Global, regional and national burden, incidence, and mortality of cervical cancer

Cancer Reports, Год журнала: 2022, Номер 6(3)

Опубликована: Дек. 21, 2022

Abstract Aim Among gynecological cancers, cervical cancer is the most common cause of cancer‐related death in developing countries. This study analyzes incidence, mortality, and burden using Global Burden Disease (GBD) 2019 study. Materials Methods The GBD (2019) data on was extracted from Health Data Exchange (GHDx) query tool. Age‐standardized rate (ASR) deaths, lost years life (YLLs), with disabilities (YLDs), adjusted (DALYs) women were extracted. globally for 204 countries groups based a socio‐demographic index (SDI), World Organization (WHO) regions, continents, Bank 22 regions. Results higher standardized age incidence lower SDI countries, Africa, African region (According to WHO), Sub‐Saharan Africa regions). highest deaths ASR low SDI, low‐income group, Organization), According classification, DALYs Low‐income then American region, Latin America & Caribbean‐WB (Based Conclusion In 2019, mostly affected socioeconomic status. Given that highly preventable, access screening services presence trained knowledgeable health care staff can reduce illness, suffering, caused by this malignancy. It recommended use national international potentials

Язык: Английский

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Post Treatment Sexual Function and Quality of Life of Patients Affected by Cervical Cancer: A Systematic Review

Medicina, Год журнала: 2023, Номер 59(4), С. 704 - 704

Опубликована: Апрель 4, 2023

Introduction: The aim of this study is to analyze the available scientific evidence regarding quality life (QoL) and sexual function (SF) in patients affected by cervical cancer (CC) after surgical adjuvant treatments. Materials Methods: Preliminary research was conducted via electronic database (MEDLINE, PubMed Cochrane Library) with use a combination following keywords: SF, QoL, CC. principal findings considered present review were design, number included each study, information about malignancy (histology stage disease), questionnaires administered, concerning SF QoL. Results: All studies published between 2003-2022. selected consisted one randomized control seven observational (three prospective series), nine case studies. scores used focused on QOL, fatigue, psychological aspects. reported decreased QOL. most developed European Organization for Research Treatment Cancer Quality Life Questionnaire (EORTC QLQ-C30), Female Sexual Function Index (FSFI), Hospital Anxiety Depression scale (HADS), Distress Scale (FSDS). Discussion: In addition perception body image, several factors coexist influencing outcomes such as physical, hormonal, psychological. Conclusions: dysfunction CC treatment has multifactorial aetiology which negatively affects life. For these reasons, it important follow support multidisciplinary team (doctors, nurses, psychologists, dieticians) before therapy. This type tailored therapeutic approach should become standard. Women be informed possible vaginal changes menopausal symptoms surgery positive effects

Язык: Английский

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The global incidence, mortality, and burden of uterine cancer in 2019 and correlation with SDI, tobacco, dietary risks, and metabolic risk factors: An ecological study

Health Science Reports, Год журнала: 2024, Номер 7(1)

Опубликована: Янв. 1, 2024

Abstract Background and Aim Endometrial cancer (EC) is the sixth most common among women worldwide. Since global studies are based on awareness of incidence trend, mortality, geographical diversity, level social development income countries, this study was conducted to investigate trend uterine (UC) in world 2019. Methods Age‐standardized rates (ASR) incidence, deaths, prevalence, disability‐adjusted life years (DALYs) UC, as well targeted risk factors, were extracted from Global Burden Disease (GBD) online database Pearson correlation coefficient SPSS 16 used calculate between factors ASR epidemiological indicators. Statistical significance considered p < 0.05. Results In 2019, age‐specific death rate UC peaking at 60–64 65–69 years, respectively. The highest age‐standardized per 100,000 people for has been reported Northern Mariana Islands, high sociodemographic index (SDI) World Bank High‐Income category, Europe continent Health Organization (WHO) regions found European Region. Grenada, SDI continent, WHO DALYs 53.54 inhabitants, which 48.49 cases related lost (YLLs) 5.05 lived with disability. Conclusion According GBD‐2019, DALY Europe. evidence traces diversity can be seen inequalities UC. Race, ethnicity, economic status, education awareness, co‐morbidities, access, grade, histological type tumor important causes inequality.

Язык: Английский

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Approach to radical hysterectomy for cervical cancer after the LACC trial and associated complications: a NSQIP study

American Journal of Obstetrics and Gynecology, Год журнала: 2024, Номер unknown

Опубликована: Авг. 1, 2024

Язык: Английский

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Religious beliefs and practices toward HPV vaccine acceptance in Islamic countries: A scoping review

PLoS ONE, Год журнала: 2024, Номер 19(8), С. e0309597 - e0309597

Опубликована: Авг. 29, 2024

Background Despite the availability of effective HPV vaccines, their acceptance in Islamic countries is often influenced by religious beliefs, practices, and misconceptions. Objective This review aimed to identify current literature on beliefs any misconceptions toward vaccine within Organisation Cooperation (OIC) countries. Method Using key terms, a systematic search MEDLINE/PubMed, Embase, CINAHL yielded 23 studies that met inclusion exclusion criteria. The scope this included all research articles published English until October 31, 2023. A form based aim study was developed used extract data. Results highlights complexity relationship between uptake. findings reveal significant objections among number Muslims. Some them believe vaccines lead infertility sexual promiscuity, defy norms, are sneaky way inject good Muslims with haram ingredients, an abandonment righteous principles general. Conclusions Vaccine hesitancy result doubts regarding vaccine’s safety, necessity, compatibility beliefs. It recommended encourage uptake using public health strategies adopt holistic approach incorporates religious, cultural, social aspects.

Язык: Английский

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CDCA genes as prognostic and therapeutic targets in Colon adenocarcinoma

Hereditas, Год журнала: 2025, Номер 162(1)

Опубликована: Фев. 10, 2025

Abstract Objectives The study investigates the role of Cell Division Cycle Associated (CDCA) genes in colorectal cancer (COAD) by analyzing their differential expression, epigenetic alterations, prognostic significance, and functional associations. Methodology This employed a detailed silico vitro experiments-based methodology. Results RT-qPCR assays reveal significantly elevated mRNA levels CDCA2, CDCA3, CDCA4, CDCA5, CDCA7, CDCA8 COAD cell lines compared to controls. Bisulfite sequencing indicates reduced promoter methylation CDCA gene promoters lines, suggesting an regulatory mechanism. Analysis large TCGA datasets confirms increased expression tissues. Survival analysis using cSurvival database demonstrates negative correlations between patient overall survival. Additionally, Lasso regression-based models predict survival outcomes patients. Investigating immune modulation, inversely correlates with infiltration modulators. miRNA-mRNA network identifies miRNAs targeting genes, validated showing up-regulation has-mir-10a-5p has-mir-20a-5p Drug sensitivity suggests resistance specific drugs patients expression. Furthermore, crucial states COAD, including “angiogenesis, apoptosis, differentiation, hypoxia, inflammation, metastasis.” Additional experiments revealed that CDCA2 CDCA3 knockdown SW480 SW629 cells proliferation colony formation while enhancing migration. Conclusion Overall, elucidates multifaceted progression, providing insights into potential diagnostic, prognostic, therapeutic implications.

Язык: Английский

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Temporal trends of tracheal, bronchus, and lung cancer between 2010 and 2019, in Asian countries by geographical region and sociodemographic index, comparison with global data

Thoracic Cancer, Год журнала: 2023, Номер 14(18), С. 1668 - 1706

Опубликована: Май 1, 2023

This study aimed to describe the trends in incidence, mortality, and burden of tracheal, bronchial lung (TBL) cancer Asia from 2010 through 2019 compare with global other continental data.We collected TBL data Global Burden Disease (GBD) 49 countries territories Asia. For all locations, annual case age-standardized rates (ASRs) were used investigate prevalence, disability-adjusted life-years (DALYs) 2019. The relative difference (%) between years was show comparative variations ASRs for indicators studied.In 2019, more than 55% cases deaths occurred Asian countries. A total 57% patients lived almost 60% imposed on From incidences, deaths, prevalence cases, DALYs number increased over 1.34-, 1.31-, 1.26-fold, During this period, incidence rate (ASIR), death (ASDR), (ASPR), (DALYs ASR) decreased by 1, 3, 4, 4%, respectively. While at same time, decreasing trend these globally America Europe happened faster. In age-specific death, DALY peaking 65-74, 70-74, 65-69, 65-69 years, highest ASIR, ASDR, ASR observed East ASPR high-income Pacific Central experienced a ASIR South increasing only Asia, among high sociodemographic index (SDI) countries, Brunei Darussalam had Republic Korea ASPR. Among high-middle SDIs, Turkey Georgia; middle China Armenia; low-middle Mongolia Democratic People's ASPR, cancer. low SDI Pakistan cancer.Most occurs is slower regions. Therefore, implementation necessary measures order reduce process considered urgent.

Язык: Английский

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Gold nanoparticles (AuNPs) decrease the viability of cervical cancer cells by inducing the BAX gene and activating antioxidant enzymes

Molecular Biology Reports, Год журнала: 2024, Номер 51(1)

Опубликована: Фев. 8, 2024

Язык: Английский

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Enhancing Cervical Cancer Screening: Review of p16/Ki-67 Dual Staining as a Promising Triage Strategy

Diagnostics, Год журнала: 2024, Номер 14(4), С. 451 - 451

Опубликована: Фев. 19, 2024

Cervical cancer, primarily caused by high-risk human papillomavirus (HR-HPV) types 16 and 18, is a major global health concern. Persistent HR-HPV infection can progress from reversible precancerous lesions to invasive cervical which driven the oncogenic activity of (HPV) genes, particularly E6 E7. Traditional screening methods, including cytology HPV testing, have limited sensitivity specificity. This review explores application p16/Ki-67 dual-staining for cancer screening. advanced immunocytochemical method allows simultaneously detecting p16 Ki-67 proteins within epithelial cells, offering more specific approach triaging HPV-positive women. Dual staining traditional methods are compared, demonstrating their high negative predictive value but low The increased dual results in higher detection rates CIN2+ lesions, crucial preventing progression. However, its specificity may lead false-positive unnecessary biopsies. implications integrating into contemporary strategies, considering evolving landscape vaccination changes genotype prevalence, also discussed. New guidelines further research necessary elucidate long-term effects protocols.

Язык: Английский

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Global incidence, mortality, and burden of esophageal cancer, and its correlation with SDI, metabolic risks, fasting plasma glucose, LDL cholesterol, and body mass index: An ecological study

Health Science Reports, Год журнала: 2023, Номер 6(6)

Опубликована: Июнь 1, 2023

Esophageal cancer (EC) is one of the most common gastrointestinal malignancies. The geographical variation shows influence genetic factors, ethnicity, and distribution various risk factors. Accurate knowledge EC epidemiology at global level will help to develop management strategies. Therefore, present study was conducted investigate regional disease burden EC, including incidence, mortality, this in 2019.

Язык: Английский

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