Salient Achievements in Synthetic Organic Chemistry Enabled by Mechanochemical Activation DOI
Eusebio Juaristi, C.G. Ávila-Ortíz

Synthesis, Год журнала: 2023, Номер 55(16), С. 2439 - 2459

Опубликована: Май 3, 2023

Abstract Although known for millennia, it is only recently that mechanochemistry has received serious attention by chemists. Indeed, during the past 15 years an extraordinary number of reports concerning solid-state chemical transformations through grinding and milling techniques have been recorded. This short review discusses circumstances led this renaissance, highlighting present intense interest in so-called green chemistry, enabling capacity to handle insoluble substrates, identification profound influence additives can on mechanochemically activated reactions. The core account focuses salient developments synthetic organic especially amino acid peptide­ mechanosynthesis, successful employment mechanochemical activation combination with asymmetric organocatalysis, promising enzymatic whole cell biocatalysis, remarkable achievement multicomponent selective reactions via complex, multistep reaction pathways, mechanosynthesis representative heterocycles. final section comments some pending tasks area, such as scaling-up processes be practical use industry, requirement easier more efficient control parameters monitoring devices, consequently careful analysis additional procedures a proper understanding phenomena. 1 Introduction 2 Brief History Mechanochemistry 3 Milling Equipment Reaction Parameters 4 Attributes That Propelled Its Present Renaissance 4.1 Enormous Attention Being Presently Paid Sustainable Chemistry 4.2 Reduced Energy Consumption 4.3 Additive-Based 4.4 Handling Insoluble Reactants 4.5 ‘Impossible’ Reactions Are Successful 4.6 Air- Water-Sensitive Reagents Ball 5 Salient Developments Mechanochemical Activation Synthetic Organic 5.1 Amino Acid Peptide Mechanosynthesis 5.2 Asymmetric Synthesis Organocatalysis under Ball-Milling Conditions 5.3 Mechanoenzymology 5.4 Multicomponent Activated 5.5 Heterocycles Modification 6 Future Directions 6.1 Scaling-Up Protocols 6.2 Temperature-Controlled 6.3 Understanding Transformations 6.4 Emerging Techniques 7 Conclusions

Язык: Английский

Mechanochemistry for Synthesis DOI
Tomislav Friščić, Cristina Mottillo, Hatem M. Titi

и другие.

Angewandte Chemie International Edition, Год журнала: 2019, Номер 59(3), С. 1018 - 1029

Опубликована: Июль 11, 2019

Abstract Mechanochemical solvent‐free reactions by milling, grinding or other types of mechanical action have emerged as a viable alternative to solution chemistry. Mechanochemistry offers not only possibility eliminate the need for bulk solvent use, and reduce generation waste, but it also unlocks door different reaction environment in which synthetic strategies, molecules previously accessible solution, can be achieved. This Minireview examines potential mechanochemistry chemical materials synthesis, providing cross‐section recent developments using ball milling formation based on covalent coordination bonds.

Язык: Английский

Процитировано

862

Organic Electrochemistry: Molecular Syntheses with Potential DOI Creative Commons
Cuiju Zhu, Nate W. J. Ang, Tjark H. Meyer

и другие.

ACS Central Science, Год журнала: 2021, Номер 7(3), С. 415 - 431

Опубликована: Март 9, 2021

Efficient and selective molecular syntheses are paramount to

Язык: Английский

Процитировано

589

Sustainability Assessment of Mechanochemistry by Using the Twelve Principles of Green Chemistry DOI
Karen J. Ardila‐Fierro, José G. Hernández

ChemSusChem, Год журнала: 2021, Номер 14(10), С. 2145 - 2162

Опубликована: Апрель 9, 2021

In recent years, mechanochemistry has been growing into a widely accepted alternative for chemical synthesis. addition to their efficiency and practicality, mechanochemical reactions are also recognized sustainability. The association between Green Chemistry often originates from the solvent-free nature of most protocols, which can reduce waste production. However, satisfies more than one Principles Chemistry. this Review we will present series examples that clearly illustrate how significantly contribute fulfillment in holistic manner.

Язык: Английский

Процитировано

471

Redox reactions of small organic molecules using ball milling and piezoelectric materials DOI
Koji Kubota, Yadong Pang, Akira Miura

и другие.

Science, Год журнала: 2019, Номер 366(6472), С. 1500 - 1504

Опубликована: Дек. 20, 2019

Over the past decade, photoredox catalysis has harnessed light energy to accelerate bond-forming reactions. We postulated that a complementary method for redox-activation of small organic molecules in response applied mechanical could be developed through piezoelectric effect. Here, we report agitation materials via ball milling reduces aryl diazonium salts. This mechanoredox system can arylation and borylation reactions under mechanochemical conditions.

Язык: Английский

Процитировано

435

Metal-Mediated and Metal-Catalyzed Reactions Under Mechanochemical Conditions DOI Creative Commons
Andrea Porcheddu, Evelina Colacino, Lidia De Luca

и другие.

ACS Catalysis, Год журнала: 2020, Номер 10(15), С. 8344 - 8394

Опубликована: Май 27, 2020

The extraordinary impact of metal-based complexes on synthetic methods is still recognized nowadays, and attempts are currently undertaken to further extend the use metal-assisted chemistry environmentally friendly processes within strongly invoked green paradigm. In recent years, mechanochemistry seems provide attractive responses with processing having origins lost in mists time. Focusing panorama organic synthesis, this Review highlights some recently developed mechanochemical reactions introduce reader into fascinating, quite unexplored world mechanochemistry.

Язык: Английский

Процитировано

257

The many flavours of mechanochemistry and its plausible conceptual underpinnings DOI
Robert T. O’Neill, Roman Boulatov

Nature Reviews Chemistry, Год журнала: 2021, Номер 5(3), С. 148 - 167

Опубликована: Фев. 2, 2021

Язык: Английский

Процитировано

254

Liquid‐Assisted Grinding Mechanochemistry in the Synthesis of Pharmaceuticals DOI

Ping Ying,

Jingbo Yu, Weike Su

и другие.

Advanced Synthesis & Catalysis, Год журнала: 2021, Номер 363(5), С. 1246 - 1271

Опубликована: Янв. 21, 2021

Abstract Mechanochemical reactions by milling, grinding or other types of mechanical action have emerged as a salient green approach because its wide applications towards academic and industrial chemical communities in sustainable solvent‐free/solvent‐less processes. Liquid‐assisted (LAG) an extension traditional solvent‐free mechanochemical techniques which small amount liquid is used additive to enhance and/or control reactivity, has been fruitfully applied the screening inclusion compounds, cocrystals, salts, solvates, polymorphs. However, utilization this important technique synthesis pharmaceutically biologically relevant targets was not adequately investigated. This review article summarizes overview latest development LAG approaches active pharmaceutical ingredients (API) drug‐like fragments, highlights superiority versus conventional syntheses. magnified image

Язык: Английский

Процитировано

251

Mechanochemistry for Synthesis DOI
Tomislav Friščić, Cristina Mottillo, Hatem M. Titi

и другие.

Angewandte Chemie, Год журнала: 2019, Номер 132(3), С. 1030 - 1041

Опубликована: Июль 11, 2019

Abstract Mechanochemical solvent‐free reactions by milling, grinding or other types of mechanical action have emerged as a viable alternative to solution chemistry. Mechanochemistry offers not only possibility eliminate the need for bulk solvent use, and reduce generation waste, but it also unlocks door different reaction environment in which synthetic strategies, molecules previously accessible solution, can be achieved. This Minireview examines potential mechanochemistry chemical materials synthesis, providing cross‐section recent developments using ball milling formation based on covalent coordination bonds.

Язык: Английский

Процитировано

234

Mechanochemical Synthesis of Catalytic Materials DOI Creative Commons
Amol P. Amrute, Jacopo De Bellis, Michael Felderhoff

и другие.

Chemistry - A European Journal, Год журнала: 2021, Номер 27(23), С. 6819 - 6847

Опубликована: Янв. 15, 2021

The mechanochemical synthesis of nanomaterials for catalytic applications is a growing research field due to its simplicity, scalability, and eco-friendliness. Besides, it provides materials with distinct features, such as nanocrystallinity, high defect concentration, close interaction the components in system, which are, most cases, unattainable by conventional routes. Consequently, this has recently become highly popular, particularly preparation various applications, ranging from chemical production over energy conversion catalysis environmental protection. In Review, recent studies on mechanochemistry are discussed. Emphasis placed straightforwardness route-in contrast more synthesis-in fabricating materials, otherwise often require harsh conditions. Distinct material properties achieved related their improved performance.

Язык: Английский

Процитировано

213

Challenges and opportunities in the bottom-up mechanochemical synthesis of noble metal nanoparticles DOI Creative Commons
Paulo F. M. de Oliveira, Roberto M. Torresi, Franziska Emmerling

и другие.

Journal of Materials Chemistry A, Год журнала: 2020, Номер 8(32), С. 16114 - 16141

Опубликована: Янв. 1, 2020

This review covers the fundamentals and recent developments on mechanochemical synthesis of noble metal nanoparticles.

Язык: Английский

Процитировано

202