Chemistry - A European Journal,
Год журнала:
2024,
Номер
30(28)
Опубликована: Март 16, 2024
Abstract
The
cyclopropanation
reaction
of
alkenes
with
photolytically‐generated
chlorocarbenes
from
chlorodiazirines
is
reported
as
an
effective
way
to
prepare
substituted
3‐chloro‐3‐aryl‐cyclopropanes.
This
practical
and
efficient
approach
allows
the
synthesis
various
3‐chloro‐3‐aryl‐cyclopropanes
(32
examples)
in
continuous
flow
5‐minute
residence
time
under
light‐emitting
diode
(LED)
irradiation.
conditions
using
380
nm
LED
irradiation
were
successfully
extended
3‐bromo‐3‐aryl‐cyclopropanes
(3
examples).
Chemical Reviews,
Год журнала:
2023,
Номер
123(6), С. 3089 - 3126
Опубликована: Фев. 23, 2023
From
the
start
of
a
synthetic
chemist's
training,
experiments
are
conducted
based
on
recipes
from
textbooks
and
manuscripts
that
achieve
clean
reaction
outcomes,
allowing
scientist
to
develop
practical
skills
some
chemical
intuition.
This
procedure
is
often
kept
long
into
researcher's
career,
as
new
developed
similar
protocols,
intuition-guided
deviations
through
learning
failed
experiments.
However,
when
attempting
understand
systems
interest,
it
has
been
shown
model-based,
algorithm-based,
miniaturized
high-throughput
techniques
outperform
human
intuition
optimization
in
much
more
time-
material-efficient
manner;
this
covered
detail
paper.
As
many
chemists
not
exposed
these
undergraduate
teaching,
leads
disproportionate
number
scientists
wish
optimize
their
reactions
but
unable
use
methodologies
or
simply
unaware
existence.
review
highlights
basics,
cutting-edge,
modern
well
its
relation
process
scale-up
can
thereby
serve
reference
for
inspired
each
techniques,
detailing
several
respective
applications.
Chemical Science,
Год журнала:
2023,
Номер
14(16), С. 4230 - 4247
Опубликована: Янв. 1, 2023
This
review
explores
the
benefits
of
flow
chemistry
and
dispels
notion
that
it
is
a
mysterious
“black
box”,
demonstrating
how
can
push
boundaries
organic
synthesis
through
understanding
its
governing
principles.
Angewandte Chemie International Edition,
Год журнала:
2023,
Номер
62(36)
Опубликована: Июль 17, 2023
Abstract
Despite
their
abundance
in
organic
molecules,
considerable
limitations
still
exist
synthetic
methods
that
target
the
direct
C−H
functionalization
at
sp
3
‐hybridized
carbon
atoms.
This
is
even
more
case
for
light
alkanes,
which
bear
some
of
strongest
bonds
known
Nature,
requiring
extreme
activation
conditions
are
not
tolerant
to
most
molecules.
To
bypass
these
issues,
chemists
rely
on
prefunctionalized
alkyl
halides
or
organometallic
coupling
partners.
However,
new
regioselectively
a
variety
different
scaffolds
would
be
great
added
value,
only
late‐stage
biologically
active
molecules
but
also
catalytic
upgrading
cheap
and
abundant
hydrocarbon
feedstocks.
Here,
we
describe
general,
mild
scalable
protocol
enables
C(sp
)−H
carbonylation
saturated
hydrocarbons,
including
natural
products
using
photocatalytic
hydrogen
atom
transfer
(HAT)
gaseous
monoxide
(CO).
Flow
technology
was
deemed
crucial
enable
high
gas‐liquid
mass
rates
fast
reaction
kinetics,
needed
outpace
deleterious
pathways,
leverage
safe
process.
Organic Process Research & Development,
Год журнала:
2024,
Номер
28(8), С. 3307 - 3312
Опубликована: Июль 24, 2024
A
continuous
flow
approach
for
the
aerobic
photo-oxidation
of
benzylic
substrates
to
ketone
and
aldehyde
products
is
presented.
The
resulting
process
exploits
UV-A
LEDs
(375
nm)
in
combination
with
a
Corning
AFR
reactor
that
ensures
effective
gas-liquid
mixing
leads
short
residence
times
1
min.
variety
are
converted
their
corresponding
carbonyl
products,
scalability
demonstrated
produce
multigram
quantities
within
few
hours.
Overall,
this
offers
several
improvements
over
alternative
oxidation
methods
due
combined
use
air
as
an
oxidant
SAS
(sodium
anthraquinone-2
sulfonate)
water-soluble
photocatalyst.
greener
safer
conditions
together
intensification
principles
renders
attractive
further
industrial
applications.
Green Synthesis and Catalysis,
Год журнала:
2024,
Номер
5(4), С. 211 - 269
Опубликована: Май 6, 2024
The
development
of
catalytic
carbonylation
reactions
has
increased
considerably.
Although
many
reviews/chapters/books
on
have
been
published,
summaries
cheap
metal-catalyzed
aryl
halides
and
other
chemical
bonds
with
high
dissociation
energy
C-Y
(Y
=
O,
N,
H)
are
still
very
rare.
Focusing
green
sustainable
chemistry,
this
review
summarizes
discusses
the
achievements
carbonylative
transformations
(C(sp2)-X)
strong
based
non-expensive
metal
catalysts
(Co,
Mn,
Mo,
Ni,
Fe,
Cu),
photochemical
electrochemical
systems
developed
in
recent
decades.
Molecules,
Год журнала:
2024,
Номер
29(2), С. 398 - 398
Опубликована: Янв. 13, 2024
This
review
presents
a
comprehensive
evaluation
for
the
manufacture
of
organic
molecules
via
efficient
microfluidic
synthesis.
Microfluidic
systems
provide
considerably
higher
control
over
growth,
nucleation,
and
reaction
conditions
compared
with
traditional
large-scale
synthetic
methods.
synthesis
has
become
crucial
technique
quick,
affordable,
organometallic
compounds
complicated
characteristics
functions.
Therefore,
unique,
straightforward
flow
methodology
can
be
developed
to
conduct
syntheses
improve
their
efficiency.
Organic Process Research & Development,
Год журнала:
2024,
Номер
28(5), С. 1327 - 1354
Опубликована: Март 14, 2024
The
effective
handling
of
solids
in
a
continuous
flow
process
is
one
the
biggest
perceived
challenges
remaining
for
modern
chemistry.
This
Review
aims
to
consider
some
processes
chemistries
involving
which
have
been
successfully
implemented.
Learnings
from
design
these
systems,
and
identification
common
blockers,
will
guide
generalized,
strategic
approach
drive
efficiency
future
batch-to-flow
development
challenging,
heterogeneous
systems.
Assorted
techniques
managing
continuous-flow
synthesis
be
presented
herein
through
series
case
studies,
broken
down
into
several
key
categories;
solubility
considerations,
setup
components
modularity,
applications
ultrasonication,
reactor
type
Grignard
reactions.
iScience,
Год журнала:
2022,
Номер
25(3), С. 103892 - 103892
Опубликована: Фев. 10, 2022
Multi-step
organic
syntheses
of
various
drugs,
active
pharmaceutical
ingredients,
and
other
pharmaceutically
agriculturally
important
compounds
have
already
been
reported
using
flow
synthesis.
Compared
to
batch,
hazardous
reactive
reagents
can
be
handled
safely
in
flow.
This
review
discusses
the
pros
cons
chemistry
today's
scenario
recent
developments
devices.
The
majorly
emphasizes
on
synthesis
products
last
five
years
including
flibanserin,
imatinib,
buclizine,
cinnarizine,
cyclizine,
meclizine,
ribociclib,
celecoxib,
SC-560
mavacoxib,
efavirenz,
fluconazole,
melitracen
HCl,
rasagiline,
tamsulosin,
valsartan,
hydroxychloroquine.
Critical
steps
new
development
selected
are
also
discussed.
Advanced Intelligent Systems,
Год журнала:
2022,
Номер
5(4)
Опубликована: Дек. 23, 2022
The
urgency
of
finding
solutions
to
global
energy,
sustainability,
and
healthcare
challenges
has
motivated
rethinking
the
conventional
chemistry
material
science
workflows.
Self‐driving
labs,
emerged
through
integration
disruptive
physical
digital
technologies,
including
robotics,
additive
manufacturing,
reaction
miniaturization,
artificial
intelligence,
have
potential
accelerate
pace
materials
molecular
discovery
by
10–100X.
Using
autonomous
robotic
experimentation
workflows,
self‐driving
labs
enable
access
a
larger
part
chemical
universe
reduce
time‐to‐solution
an
iterative
hypothesis
formulation,
intelligent
experiment
selection,
automated
testing.
By
providing
data‐centric
abstraction
accelerated
cycle,
in
this
perspective
article,
required
hardware
software
technological
infrastructure
unlock
true
is
discussed.
In
particular,
process
intensification
as
accelerator
mechanism
for
modules
digitalization
strategies
further
cycle
sciences
are
