Autocleaving Bonds for Better Drugs DOI Creative Commons
Jiaqi Guo,

Annabelle Chang,

Bing Xu

et al.

ChemMedChem, Journal Year: 2024, Volume and Issue: 19(13)

Published: March 30, 2024

Abstract While bond formation has historically been the mainstay of medicinal chemistry, phenomenon cleavage received less focus. However, success numerous oral medications demonstrates importance controlled in prodrugs to achieve desired therapeutic outcomes. Nevertheless, effective strategies control this remain limited. This concept article introduces a novel approach: employing peptides as conjugates drugs modulate hydrolysis these and enhance drug efficacy. The begins by briefly outlining common prodrug strategies, followed few representative examples how can be leveraged autohydrolysis peptide‐conjugated for bacterial cancer cell inhibition. Finally, it provides brief outlook on future potential promising new research direction molecular medicine.

Language: Английский

From small to large—The application of in situ polymerization within tumor cells DOI Creative Commons

Ming-Jie Jia,

Yonghang Liu, Peng Wei

et al.

Aggregate, Journal Year: 2024, Volume and Issue: 5(4)

Published: March 4, 2024

Abstract The “laboratory” of cells has the capacity to polymerize monosaccharides, amino acids, and nucleotides. Tumor cells, characterized by overexpression multiple enzymes existing in a slightly acidic highly redox‐potent environment, have attracted attention chemists aiming transfer chemical reactions from traditional laboratory flask this “cellular laboratory”. Polymers, resulting repetitive linkage monomers, garnered extensive utility biomedical field due their diverse structural physicochemical properties. When polymerization reaction proceeds situ within tumor transformation small‐to‐large combines rapid uptake monomeric molecules with strong retention ability polymers, exerting profound impact on drug delivery tumors. Moreover, it shows promising applications regulation cell behavior, imaging, therapy, theranostics. Given functions relation review focuses comprehensive examination various strategies for categorizing these based formation mechanisms polymers. domain concerning are also explored. discussion specific limitations current research insights into potential future directions authors' perspective provided.

Language: Английский

Citations

5
Cationic and amphiphilic peptide-based hydrogels with dual activities as anticancer and antibacterial agents DOI
Tanushree Mondal,

Akash Chatterjee,

Biswanath Hansda

et al.

Soft Matter, Journal Year: 2023, Volume and Issue: 20(6), P. 1236 - 1244

Published: Dec. 26, 2023

The emergence of peptide-based functional biomaterials is on the rise. To fulfil this purpose, a series amphiphilic peptides, such as H

Language: Английский

Citations

11
Directed discovery of high-loading nanoaggregates enabled by drug-matched oligo-peptide excipients DOI
Naxhije Berisha,

Atena Farahpour,

Maithreyi Ramakrishnan

et al.

Chem, Journal Year: 2025, Volume and Issue: unknown, P. 102404 - 102404

Published: Jan. 1, 2025

Language: Английский

Citations

0
Peptide and protein-like hydrogels, synthesis, and applications in biomedicine DOI
Garry Laverty

Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 113 - 134

Published: Jan. 1, 2025

Language: Английский

Citations

0
Corona-like Nanostructures: Quantum Dots Meet Pleural Fluid Proteins/Peptides for Theranostic Applications DOI
Kerem Tok, Faezeh Ghorbanizamani, Hichem Moulahoum

et al.

Colloids and Surfaces B Biointerfaces, Journal Year: 2025, Volume and Issue: 254, P. 114792 - 114792

Published: May 15, 2025

Language: Английский

Citations

0
Iterative Design Reveals Molecular Domain Relationships in Supramolecular Peptide–Drug Conjugates DOI

Matthew J. Sis,

Dongping Liu,

I. V. Allen

et al.

Biomacromolecules, Journal Year: 2024, Volume and Issue: 25(7), P. 4482 - 4491

Published: June 13, 2024

Supramolecular peptide-drug conjugates (sPDCs) are prepared by covalent attachment of a drug moiety to peptide motif programmed for one-dimensional self-assembly, with subsequent physical entanglement these fibrillar structures enabling formation nanofibrous hydrogels. This class prodrug materials presents an attractive platform mass-efficient and site-specific delivery therapeutic agents using discrete, single-component molecular design. However, continued challenge in sPDC development is elucidating relationships between supramolecular interactions their domains the resultant impacts on assembly outcomes material properties. Inclusion saturated alkyl segment alongside hydrophobic domain sPDCs could relieve some necessity ordered, prodrug-produg interactions. Accordingly, nine here iterate design variables amino acid sequence prodrug-alkyl block All molecules spontaneously formed hydrogels under physiological conditions, indicating less hindered thermodynamic path self-assembly relative previous prodrug-only designs. studies arrangement, formation, mechanical properties as well release profiles showed complex function resulting assemblies. Together, results indicate that intrinsically linked holistic coupled contributions from directing emergent materials.

Language: Английский

Citations

2
Assessment of the Enzymatic Dephosphorylation Kinetics in the Assemblies of a Phosphopentapeptide that Forms Intranuclear Nanoribbons DOI
Yuchen Qiao,

Grace Wu,

Zhiyu Liu

et al.

Biomacromolecules, Journal Year: 2024, Volume and Issue: 25(2), P. 1310 - 1318

Published: Jan. 24, 2024

Although the formation of peptide assemblies catalyzed by alkaline phosphatase (ALP) has received increasing attention in inhibiting cancer cells, detailed enzyme kinetics dephosphorylation corresponding phosphopeptide have yet to be determined. We recently discovered that from a phosphopentapeptide can form intracellular nanoribbons kill induced pluripotent stem cells or osteosarcoma but enzymatic remain unknown. Thus, we chose examine [NBD-LLLLpY (1)] concentrations below above its critical micelle concentration (CMC). Our results show exhibits CMC 75 μM phosphate saline buffer, and apparent Vmax Km values are approximately 0.24 μM/s 5.67 mM, respectively. Despite remaining incomplete at 60 min all tested, 200 mainly nanoribbons, largely produces nanofibers, generates nanoparticles. Moreover, correlates with intranuclear accumulation pentapeptide. By providing first examination assemblies, this work further supports notion phosphopentapeptides act as new functional entity for controlling cell fates.

Language: Английский

Citations

1
Gel-to-Solution Transition of Sulfhydryl Self-Assembled Peptide Hydrogels Undergoing Oxidative Modulation DOI

Mai Hu,

Zhengli Liu, Zhiwei Shen

et al.

ACS Applied Bio Materials, Journal Year: 2023, Volume and Issue: 6(12), P. 5836 - 5841

Published: Nov. 29, 2023

The design of self-assembling biomaterials needs to take into consideration the timing and location self-assembly process. In recent decades, principal strategy has been control peptide under specific conditions enable its functional performance. However, few studies have explored responsive elimination self-assembled hydrogels after their function performed. We designed ECAFF (ECF-5), which reductive can self-assemble a hydrogel. Upon exposure oxidizing conditions, disulfide bonds form between peptides, altering molecular structure impacting capability. As result, transition soluble state. This study investigates utilization oxidation induce gel-to-solution in provides an explanation for degradation following free radical treatment. Self-assembled hydrogel materials be from fresh perspective by considering that takes place execution.

Language: Английский

Citations

1
Autocleaving Bonds for Better Drugs DOI Creative Commons
Jiaqi Guo,

Annabelle Chang,

Bing Xu

et al.

ChemMedChem, Journal Year: 2024, Volume and Issue: 19(13)

Published: March 30, 2024

Abstract While bond formation has historically been the mainstay of medicinal chemistry, phenomenon cleavage received less focus. However, success numerous oral medications demonstrates importance controlled in prodrugs to achieve desired therapeutic outcomes. Nevertheless, effective strategies control this remain limited. This concept article introduces a novel approach: employing peptides as conjugates drugs modulate hydrolysis these and enhance drug efficacy. The begins by briefly outlining common prodrug strategies, followed few representative examples how can be leveraged autohydrolysis peptide‐conjugated for bacterial cancer cell inhibition. Finally, it provides brief outlook on future potential promising new research direction molecular medicine.

Language: Английский

Citations

0