Autocleaving Bonds for Better Drugs DOI Creative Commons
Jiaqi Guo,

Annabelle Chang,

Bing Xu

и другие.

ChemMedChem, Год журнала: 2024, Номер 19(13)

Опубликована: Март 30, 2024

Abstract While bond formation has historically been the mainstay of medicinal chemistry, phenomenon cleavage received less focus. However, success numerous oral medications demonstrates importance controlled in prodrugs to achieve desired therapeutic outcomes. Nevertheless, effective strategies control this remain limited. This concept article introduces a novel approach: employing peptides as conjugates drugs modulate hydrolysis these and enhance drug efficacy. The begins by briefly outlining common prodrug strategies, followed few representative examples how can be leveraged autohydrolysis peptide‐conjugated for bacterial cancer cell inhibition. Finally, it provides brief outlook on future potential promising new research direction molecular medicine.

Язык: Английский

Directed discovery of high-loading nanoaggregates enabled by drug-matched oligo-peptide excipients DOI
Naxhije Berisha,

Atena Farahpour,

Maithreyi Ramakrishnan

и другие.

Chem, Год журнала: 2025, Номер unknown, С. 102404 - 102404

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

1

From small to large—The application of in situ polymerization within tumor cells DOI Creative Commons

Ming-Jie Jia,

Yonghang Liu, Peng Wei

и другие.

Aggregate, Год журнала: 2024, Номер 5(4)

Опубликована: Март 4, 2024

Abstract The “laboratory” of cells has the capacity to polymerize monosaccharides, amino acids, and nucleotides. Tumor cells, characterized by overexpression multiple enzymes existing in a slightly acidic highly redox‐potent environment, have attracted attention chemists aiming transfer chemical reactions from traditional laboratory flask this “cellular laboratory”. Polymers, resulting repetitive linkage monomers, garnered extensive utility biomedical field due their diverse structural physicochemical properties. When polymerization reaction proceeds situ within tumor transformation small‐to‐large combines rapid uptake monomeric molecules with strong retention ability polymers, exerting profound impact on drug delivery tumors. Moreover, it shows promising applications regulation cell behavior, imaging, therapy, theranostics. Given functions relation review focuses comprehensive examination various strategies for categorizing these based formation mechanisms polymers. domain concerning are also explored. discussion specific limitations current research insights into potential future directions authors' perspective provided.

Язык: Английский

Процитировано

6

Cationic and amphiphilic peptide-based hydrogels with dual activities as anticancer and antibacterial agents DOI
Tanushree Mondal,

Akash Chatterjee,

Biswanath Hansda

и другие.

Soft Matter, Год журнала: 2023, Номер 20(6), С. 1236 - 1244

Опубликована: Дек. 26, 2023

The emergence of peptide-based functional biomaterials is on the rise. To fulfil this purpose, a series amphiphilic peptides, such as H

Язык: Английский

Процитировано

11

Peptide and protein-like hydrogels, synthesis, and applications in biomedicine DOI
Garry Laverty

Elsevier eBooks, Год журнала: 2025, Номер unknown, С. 113 - 134

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

0

Corona-like Nanostructures: Quantum Dots Meet Pleural Fluid Proteins/Peptides for Theranostic Applications DOI
Kerem Tok, Faezeh Ghorbanizamani, Hichem Moulahoum

и другие.

Colloids and Surfaces B Biointerfaces, Год журнала: 2025, Номер 254, С. 114792 - 114792

Опубликована: Май 15, 2025

Язык: Английский

Процитировано

0

Iterative Design Reveals Molecular Domain Relationships in Supramolecular Peptide–Drug Conjugates DOI

Matthew J. Sis,

Dongping Liu,

I. V. Allen

и другие.

Biomacromolecules, Год журнала: 2024, Номер 25(7), С. 4482 - 4491

Опубликована: Июнь 13, 2024

Supramolecular peptide-drug conjugates (sPDCs) are prepared by covalent attachment of a drug moiety to peptide motif programmed for one-dimensional self-assembly, with subsequent physical entanglement these fibrillar structures enabling formation nanofibrous hydrogels. This class prodrug materials presents an attractive platform mass-efficient and site-specific delivery therapeutic agents using discrete, single-component molecular design. However, continued challenge in sPDC development is elucidating relationships between supramolecular interactions their domains the resultant impacts on assembly outcomes material properties. Inclusion saturated alkyl segment alongside hydrophobic domain sPDCs could relieve some necessity ordered, prodrug-produg interactions. Accordingly, nine here iterate design variables amino acid sequence prodrug-alkyl block All molecules spontaneously formed hydrogels under physiological conditions, indicating less hindered thermodynamic path self-assembly relative previous prodrug-only designs. studies arrangement, formation, mechanical properties as well release profiles showed complex function resulting assemblies. Together, results indicate that intrinsically linked holistic coupled contributions from directing emergent materials.

Язык: Английский

Процитировано

2

Assessment of the Enzymatic Dephosphorylation Kinetics in the Assemblies of a Phosphopentapeptide that Forms Intranuclear Nanoribbons DOI
Yuchen Qiao,

Grace Wu,

Zhiyu Liu

и другие.

Biomacromolecules, Год журнала: 2024, Номер 25(2), С. 1310 - 1318

Опубликована: Янв. 24, 2024

Although the formation of peptide assemblies catalyzed by alkaline phosphatase (ALP) has received increasing attention in inhibiting cancer cells, detailed enzyme kinetics dephosphorylation corresponding phosphopeptide have yet to be determined. We recently discovered that from a phosphopentapeptide can form intracellular nanoribbons kill induced pluripotent stem cells or osteosarcoma but enzymatic remain unknown. Thus, we chose examine [NBD-LLLLpY (1)] concentrations below above its critical micelle concentration (CMC). Our results show exhibits CMC 75 μM phosphate saline buffer, and apparent Vmax Km values are approximately 0.24 μM/s 5.67 mM, respectively. Despite remaining incomplete at 60 min all tested, 200 mainly nanoribbons, largely produces nanofibers, generates nanoparticles. Moreover, correlates with intranuclear accumulation pentapeptide. By providing first examination assemblies, this work further supports notion phosphopentapeptides act as new functional entity for controlling cell fates.

Язык: Английский

Процитировано

1

Gel-to-Solution Transition of Sulfhydryl Self-Assembled Peptide Hydrogels Undergoing Oxidative Modulation DOI

Mai Hu,

Zhengli Liu, Zhiwei Shen

и другие.

ACS Applied Bio Materials, Год журнала: 2023, Номер 6(12), С. 5836 - 5841

Опубликована: Ноя. 29, 2023

The design of self-assembling biomaterials needs to take into consideration the timing and location self-assembly process. In recent decades, principal strategy has been control peptide under specific conditions enable its functional performance. However, few studies have explored responsive elimination self-assembled hydrogels after their function performed. We designed ECAFF (ECF-5), which reductive can self-assemble a hydrogel. Upon exposure oxidizing conditions, disulfide bonds form between peptides, altering molecular structure impacting capability. As result, transition soluble state. This study investigates utilization oxidation induce gel-to-solution in provides an explanation for degradation following free radical treatment. Self-assembled hydrogel materials be from fresh perspective by considering that takes place execution.

Язык: Английский

Процитировано

1

Autocleaving Bonds for Better Drugs DOI Creative Commons
Jiaqi Guo,

Annabelle Chang,

Bing Xu

и другие.

ChemMedChem, Год журнала: 2024, Номер 19(13)

Опубликована: Март 30, 2024

Abstract While bond formation has historically been the mainstay of medicinal chemistry, phenomenon cleavage received less focus. However, success numerous oral medications demonstrates importance controlled in prodrugs to achieve desired therapeutic outcomes. Nevertheless, effective strategies control this remain limited. This concept article introduces a novel approach: employing peptides as conjugates drugs modulate hydrolysis these and enhance drug efficacy. The begins by briefly outlining common prodrug strategies, followed few representative examples how can be leveraged autohydrolysis peptide‐conjugated for bacterial cancer cell inhibition. Finally, it provides brief outlook on future potential promising new research direction molecular medicine.

Язык: Английский

Процитировано

0