Nature Communications,
Год журнала:
2024,
Номер
15(1)
Опубликована: Апрель 30, 2024
Abstract
Puberty
is
a
crucial
phase
for
the
development
of
female
sexual
behavior.
Growing
evidence
suggests
that
stress
during
this
period
may
interfere
with
However,
neural
circuits
involved
in
alteration
remain
elusive.
Here,
we
demonstrated
mice
pubertal
permanently
disrupted
performance
without
affecting
preference.
This
was
associated
reduced
expression
and
activation
neuronal
nitric
oxide
synthase
(nNOS)
ventrolateral
part
ventromedial
hypothalamus
(VMHvl).
Fiber
photometry
revealed
VMHvl
nNOS
neurons
are
strongly
responsive
to
male
olfactory
cues
being
substantially
pubertally
stressed
females.
Finally,
treatment
NO
donor
partially
restored
study
provides
insights
into
involvement
processing
important
In
addition,
exposure
puberty
disrupts
integration
leading
Endocrine Reviews,
Год журнала:
2018,
Номер
39(3), С. 333 - 368
Опубликована: Янв. 17, 2018
The
fertility
and
survival
of
an
individual
rely
on
the
ability
periphery
to
promptly,
effectively,
reproducibly
communicate
with
brain
neural
networks
that
control
reproduction,
food
intake,
energy
homeostasis.
Tanycytes,
a
specialized
glial
cell
type
lining
wall
third
ventricle
in
median
eminence
hypothalamus,
appear
act
as
linchpin
these
processes
by
dynamically
controlling
secretion
neuropeptides
into
portal
vasculature
hypothalamic
neurons
regulating
blood-brain
blood–cerebrospinal
fluid
exchanges,
both
depend
cells
adapt
their
morphology
physiological
state
individual.
In
addition
barrier
properties,
tanycytes
possess
sense
blood
glucose
levels,
play
fundamental
active
role
shuttling
circulating
metabolic
signals
intake.
Moreover,
accumulating
data
suggest
that,
keeping
putative
descent
from
radial
cells,
are
endowed
stem
properties
may
respond
dietary
or
reproductive
cues
modulating
neurogenesis.
Tanycytes
could
thus
constitute
missing
link
loop
connecting
behavior,
hormonal
changes,
signal
transduction,
central
neuronal
activation
and,
finally,
behavior
again.
this
article,
we
will
examine
recent
advances
understanding
tanycytic
plasticity
function
hypothalamus
underlying
molecular
mechanisms.
We
also
discuss
involvement
therapeutic
potential
disorders.
Nature Communications,
Год журнала:
2018,
Номер
9(1)
Опубликована: Янв. 22, 2018
Sexual
behavior
is
essential
for
the
survival
of
many
species.
In
female
rodents,
mate
preference
and
copulatory
depend
on
pheromones
are
synchronized
with
ovulation
to
ensure
reproductive
success.
The
neural
circuits
driving
this
orchestration
in
brain
have,
however,
remained
elusive.
Here,
we
demonstrate
that
neurons
controlling
mammalian
at
core
a
branching
circuit
governing
both
behavior.
We
show
male
odors
detected
vomeronasal
organ
activate
kisspeptin
mice.
Classical
kisspeptin/Kiss1R
signaling
subsequently
triggers
olfactory-driven
preference.
contrast,
elicited
by
parallel
independent
Kiss1R
involving
nitric
oxide
signaling.
Consistent
this,
find
impinge
onto
oxide-synthesizing
ventromedial
hypothalamus.
Our
data
establish
as
central
regulatory
hub
orchestrating
sexual
mouse
brain.
British Journal of Pharmacology,
Год журнала:
2019,
Номер
177(24), С. 5437 - 5458
Опубликована: Июль 26, 2019
Nitric
oxide
(NO)
is
a
versatile
molecule
that
plays
key
roles
in
the
development
and
survival
of
mammalian
species
by
endowing
brain
neuronal
networks
with
ability
to
make
continual
adjustments
function
response
moment‐to‐moment
changes
physiological
input.
Here,
we
summarize
progress
field
argue
NO‐synthetizing
neurons
NO
signalling
provide
core
hub
for
integrating
sensory‐
homeostatic‐related
cues,
control
bodily
functions,
potential
target
new
therapeutic
opportunities
against
several
neuroendocrine
behavioural
abnormalities.
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2020,
Номер
unknown
Опубликована: Июнь 9, 2020
Abstract
Most
patients
with
COVID-19,
caused
by
severe
acute
respiratory
syndrome
coronavirus
2
(SARS-CoV-2),
display
neurological
symptoms,
and
failure
in
certain
cases
could
be
of
extra-pulmonary
origin.
Hypothalamic
neural
circuits
play
key
roles
sex
differences,
diabetes,
hypertension,
obesity
aging,
all
risk
factors
for
besides
being
connected
to
olfactory/gustative
brainstem
cardiorespiratory
centers.
Here,
human
brain
gene-expression
analyses
immunohistochemistry
reveal
that
the
hypothalamus
associated
regions
express
angiotensin-converting
enzyme
transmembrane
proteinase,
serine
2,
which
mediate
SARS-CoV-2
cellular
entry,
correlation
genes
or
pathways
involved
physiological
functions
viral
pathogenesis.
A
post-mortem
patient
shows
invasion
replication
both
olfactory
bulb
hypothalamus,
while
animal
studies
indicate
hormones
metabolic
diseases
influence
this
susceptibility.
PLoS ONE,
Год журнала:
2019,
Номер
14(3), С. e0213927 - e0213927
Опубликована: Март 27, 2019
The
normal
function
of
the
mammalian
reproductive
axis
is
strongly
influenced
by
physiological,
metabolic
and
environmental
factors.
Kisspeptin
neuropeptides,
encoded
Kiss1
gene,
are
potent
regulators
stimulating
gonadodropin
releasing
hormone
secretion
from
hypothalamus.
To
understand
how
modulated
higher
order
neuronal
inputs
we
have
mapped
afferent
circuits
into
arcuate
(ARC)
neurons.
We
used
a
transgenic
mouse
that
expresses
CRE
recombinase
in
neurons
for
conditional
viral
tracing
with
genetically
modified
viruses.
CRE-mediated
activation
these
viruses
allows
virus
to
move
transynaptically
label
primary
or
secondary
Several
regions
brain
showed
synaptic
connectivity
including
proopiomelanocortin
ARC
itself,
kisspeptin
anteroventral
periventricular
nucleus,
vasopressin
supraoptic
suprachiasmatic
nuclei,
thyrotropin
paraventricular
nucleus
unidentified
other
subfornical
organ,
amygdala,
interpeduncular
ventral
premammilary
basal
stria
terminalis
visual,
somatosensory
piriform
cortex.
These
data
provide
an
insight
activity
may
be
regulated
signals
detailed
neuroanatomical
map
future
functional
studies.
Abstract
The
ventromedial
nucleus
of
the
hypothalamus
(VMH)
is
a
complex
brain
structure
that
integral
to
many
neuroendocrine
functions,
including
glucose
regulation,
thermogenesis,
and
appetitive,
social,
sexual
behaviors.
As
such,
it
little
surprise
under
intensive
investigation
decipher
mechanisms
which
underlie
these
diverse
roles.
Developments
in
genetic
investigative
tools,
for
example
targeting
steroidogenic
factor-1-expressing
neurons,
have
allowed
us
take
closer
look
at
VMH,
its
connections,
how
affects
competing
In
current
review,
we
aim
integrate
recent
findings
into
literature
contemplate
conclusions
can
be
drawn.
Cell Reports,
Год журнала:
2022,
Номер
39(12), С. 110978 - 110978
Опубликована: Июнь 1, 2022
The
cerebrovasculature
and
its
mural
cells
must
meet
brain
regional
energy
demands,
but
how
their
spatial
relationship
with
different
neuronal
cell
types
varies
across
the
remains
largely
unknown.
Here
we
apply
brain-wide
mapping
methods
to
comprehensively
define
quantitative
relationships
between
cerebrovasculature,
capillary
pericytes,
glutamatergic
GABAergic
neurons,
including
nitric
oxide
synthase-positive
(nNOS+)
neurons
subtypes
in
adult
mice.
Our
results
show
high
densities
of
vasculature
fluid
conductance
pericytes
primary
motor
sensory
cortices
compared
association
that
significant
positive
negative
correlations
energy-demanding
parvalbumin+
vasomotor
nNOS+
respectively.
Thalamo-striatal
areas
are
connected
also
suggesting
dense
support
for
processing
areas.
cellular-resolution
resource
offers
opportunities
examine
cerebrovascular
network
composition
understudied
subcortical
