Directed discovery of high-loading nanoaggregates enabled by drug-matched oligo-peptide excipients
Chem,
Год журнала:
2025,
Номер
unknown, С. 102404 - 102404
Опубликована: Янв. 1, 2025
Язык: Английский
From small to large—The application of in situ polymerization within tumor cells
Aggregate,
Год журнала:
2024,
Номер
5(4)
Опубликована: Март 4, 2024
Abstract
The
“laboratory”
of
cells
has
the
capacity
to
polymerize
monosaccharides,
amino
acids,
and
nucleotides.
Tumor
cells,
characterized
by
overexpression
multiple
enzymes
existing
in
a
slightly
acidic
highly
redox‐potent
environment,
have
attracted
attention
chemists
aiming
transfer
chemical
reactions
from
traditional
laboratory
flask
this
“cellular
laboratory”.
Polymers,
resulting
repetitive
linkage
monomers,
garnered
extensive
utility
biomedical
field
due
their
diverse
structural
physicochemical
properties.
When
polymerization
reaction
proceeds
situ
within
tumor
transformation
small‐to‐large
combines
rapid
uptake
monomeric
molecules
with
strong
retention
ability
polymers,
exerting
profound
impact
on
drug
delivery
tumors.
Moreover,
it
shows
promising
applications
regulation
cell
behavior,
imaging,
therapy,
theranostics.
Given
functions
relation
review
focuses
comprehensive
examination
various
strategies
for
categorizing
these
based
formation
mechanisms
polymers.
domain
concerning
are
also
explored.
discussion
specific
limitations
current
research
insights
into
potential
future
directions
authors'
perspective
provided.
Язык: Английский
Cationic and amphiphilic peptide-based hydrogels with dual activities as anticancer and antibacterial agents
Soft Matter,
Год журнала:
2023,
Номер
20(6), С. 1236 - 1244
Опубликована: Дек. 26, 2023
The
emergence
of
peptide-based
functional
biomaterials
is
on
the
rise.
To
fulfil
this
purpose,
a
series
amphiphilic
peptides,
such
as
H
Язык: Английский
Peptide and protein-like hydrogels, synthesis, and applications in biomedicine
Elsevier eBooks,
Год журнала:
2025,
Номер
unknown, С. 113 - 134
Опубликована: Янв. 1, 2025
Язык: Английский
Corona-like Nanostructures: Quantum Dots Meet Pleural Fluid Proteins/Peptides for Theranostic Applications
Colloids and Surfaces B Biointerfaces,
Год журнала:
2025,
Номер
254, С. 114792 - 114792
Опубликована: Май 15, 2025
Язык: Английский
Iterative Design Reveals Molecular Domain Relationships in Supramolecular Peptide–Drug Conjugates
Biomacromolecules,
Год журнала:
2024,
Номер
25(7), С. 4482 - 4491
Опубликована: Июнь 13, 2024
Supramolecular
peptide-drug
conjugates
(sPDCs)
are
prepared
by
covalent
attachment
of
a
drug
moiety
to
peptide
motif
programmed
for
one-dimensional
self-assembly,
with
subsequent
physical
entanglement
these
fibrillar
structures
enabling
formation
nanofibrous
hydrogels.
This
class
prodrug
materials
presents
an
attractive
platform
mass-efficient
and
site-specific
delivery
therapeutic
agents
using
discrete,
single-component
molecular
design.
However,
continued
challenge
in
sPDC
development
is
elucidating
relationships
between
supramolecular
interactions
their
domains
the
resultant
impacts
on
assembly
outcomes
material
properties.
Inclusion
saturated
alkyl
segment
alongside
hydrophobic
domain
sPDCs
could
relieve
some
necessity
ordered,
prodrug-produg
interactions.
Accordingly,
nine
here
iterate
design
variables
amino
acid
sequence
prodrug-alkyl
block
All
molecules
spontaneously
formed
hydrogels
under
physiological
conditions,
indicating
less
hindered
thermodynamic
path
self-assembly
relative
previous
prodrug-only
designs.
studies
arrangement,
formation,
mechanical
properties
as
well
release
profiles
showed
complex
function
resulting
assemblies.
Together,
results
indicate
that
intrinsically
linked
holistic
coupled
contributions
from
directing
emergent
materials.
Язык: Английский
Assessment of the Enzymatic Dephosphorylation Kinetics in the Assemblies of a Phosphopentapeptide that Forms Intranuclear Nanoribbons
Biomacromolecules,
Год журнала:
2024,
Номер
25(2), С. 1310 - 1318
Опубликована: Янв. 24, 2024
Although
the
formation
of
peptide
assemblies
catalyzed
by
alkaline
phosphatase
(ALP)
has
received
increasing
attention
in
inhibiting
cancer
cells,
detailed
enzyme
kinetics
dephosphorylation
corresponding
phosphopeptide
have
yet
to
be
determined.
We
recently
discovered
that
from
a
phosphopentapeptide
can
form
intracellular
nanoribbons
kill
induced
pluripotent
stem
cells
or
osteosarcoma
but
enzymatic
remain
unknown.
Thus,
we
chose
examine
[NBD-LLLLpY
(1)]
concentrations
below
above
its
critical
micelle
concentration
(CMC).
Our
results
show
exhibits
CMC
75
μM
phosphate
saline
buffer,
and
apparent
Vmax
Km
values
are
approximately
0.24
μM/s
5.67
mM,
respectively.
Despite
remaining
incomplete
at
60
min
all
tested,
200
mainly
nanoribbons,
largely
produces
nanofibers,
generates
nanoparticles.
Moreover,
correlates
with
intranuclear
accumulation
pentapeptide.
By
providing
first
examination
assemblies,
this
work
further
supports
notion
phosphopentapeptides
act
as
new
functional
entity
for
controlling
cell
fates.
Язык: Английский
Gel-to-Solution Transition of Sulfhydryl Self-Assembled Peptide Hydrogels Undergoing Oxidative Modulation
ACS Applied Bio Materials,
Год журнала:
2023,
Номер
6(12), С. 5836 - 5841
Опубликована: Ноя. 29, 2023
The
design
of
self-assembling
biomaterials
needs
to
take
into
consideration
the
timing
and
location
self-assembly
process.
In
recent
decades,
principal
strategy
has
been
control
peptide
under
specific
conditions
enable
its
functional
performance.
However,
few
studies
have
explored
responsive
elimination
self-assembled
hydrogels
after
their
function
performed.
We
designed
ECAFF
(ECF-5),
which
reductive
can
self-assemble
a
hydrogel.
Upon
exposure
oxidizing
conditions,
disulfide
bonds
form
between
peptides,
altering
molecular
structure
impacting
capability.
As
result,
transition
soluble
state.
This
study
investigates
utilization
oxidation
induce
gel-to-solution
in
provides
an
explanation
for
degradation
following
free
radical
treatment.
Self-assembled
hydrogel
materials
be
from
fresh
perspective
by
considering
that
takes
place
execution.
Язык: Английский
Autocleaving Bonds for Better Drugs
ChemMedChem,
Год журнала:
2024,
Номер
19(13)
Опубликована: Март 30, 2024
Abstract
While
bond
formation
has
historically
been
the
mainstay
of
medicinal
chemistry,
phenomenon
cleavage
received
less
focus.
However,
success
numerous
oral
medications
demonstrates
importance
controlled
in
prodrugs
to
achieve
desired
therapeutic
outcomes.
Nevertheless,
effective
strategies
control
this
remain
limited.
This
concept
article
introduces
a
novel
approach:
employing
peptides
as
conjugates
drugs
modulate
hydrolysis
these
and
enhance
drug
efficacy.
The
begins
by
briefly
outlining
common
prodrug
strategies,
followed
few
representative
examples
how
can
be
leveraged
autohydrolysis
peptide‐conjugated
for
bacterial
cancer
cell
inhibition.
Finally,
it
provides
brief
outlook
on
future
potential
promising
new
research
direction
molecular
medicine.
Язык: Английский