Molecules,
Год журнала:
2020,
Номер
25(16), С. 3579 - 3579
Опубликована: Авг. 6, 2020
One
central
challenge
for
XXI
century
chemists
is
the
development
of
sustainable
processes
that
do
not
represent
a
risk
either
to
humanity
or
environment.
In
this
regard,
search
more
efficient
and
clean
alternatives
achieve
chemical
activation
molecules
involved
in
transformations
has
played
prominent
role
recent
years.
The
use
microwave
UV-Vis
light
irradiation,
mechanochemical
already
widespread
many
laboratories.
Nevertheless,
an
additional
condition
“green”
comes
from
point
view
so-called
atom
economy.
removal
solvents
reactions
generally
leads
cleaner,
economical
processes.
This
review
presents
several
illustrative
applications
protocols
synthesis
organic
compounds
under
solvent-free
reaction
conditions.
Chemical Reviews,
Год журнала:
2018,
Номер
119(4), С. 2192 - 2452
Опубликована: Ноя. 27, 2018
C–H
activation
has
surfaced
as
an
increasingly
powerful
tool
for
molecular
sciences,
with
notable
applications
to
material
crop
protection,
drug
discovery,
and
pharmaceutical
industries,
among
others.
Despite
major
advances,
the
vast
majority
of
these
functionalizations
required
precious
4d
or
5d
transition
metal
catalysts.
Given
cost-effective
sustainable
nature
earth-abundant
first
row
metals,
development
less
toxic,
inexpensive
3d
catalysts
gained
considerable
recent
momentum
a
significantly
more
environmentally-benign
economically-attractive
alternative.
Herein,
we
provide
comprehensive
overview
on
until
summer
2018.
Angewandte Chemie International Edition,
Год журнала:
2019,
Номер
59(3), С. 1018 - 1029
Опубликована: Июль 11, 2019
Abstract
Mechanochemical
solvent‐free
reactions
by
milling,
grinding
or
other
types
of
mechanical
action
have
emerged
as
a
viable
alternative
to
solution
chemistry.
Mechanochemistry
offers
not
only
possibility
eliminate
the
need
for
bulk
solvent
use,
and
reduce
generation
waste,
but
it
also
unlocks
door
different
reaction
environment
in
which
synthetic
strategies,
molecules
previously
accessible
solution,
can
be
achieved.
This
Minireview
examines
potential
mechanochemistry
chemical
materials
synthesis,
providing
cross‐section
recent
developments
using
ball
milling
formation
based
on
covalent
coordination
bonds.
ChemSusChem,
Год журнала:
2021,
Номер
14(10), С. 2145 - 2162
Опубликована: Апрель 9, 2021
In
recent
years,
mechanochemistry
has
been
growing
into
a
widely
accepted
alternative
for
chemical
synthesis.
addition
to
their
efficiency
and
practicality,
mechanochemical
reactions
are
also
recognized
sustainability.
The
association
between
Green
Chemistry
often
originates
from
the
solvent-free
nature
of
most
protocols,
which
can
reduce
waste
production.
However,
satisfies
more
than
one
Principles
Chemistry.
this
Review
we
will
present
series
examples
that
clearly
illustrate
how
significantly
contribute
fulfillment
in
holistic
manner.
Angewandte Chemie International Edition,
Год журнала:
2018,
Номер
58(11), С. 3285 - 3299
Опубликована: Ноя. 12, 2018
Abstract
In
recent
years,
the
application
of
mechanical
energy
to
chemical
systems
has
repeatedly
proven
beneficial
facilitate
transformations
in
various
areas
chemistry.
Today,
a
systematic
body
evidence
indicates
that
mechanochemistry
holds
great
promise
become
game‐changer
synthesis.
Not
only
does
permit
access
products
are
inaccessible
by
established
means
(e.g.
purely
thermal
activation),
mechanochemical
reactions
often
outperform
their
solution‐based
counterparts
terms
sustainability.
Most
carried
out
ball
milling
techniques
involve
solids
and
liquids,
but
number
with
gaseous
reactants
is
increasing.
The
aim
this
Minireview
provide
an
overview
involving
samples
highlight
advances
technology
for
safe
handling
reagents.
Examples
proceeding
at
interface
solid–/liquid–/gas–gas
led
significant
improvements
reactivity
or
selectivity
will
also
be
highlighted.
Advanced Synthesis & Catalysis,
Год журнала:
2021,
Номер
363(5), С. 1246 - 1271
Опубликована: Янв. 21, 2021
Abstract
Mechanochemical
reactions
by
milling,
grinding
or
other
types
of
mechanical
action
have
emerged
as
a
salient
green
approach
because
its
wide
applications
towards
academic
and
industrial
chemical
communities
in
sustainable
solvent‐free/solvent‐less
processes.
Liquid‐assisted
(LAG)
an
extension
traditional
solvent‐free
mechanochemical
techniques
which
small
amount
liquid
is
used
additive
to
enhance
and/or
control
reactivity,
has
been
fruitfully
applied
the
screening
inclusion
compounds,
cocrystals,
salts,
solvates,
polymorphs.
However,
utilization
this
important
technique
synthesis
pharmaceutically
biologically
relevant
targets
was
not
adequately
investigated.
This
review
article
summarizes
overview
latest
development
LAG
approaches
active
pharmaceutical
ingredients
(API)
drug‐like
fragments,
highlights
superiority
versus
conventional
syntheses.
magnified
image
Angewandte Chemie,
Год журнала:
2019,
Номер
132(3), С. 1030 - 1041
Опубликована: Июль 11, 2019
Abstract
Mechanochemical
solvent‐free
reactions
by
milling,
grinding
or
other
types
of
mechanical
action
have
emerged
as
a
viable
alternative
to
solution
chemistry.
Mechanochemistry
offers
not
only
possibility
eliminate
the
need
for
bulk
solvent
use,
and
reduce
generation
waste,
but
it
also
unlocks
door
different
reaction
environment
in
which
synthetic
strategies,
molecules
previously
accessible
solution,
can
be
achieved.
This
Minireview
examines
potential
mechanochemistry
chemical
materials
synthesis,
providing
cross‐section
recent
developments
using
ball
milling
formation
based
on
covalent
coordination
bonds.
ACS Sustainable Chemistry & Engineering,
Год журнала:
2020,
Номер
8(24), С. 8881 - 8893
Опубликована: Июнь 10, 2020
Recently,
the
application
of
mechanochemical
strategies
in
organic
synthesis
has
attracted
attention
both
academic
and
industrial
chemical
communities.
The
high
efficiency
low
environmental
impact
processes
performed
by
mechanical
activation
positioned
methods
among
salient
green
techniques
since
it
allows
accomplishment
most
sustainable
chemistry
principles.
In
particular,
mechanochemistry
been
used
as
a
tool
for
active
pharmaceutical
ingredients
via
or
through
biocatalytic
protocols
using
enzymes
with
outstanding
results,
while
simultaneously
increasing
sustainability
process.
this
regard,
main
purpose
present
perspective
is
to
summarize
current
developments
mechanoenzymatic
approaches
pharmacologically
compounds.
importance
these
so-called
medicinal
field
will
be
highlighted.
Chemical Communications,
Год журнала:
2022,
Номер
58(11), С. 1661 - 1671
Опубликована: Янв. 1, 2022
Direct
mechanocatalysis
(DM)
describes
solvent-free
catalytic
reactions
that
are
initiated
by
mechanical
forces
in
mechanochemical
reactors
such
as
ball
mills.
The
distinctive
feature
of
DM
is
the
milling
materials,
