanionic
chelator
for
generating
mono‐nuclear
chelates
with
tetrahedral
geometry
Cu
(II)
octahedral
Zn
(II).
anticarcinogenic
ability
its
coordinated
compounds
against
human
liver
cancer
(HepG‐2)
was
investigated.
complex
found
have
selective
promising
anticancer
activity
cell
line,
lower
IC
50
(liver
carcinoma
line)
higher
(normal
values
than
other
produced
standard
drugs.
Utilizing
DFT
computations,
molecular
structures
were
verified,
offering
detailed
understanding
their
quantum
chemical
characteristics.
A
quantitative
structure–activity
relationship
(QSAR)
model,
which
illustrates
association
between
DFT‐computed
descriptors
biological
activities
pIC
,
also
created
multiple
linear
regression
(MLR)
on
synthesized
as
medicines.
Additionally,
there
are
no
issues
compounds'
oral
bioavailability
according
(ROF)
Lipinski's
rule
five.
Furthermore,
docking
studies
CDK2
kinase
been
performed
validate
findings.
our
novel
nanodrug
exhibits
considerable
cytotoxic
activity,
prompting
further
into
pharmacological
profile
exploring
potential
in
drug
development.
Molecules,
Год журнала:
2024,
Номер
29(22), С. 5262 - 5262
Опубликована: Ноя. 7, 2024
-heterocyclic
carbene
(NHC)-gold
and
-silver
complexes
have
attracted
the
interest
of
scientific
community
because
their
multiple
applications
versatility
in
being
chemically
modified
order
to
improve
biological
properties.
However,
most
these
contain
one
or
more
chiral
centers,
been
obtained
studied
as
racemic
mixture.
In
particular,
concerning
interesting
medicinal
properties,
many
questions
about
how
chirality
may
influence
properties
still
remain
unanswered.
Aiming
at
a
better
understanding,
herein
series
enantiopure
NHC-gold
was
synthesized,
characterized
biologically
evaluated
different
vitro
systems.
The
individuated
exerted
based
on
complexed
metal
specific
configuration,
with
(
Organometallics,
Год журнала:
2024,
Номер
43(22), С. 2926 - 2934
Опубликована: Ноя. 8, 2024
In
recent
years,
NHC-derived
zwitterions
[NHC·CS(X)]
(X
=
S
and
NR)
have
gained
a
great
deal
of
attention
owing
to
their
various
applications
in
fields
such
as
organic
synthesis,
organometallics,
more
recently
catalysis.
this
work,
we
report
that
the
reaction
free
triarylated
triazol-5-ylidenes
(MIC)
with
equimolar
amounts
dithiocarboxylate
isothiocyanate
derivatives
allows
for
preparation
series
MIC·SC2
MIC·CSNAr
good
yields.
Their
potential
ligands
transition
metals
was
demonstrated
by
synthesis
ruthenium(II)
complexes
general
formulas
[RuCl(p-cymene)(MIC·CS2)]PF6
[RuCl(p-cymene)(MIC·CNSAr)]PF6.
The
ruthenium
were
fully
characterized
NMR
spectroscopy,
X-ray
crystallography,
TGA,
elemental
analysis.
new
successfully
applied
catalysts
transfer
hydrogenation
aldehydes
ketones
showing
efficiency
under
low
catalyst
loadings
providing
excellent
conversions.
Abstract
Ionic
liquids
(ILs),
based
on
1,3-dialkylimidazolium
cations,
are
frequently
used
solvent
components
or
auxiliaries
for
various
types
of
biomass
in
biorefinery
approaches.
Unless
washing
and
sample
preparation
have
been
carried
out
very
carefully,
analytical
samples
often
contain
residual
traces
such
ionic
liquids.
These
residues
can
compromise
the
quality
physicochemical
analyses,
as
was
demonstrated
monosaccharide
analysis
after
hydrolysis
by
gas
chromatography,
high-performance
thin-layer
ion
chromatography
(IC),
even
damage
equipment,
chromatographic
capillaries
IC
electrodes.
We
suggest
a
simple
procedure—short
stirring
with
solid
elemental
sulfur
adsorbed
alumina
scavenger—as
pretreatment
to
remove
interfering
imidazolium
IL
traces.
The
chemistry
underlying
this
is
conversion
cation
corresponding,
water-insoluble,
neutral,
volatile
1,3-dialkylimidazole-2-thiones.
Given
negative
effect
impurities,
minor
extension
one
short
additional
step
appears
be
small
price
pay
an
unperturbed
instrument-safe
analysis.
Graphical
abstract
