Heliyon, Journal Year: 2024, Volume and Issue: 10(10), P. e31596 - e31596
Published: May 1, 2024
According to estimates, there were 570,000 new cases of cervical cancer in 2018, making it the fourth most common malignancy among women worldwide. Almost all 342,000 deaths from take place low- and middle-income countries, accounting for 90 % deaths. Few studies use structural equation modeling comprehensively analyze predictors screening.
Language: Английский
Cancer Reports, Journal Year: 2022, Volume and Issue: 6(3)
Published: Dec. 21, 2022
Abstract Aim Among gynecological cancers, cervical cancer is the most common cause of cancer‐related death in developing countries. This study analyzes incidence, mortality, and burden using Global Burden Disease (GBD) 2019 study. Materials Methods The GBD (2019) data on was extracted from Health Data Exchange (GHDx) query tool. Age‐standardized rate (ASR) deaths, lost years life (YLLs), with disabilities (YLDs), adjusted (DALYs) women were extracted. globally for 204 countries groups based a socio‐demographic index (SDI), World Organization (WHO) regions, continents, Bank 22 regions. Results higher standardized age incidence lower SDI countries, Africa, African region (According to WHO), Sub‐Saharan Africa regions). highest deaths ASR low SDI, low‐income group, Organization), According classification, DALYs Low‐income then American region, Latin America & Caribbean‐WB (Based Conclusion In 2019, mostly affected socioeconomic status. Given that highly preventable, access screening services presence trained knowledgeable health care staff can reduce illness, suffering, caused by this malignancy. It recommended use national international potentials
Language: Английский
Citations
48
Health Science Reports, Journal Year: 2024, Volume and Issue: 7(1)
Published: Jan. 1, 2024
Abstract Background and Aim Endometrial cancer (EC) is the sixth most common among women worldwide. Since global studies are based on awareness of incidence trend, mortality, geographical diversity, level social development income countries, this study was conducted to investigate trend uterine (UC) in world 2019. Methods Age‐standardized rates (ASR) incidence, deaths, prevalence, disability‐adjusted life years (DALYs) UC, as well targeted risk factors, were extracted from Global Burden Disease (GBD) online database Pearson correlation coefficient SPSS 16 used calculate between factors ASR epidemiological indicators. Statistical significance considered p < 0.05. Results In 2019, age‐specific death rate UC peaking at 60–64 65–69 years, respectively. The highest age‐standardized per 100,000 people for has been reported Northern Mariana Islands, high sociodemographic index (SDI) World Bank High‐Income category, Europe continent Health Organization (WHO) regions found European Region. Grenada, SDI continent, WHO DALYs 53.54 inhabitants, which 48.49 cases related lost (YLLs) 5.05 lived with disability. Conclusion According GBD‐2019, DALY Europe. evidence traces diversity can be seen inequalities UC. Race, ethnicity, economic status, education awareness, co‐morbidities, access, grade, histological type tumor important causes inequality.
Language: Английский
Citations
11
Hereditas, Journal Year: 2025, Volume and Issue: 162(1)
Published: Feb. 10, 2025
Abstract Objectives The study investigates the role of Cell Division Cycle Associated (CDCA) genes in colorectal cancer (COAD) by analyzing their differential expression, epigenetic alterations, prognostic significance, and functional associations. Methodology This employed a detailed silico vitro experiments-based methodology. Results RT-qPCR assays reveal significantly elevated mRNA levels CDCA2, CDCA3, CDCA4, CDCA5, CDCA7, CDCA8 COAD cell lines compared to controls. Bisulfite sequencing indicates reduced promoter methylation CDCA gene promoters lines, suggesting an regulatory mechanism. Analysis large TCGA datasets confirms increased expression tissues. Survival analysis using cSurvival database demonstrates negative correlations between patient overall survival. Additionally, Lasso regression-based models predict survival outcomes patients. Investigating immune modulation, inversely correlates with infiltration modulators. miRNA-mRNA network identifies miRNAs targeting genes, validated showing up-regulation has-mir-10a-5p has-mir-20a-5p Drug sensitivity suggests resistance specific drugs patients expression. Furthermore, crucial states COAD, including “angiogenesis, apoptosis, differentiation, hypoxia, inflammation, metastasis.” Additional experiments revealed that CDCA2 CDCA3 knockdown SW480 SW629 cells proliferation colony formation while enhancing migration. Conclusion Overall, elucidates multifaceted progression, providing insights into potential diagnostic, prognostic, therapeutic implications.
Language: Английский
Citations
1
Medicina, Journal Year: 2023, Volume and Issue: 59(4), P. 704 - 704
Published: April 4, 2023
Introduction: The aim of this study is to analyze the available scientific evidence regarding quality life (QoL) and sexual function (SF) in patients affected by cervical cancer (CC) after surgical adjuvant treatments. Materials Methods: Preliminary research was conducted via electronic database (MEDLINE, PubMed Cochrane Library) with use a combination following keywords: SF, QoL, CC. principal findings considered present review were design, number included each study, information about malignancy (histology stage disease), questionnaires administered, concerning SF QoL. Results: All studies published between 2003-2022. selected consisted one randomized control seven observational (three prospective series), nine case studies. scores used focused on QOL, fatigue, psychological aspects. reported decreased QOL. most developed European Organization for Research Treatment Cancer Quality Life Questionnaire (EORTC QLQ-C30), Female Sexual Function Index (FSFI), Hospital Anxiety Depression scale (HADS), Distress Scale (FSDS). Discussion: In addition perception body image, several factors coexist influencing outcomes such as physical, hormonal, psychological. Conclusions: dysfunction CC treatment has multifactorial aetiology which negatively affects life. For these reasons, it important follow support multidisciplinary team (doctors, nurses, psychologists, dieticians) before therapy. This type tailored therapeutic approach should become standard. Women be informed possible vaginal changes menopausal symptoms surgery positive effects
Language: Английский
Citations
22
Molecular Biology Reports, Journal Year: 2024, Volume and Issue: 51(1)
Published: Feb. 8, 2024
Language: Английский
Citations
6
Diagnostics, Journal Year: 2024, Volume and Issue: 14(4), P. 451 - 451
Published: Feb. 19, 2024
Cervical cancer, primarily caused by high-risk human papillomavirus (HR-HPV) types 16 and 18, is a major global health concern. Persistent HR-HPV infection can progress from reversible precancerous lesions to invasive cervical which driven the oncogenic activity of (HPV) genes, particularly E6 E7. Traditional screening methods, including cytology HPV testing, have limited sensitivity specificity. This review explores application p16/Ki-67 dual-staining for cancer screening. advanced immunocytochemical method allows simultaneously detecting p16 Ki-67 proteins within epithelial cells, offering more specific approach triaging HPV-positive women. Dual staining traditional methods are compared, demonstrating their high negative predictive value but low The increased dual results in higher detection rates CIN2+ lesions, crucial preventing progression. However, its specificity may lead false-positive unnecessary biopsies. implications integrating into contemporary strategies, considering evolving landscape vaccination changes genotype prevalence, also discussed. New guidelines further research necessary elucidate long-term effects protocols.
Language: Английский
Citations
6
PLoS ONE, Journal Year: 2024, Volume and Issue: 19(8), P. e0309597 - e0309597
Published: Aug. 29, 2024
Background Despite the availability of effective HPV vaccines, their acceptance in Islamic countries is often influenced by religious beliefs, practices, and misconceptions. Objective This review aimed to identify current literature on beliefs any misconceptions toward vaccine within Organisation Cooperation (OIC) countries. Method Using key terms, a systematic search MEDLINE/PubMed, Embase, CINAHL yielded 23 studies that met inclusion exclusion criteria. The scope this included all research articles published English until October 31, 2023. A form based aim study was developed used extract data. Results highlights complexity relationship between uptake. findings reveal significant objections among number Muslims. Some them believe vaccines lead infertility sexual promiscuity, defy norms, are sneaky way inject good Muslims with haram ingredients, an abandonment righteous principles general. Conclusions Vaccine hesitancy result doubts regarding vaccine’s safety, necessity, compatibility beliefs. It recommended encourage uptake using public health strategies adopt holistic approach incorporates religious, cultural, social aspects.
Language: Английский
Citations
6
Thoracic Cancer, Journal Year: 2023, Volume and Issue: 14(18), P. 1668 - 1706
Published: May 1, 2023
This study aimed to describe the trends in incidence, mortality, and burden of tracheal, bronchial lung (TBL) cancer Asia from 2010 through 2019 compare with global other continental data.We collected TBL data Global Burden Disease (GBD) 49 countries territories Asia. For all locations, annual case age-standardized rates (ASRs) were used investigate prevalence, disability-adjusted life-years (DALYs) 2019. The relative difference (%) between years was show comparative variations ASRs for indicators studied.In 2019, more than 55% cases deaths occurred Asian countries. A total 57% patients lived almost 60% imposed on From incidences, deaths, prevalence cases, DALYs number increased over 1.34-, 1.31-, 1.26-fold, During this period, incidence rate (ASIR), death (ASDR), (ASPR), (DALYs ASR) decreased by 1, 3, 4, 4%, respectively. While at same time, decreasing trend these globally America Europe happened faster. In age-specific death, DALY peaking 65-74, 70-74, 65-69, 65-69 years, highest ASIR, ASDR, ASR observed East ASPR high-income Pacific Central experienced a ASIR South increasing only Asia, among high sociodemographic index (SDI) countries, Brunei Darussalam had Republic Korea ASPR. Among high-middle SDIs, Turkey Georgia; middle China Armenia; low-middle Mongolia Democratic People's ASPR, cancer. low SDI Pakistan cancer.Most occurs is slower regions. Therefore, implementation necessary measures order reduce process considered urgent.
Language: Английский
Citations
11
American Journal of Obstetrics and Gynecology, Journal Year: 2024, Volume and Issue: unknown
Published: Aug. 1, 2024
Language: Английский
Citations
4
BMC Infectious Diseases, Journal Year: 2025, Volume and Issue: 25(1)
Published: Jan. 28, 2025
Human Papillomavirus (HPV) is the most common sexually transmitted lower genital tract infection worldwide and main etiological factor of cervical cancer (CC). Since 2006, vaccines have been implemented to reduce CC-related morbidity mortality. This systematic review meta-analysis aimed evaluate prevalence infections by non-vaccine high-risk HPV (HR-HPV) types in women vaccinated against 16 18. used independent electronic databases – Lilacs, WHO, BDENF, State Department Health SP, Information Locator, IRIS, Coleciona Sistema Único de Saúde, BINACIS, IBECS, CUMED SciELO, on July 14, 2023. Observational studies that evaluated unvaccinated HR-HPV were included. Intervention effects expressed as ratios (PR). Forest plots visualize vaccination effects. The study protocol was previously registered PROSPERO, under code CRD42023440610. Of 7,051 studies, 31 met analysis criteria. A total 59,035 eligible for this review. results showed a high types, regardless status. For 31/33/45 (PR = 0.60 [0.40–0.91]), HPV31 0.47 [0.31–0.72]), 45 0.38 [0.22–0.69]), positive random effect found. women, 31/33/45, suggesting cross-protective these viral types.
Language: Английский
Citations
0