Journal of Gastrointestinal Cancer, Год журнала: 2025, Номер 56(1)
Опубликована: Фев. 24, 2025
Язык: Английский
Cell, Год журнала: 2023, Номер 186(8), С. 1729 - 1754
Опубликована: Апрель 1, 2023
Pancreatic ductal adenocarcinoma (PDAC) remains one of the deadliest cancers. Significant efforts have largely defined major genetic factors driving PDAC pathogenesis and progression. tumors are characterized by a complex microenvironment that orchestrates metabolic alterations supports milieu interactions among various cell types within this niche. In review, we highlight foundational studies driven our understanding these processes. We further discuss recent technological advances continue to expand complexity. posit clinical translation research endeavors will enhance currently dismal survival rate recalcitrant disease.
Язык: Английский
Процитировано
547
Cancer, Год журнала: 2022, Номер 128(24), С. 4251 - 4284
Опубликована: Окт. 27, 2022
Abstract Background The American Cancer Society, the Centers for Disease Control and Prevention, National Institute, North Association of Central Registries collaborate to provide annual updates on cancer occurrence trends in United States. Methods Data new diagnoses during 2001–2018 were obtained from Registries’ America Incidence file, which is comprised data Prevention‐funded Institute‐funded, population‐based registry programs. deaths 2001–2019 Center Health Statistics' Vital Statistics System. Five‐year average incidence death rates along with all cancers combined leading types are reported by sex, racial/ethnic group, age. Results Overall 497 per 100,000 among males (ranging 306 Asian/Pacific Islander 544 Black males) 431 females 309 473 Indian/Alaska Native females) 2014–2018. trend corresponding period was stable increased 0.2% year females, differing type. Among males, three (including pancreas kidney), seven prostate), decreased eight lung larynx) 18 most common considered this analysis. melanoma, liver, breast), four uterus), thyroid ovary) cancers. 2.3% 1.9% 2015–2019, sex‐specific declining reflected every major group. During 11 19 14 20 steepest declines (>4% year) melanoma. survival adenocarcinoma neuroendocrine pancreatic improved between 2001 2018; however, overall (2001–2018) mortality (2001–2019) continued increase site. children (younger than 15 years), recent mortality; among, adolescents young adults (aged 15–39 declined mortality. Conclusions decline overall, children, adults, treatment advances have led accelerated several sites, such as increases part reflect changes risk factors, screening test use, diagnostic practice. Racial/ethnic differences exist mortality, highlighting need understand address inequities. Population‐based inform prevention, early detection, efforts help reduce burden
Язык: Английский
Процитировано
358
Annals of Oncology, Год журнала: 2024, Номер 35(3), С. 308 - 316
Опубликована: Янв. 29, 2024
We predicted cancer mortality figures for 2024 the European Union (EU), its five most populous countries, and UK. focused on from colorectal (CRC).
Язык: Английский
Процитировано
47
CA A Cancer Journal for Clinicians, Год журнала: 2024, Номер 74(5), С. 405 - 432
Опубликована: Июль 11, 2024
In 2018, the authors reported estimates of number and proportion cancers attributable to potentially modifiable risk factors in 2014 United States. These data are useful for advocating informing cancer prevention control. Herein, based on up-to-date relative occurrence data, estimated invasive cases (excluding nonmelanoma skin cancers) deaths, overall 30 types among adults who were aged years older 2019 States, that factors. included cigarette smoking; second-hand smoke; excess body weight; alcohol consumption; consumption red processed meat; low fruits vegetables, dietary fiber, calcium; physical inactivity; ultraviolet radiation; seven carcinogenic infections. Numbers deaths obtained from sources with complete national coverage, factor prevalence nationally representative surveys, associated risks published large-scale pooled or meta-analyses. 2019, an 40.0% (713,340 1,781,649) all incident 44.0% (262,120 595,737) States evaluated Cigarette smoking was leading contributing (19.3% 28.5%, respectively), followed by weight (7.6% 7.3%, (5.4% 4.1%, respectively). For 19 types, more than one half considered this study. Lung had highest (201,660) (122,740) factors, female breast (83,840 cases), melanoma (82,710), colorectal (78,440) (25,800 deaths), liver (14,720), esophageal (13,600) deaths. Large numbers underscoring potential substantially reduce burden through broad equitable implementation preventive initiatives.
Язык: Английский
Процитировано
43
JNCI Journal of the National Cancer Institute, Год журнала: 2024, Номер 116(11), С. 1784 - 1790
Опубликована: Июль 13, 2024
Abstract Background With aging of the population and improvements in diagnosis, treatment, supportive care, number cancer survivors United States has increased; updated prevalence estimates are needed. Methods Cancer on January 1, 2022, was estimated using Prevalence Incidence Approach Model, utilizing incidence, survival, mortality. by age decade, sex, time from diagnosis calculated. The percentage projected US sex calculated as ratio sex-specific to population. Results There were an 18.1 million 2022. From 2022 2030, is increase 21.6 million; 2040, be 26 million. Long-term highly prevalent; 70% had lived 5 years or more after 11% 25 diagnosis. Among all females aged 40-54 years, 3.6% survivors; among 65-74 14.5% 85 older, 36.4% survivors. males 2.1% 16% those 48.3% Conclusions growing number. In States, most long-term very survivors, representing a substantial proportion
Язык: Английский
Процитировано
30
Scientific Reports, Год журнала: 2025, Номер 15(1)
Опубликована: Янв. 2, 2025
Cancers still globally endanger millions of people yearly; the incidences/mortalities colorectal cancers are particularly increasing. The natural nanoparticles (NPs) and marine biopolymers were anticipated to provide effectual safe significances for managing cancers. transformation curcumin nano-curcumin (NCur) was conducted with gum Arabic. resulted NCur utilized biosynthesis selenium NPs (SeNPs), then bioactive nanocomposites (NC) from them fucoidan (Fu) fabricated evaluated as candidates suppress (CaCo-2 HT-29) cells. NCur-synthesized SeNPs effectually produced mean diameters 34.67 ± 4.32 5.17 1.06 nm, respectively. plain NCs Fu/NCur/SeNPs characterization, infrared spectroscopy electron microscopy, emphasized their interaction conjugations. entire agents/NCs had potent cytotoxic effects against cancers' lines; NC most IC50 10.35 0.83 19.44 1.39 mg/L CaCo-2 HT-29 cells, respectively, which significantly exceeded action standard cisplatin drug. led vigorous DNA damages in cancerous proved comet assay. ultrastructure imagining (scanning/transmission microscopy) treated cells confirmed capability induce severe apoptosis deformation signs bio-based constituents advocate prospective applications preventing/managing adenocarcinoma.
Язык: Английский
Процитировано
4
Redox Biology, Год журнала: 2025, Номер unknown, С. 103515 - 103515
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
2
Cancer, Год журнала: 2022, Номер 129(1), С. 8 - 8
Опубликована: Дек. 12, 2022
This news section offers Cancer readers timely information on events, public policy analysis, topical issues, and personalities. In this issue, we present findings from part one of the Annual Report to Nation Status Cancer, which provides statistics incidence mortality rates across cancer types demographics. addition, a new study shows that combining metastasis‐directed radiation therapy with intermittent hormone improves progression‐free survival for advanced prostate updated American Society Clinical Oncology guidelines HER2‐positive breast provide recommendations based systematic evaluation best evidence date by panel experts.
Язык: Английский
Процитировано
46
JNCI Cancer Spectrum, Год журнала: 2023, Номер 7(1)
Опубликована: Янв. 3, 2023
Abstract Endometrial cancer (EC) incidence is on the rise. Although early-onset endometrial (EOEC; age at diagnosis <50 years) relatively uncommon, of EOEC has been reportedly increasing in recent decades. However, rising not thoroughly described with regard to racial and ethnic disparities compared late-onset EC (age ≥50 years). We used Cancer North America (CiNA) Analytic File, 1995-2018, from American Association Central Registries, which allowed us examine trends invasive by groups diagnosis. found striking differences for demographic tumor characteristics as well patterns time between EC. The faster increases rates, especially among non-White women, mirror similar observations other cancers, pointing a possible link obesity epidemic younger generations.
Язык: Английский
Процитировано
40
Nature Communications, Год журнала: 2023, Номер 14(1)
Опубликована: Июль 18, 2023
Abstract A comprehensive characterization of blood proteome profiles in cancer patients can contribute to a better understanding the disease etiology, resulting earlier diagnosis, risk stratification and monitoring different subtypes. Here, we describe use next generation protein profiling explore signature across representing many major types. Plasma 1463 proteins from more than 1400 are measured minute amounts collected at time diagnosis before treatment. An open access Disease Blood Atlas resource allows exploration individual patients. We also present studies which classification models based on machine learning have been used for identification set associated with each analyzed cancers. The implication precision medicine plasma is discussed.
Язык: Английский
Процитировано
34