Journal of Flow Chemistry, Journal Year: 2024, Volume and Issue: 14(1), P. 257 - 279
Published: Feb. 23, 2024
Language: Английский
Chemical Reviews, Journal Year: 2023, Volume and Issue: 123(6), P. 3089 - 3126
Published: Feb. 23, 2023
From the start of a synthetic chemist's training, experiments are conducted based on recipes from textbooks and manuscripts that achieve clean reaction outcomes, allowing scientist to develop practical skills some chemical intuition. This procedure is often kept long into researcher's career, as new developed similar protocols, intuition-guided deviations through learning failed experiments. However, when attempting understand systems interest, it has been shown model-based, algorithm-based, miniaturized high-throughput techniques outperform human intuition optimization in much more time- material-efficient manner; this covered detail paper. As many chemists not exposed these undergraduate teaching, leads disproportionate number scientists wish optimize their reactions but unable use methodologies or simply unaware existence. review highlights basics, cutting-edge, modern well its relation process scale-up can thereby serve reference for inspired each techniques, detailing several respective applications.
Language: Английский
Citations
222
Chemical Science, Journal Year: 2023, Volume and Issue: 14(16), P. 4230 - 4247
Published: Jan. 1, 2023
This review explores the benefits of flow chemistry and dispels notion that it is a mysterious “black box”, demonstrating how can push boundaries organic synthesis through understanding its governing principles.
Language: Английский
Citations
199
Angewandte Chemie International Edition, Journal Year: 2023, Volume and Issue: 62(36)
Published: July 17, 2023
Abstract Despite their abundance in organic molecules, considerable limitations still exist synthetic methods that target the direct C−H functionalization at sp 3 ‐hybridized carbon atoms. This is even more case for light alkanes, which bear some of strongest bonds known Nature, requiring extreme activation conditions are not tolerant to most molecules. To bypass these issues, chemists rely on prefunctionalized alkyl halides or organometallic coupling partners. However, new regioselectively a variety different scaffolds would be great added value, only late‐stage biologically active molecules but also catalytic upgrading cheap and abundant hydrocarbon feedstocks. Here, we describe general, mild scalable protocol enables C(sp )−H carbonylation saturated hydrocarbons, including natural products using photocatalytic hydrogen atom transfer (HAT) gaseous monoxide (CO). Flow technology was deemed crucial enable high gas‐liquid mass rates fast reaction kinetics, needed outpace deleterious pathways, leverage safe process.
Language: Английский
Citations
32
Green Synthesis and Catalysis, Journal Year: 2024, Volume and Issue: 5(4), P. 211 - 269
Published: May 6, 2024
The development of catalytic carbonylation reactions has increased considerably. Although many reviews/chapters/books on have been published, summaries cheap metal-catalyzed aryl halides and other chemical bonds with high dissociation energy C-Y (Y = O, N, H) are still very rare. Focusing green sustainable chemistry, this review summarizes discusses the achievements carbonylative transformations (C(sp2)-X) strong based non-expensive metal catalysts (Co, Mn, Mo, Ni, Fe, Cu), photochemical electrochemical systems developed in recent decades.
Language: Английский
Citations
15
Organic Process Research & Development, Journal Year: 2024, Volume and Issue: 28(8), P. 3307 - 3312
Published: July 24, 2024
A continuous flow approach for the aerobic photo-oxidation of benzylic substrates to ketone and aldehyde products is presented. The resulting process exploits UV-A LEDs (375 nm) in combination with a Corning AFR reactor that ensures effective gas-liquid mixing leads short residence times 1 min. variety are converted their corresponding carbonyl products, scalability demonstrated produce multigram quantities within few hours. Overall, this offers several improvements over alternative oxidation methods due combined use air as an oxidant SAS (sodium anthraquinone-2 sulfonate) water-soluble photocatalyst. greener safer conditions together intensification principles renders attractive further industrial applications.
Language: Английский
Citations
15
Molecules, Journal Year: 2024, Volume and Issue: 29(2), P. 398 - 398
Published: Jan. 13, 2024
This review presents a comprehensive evaluation for the manufacture of organic molecules via efficient microfluidic synthesis. Microfluidic systems provide considerably higher control over growth, nucleation, and reaction conditions compared with traditional large-scale synthetic methods. synthesis has become crucial technique quick, affordable, organometallic compounds complicated characteristics functions. Therefore, unique, straightforward flow methodology can be developed to conduct syntheses improve their efficiency.
Language: Английский
Citations
13
Organic Process Research & Development, Journal Year: 2024, Volume and Issue: 28(5), P. 1327 - 1354
Published: March 14, 2024
The effective handling of solids in a continuous flow process is one the biggest perceived challenges remaining for modern chemistry. This Review aims to consider some processes chemistries involving which have been successfully implemented. Learnings from design these systems, and identification common blockers, will guide generalized, strategic approach drive efficiency future batch-to-flow development challenging, heterogeneous systems. Assorted techniques managing continuous-flow synthesis be presented herein through series case studies, broken down into several key categories; solubility considerations, setup components modularity, applications ultrasonication, reactor type Grignard reactions.
Language: Английский
Citations
13
Nature Chemistry, Journal Year: 2024, Volume and Issue: 16(4), P. 491 - 498
Published: March 28, 2024
Language: Английский
Citations
11
iScience, Journal Year: 2022, Volume and Issue: 25(3), P. 103892 - 103892
Published: Feb. 10, 2022
Multi-step organic syntheses of various drugs, active pharmaceutical ingredients, and other pharmaceutically agriculturally important compounds have already been reported using flow synthesis. Compared to batch, hazardous reactive reagents can be handled safely in flow. This review discusses the pros cons chemistry today's scenario recent developments devices. The majorly emphasizes on synthesis products last five years including flibanserin, imatinib, buclizine, cinnarizine, cyclizine, meclizine, ribociclib, celecoxib, SC-560 mavacoxib, efavirenz, fluconazole, melitracen HCl, rasagiline, tamsulosin, valsartan, hydroxychloroquine. Critical steps new development selected are also discussed.
Language: Английский
Citations
33
Advanced Intelligent Systems, Journal Year: 2022, Volume and Issue: 5(4)
Published: Dec. 23, 2022
The urgency of finding solutions to global energy, sustainability, and healthcare challenges has motivated rethinking the conventional chemistry material science workflows. Self‐driving labs, emerged through integration disruptive physical digital technologies, including robotics, additive manufacturing, reaction miniaturization, artificial intelligence, have potential accelerate pace materials molecular discovery by 10–100X. Using autonomous robotic experimentation workflows, self‐driving labs enable access a larger part chemical universe reduce time‐to‐solution an iterative hypothesis formulation, intelligent experiment selection, automated testing. By providing data‐centric abstraction accelerated cycle, in this perspective article, required hardware software technological infrastructure unlock true is discussed. In particular, process intensification as accelerator mechanism for modules digitalization strategies further cycle sciences are
Language: Английский
Citations
31