Synthesis,
Год журнала:
2023,
Номер
55(16), С. 2439 - 2459
Опубликована: Май 3, 2023
Abstract
Although
known
for
millennia,
it
is
only
recently
that
mechanochemistry
has
received
serious
attention
by
chemists.
Indeed,
during
the
past
15
years
an
extraordinary
number
of
reports
concerning
solid-state
chemical
transformations
through
grinding
and
milling
techniques
have
been
recorded.
This
short
review
discusses
circumstances
led
this
renaissance,
highlighting
present
intense
interest
in
so-called
green
chemistry,
enabling
capacity
to
handle
insoluble
substrates,
identification
profound
influence
additives
can
on
mechanochemically
activated
reactions.
The
core
account
focuses
salient
developments
synthetic
organic
especially
amino
acid
peptide
mechanosynthesis,
successful
employment
mechanochemical
activation
combination
with
asymmetric
organocatalysis,
promising
enzymatic
whole
cell
biocatalysis,
remarkable
achievement
multicomponent
selective
reactions
via
complex,
multistep
reaction
pathways,
mechanosynthesis
representative
heterocycles.
final
section
comments
some
pending
tasks
area,
such
as
scaling-up
processes
be
practical
use
industry,
requirement
easier
more
efficient
control
parameters
monitoring
devices,
consequently
careful
analysis
additional
procedures
a
proper
understanding
phenomena.
1
Introduction
2
Brief
History
Mechanochemistry
3
Milling
Equipment
Reaction
Parameters
4
Attributes
That
Propelled
Its
Present
Renaissance
4.1
Enormous
Attention
Being
Presently
Paid
Sustainable
Chemistry
4.2
Reduced
Energy
Consumption
4.3
Additive-Based
4.4
Handling
Insoluble
Reactants
4.5
‘Impossible’
Reactions
Are
Successful
4.6
Air-
Water-Sensitive
Reagents
Ball
5
Salient
Developments
Mechanochemical
Activation
Synthetic
Organic
5.1
Amino
Acid
Peptide
Mechanosynthesis
5.2
Asymmetric
Synthesis
Organocatalysis
under
Ball-Milling
Conditions
5.3
Mechanoenzymology
5.4
Multicomponent
Activated
5.5
Heterocycles
Modification
6
Future
Directions
6.1
Scaling-Up
Protocols
6.2
Temperature-Controlled
6.3
Understanding
Transformations
6.4
Emerging
Techniques
7
Conclusions
Angewandte Chemie International Edition,
Год журнала:
2019,
Номер
59(3), С. 1018 - 1029
Опубликована: Июль 11, 2019
Abstract
Mechanochemical
solvent‐free
reactions
by
milling,
grinding
or
other
types
of
mechanical
action
have
emerged
as
a
viable
alternative
to
solution
chemistry.
Mechanochemistry
offers
not
only
possibility
eliminate
the
need
for
bulk
solvent
use,
and
reduce
generation
waste,
but
it
also
unlocks
door
different
reaction
environment
in
which
synthetic
strategies,
molecules
previously
accessible
solution,
can
be
achieved.
This
Minireview
examines
potential
mechanochemistry
chemical
materials
synthesis,
providing
cross‐section
recent
developments
using
ball
milling
formation
based
on
covalent
coordination
bonds.
ChemSusChem,
Год журнала:
2021,
Номер
14(10), С. 2145 - 2162
Опубликована: Апрель 9, 2021
In
recent
years,
mechanochemistry
has
been
growing
into
a
widely
accepted
alternative
for
chemical
synthesis.
addition
to
their
efficiency
and
practicality,
mechanochemical
reactions
are
also
recognized
sustainability.
The
association
between
Green
Chemistry
often
originates
from
the
solvent-free
nature
of
most
protocols,
which
can
reduce
waste
production.
However,
satisfies
more
than
one
Principles
Chemistry.
this
Review
we
will
present
series
examples
that
clearly
illustrate
how
significantly
contribute
fulfillment
in
holistic
manner.
Science,
Год журнала:
2019,
Номер
366(6472), С. 1500 - 1504
Опубликована: Дек. 20, 2019
Over
the
past
decade,
photoredox
catalysis
has
harnessed
light
energy
to
accelerate
bond-forming
reactions.
We
postulated
that
a
complementary
method
for
redox-activation
of
small
organic
molecules
in
response
applied
mechanical
could
be
developed
through
piezoelectric
effect.
Here,
we
report
agitation
materials
via
ball
milling
reduces
aryl
diazonium
salts.
This
mechanoredox
system
can
arylation
and
borylation
reactions
under
mechanochemical
conditions.
ACS Catalysis,
Год журнала:
2020,
Номер
10(15), С. 8344 - 8394
Опубликована: Май 27, 2020
The
extraordinary
impact
of
metal-based
complexes
on
synthetic
methods
is
still
recognized
nowadays,
and
attempts
are
currently
undertaken
to
further
extend
the
use
metal-assisted
chemistry
environmentally
friendly
processes
within
strongly
invoked
green
paradigm.
In
recent
years,
mechanochemistry
seems
provide
attractive
responses
with
processing
having
origins
lost
in
mists
time.
Focusing
panorama
organic
synthesis,
this
Review
highlights
some
recently
developed
mechanochemical
reactions
introduce
reader
into
fascinating,
quite
unexplored
world
mechanochemistry.
Advanced Synthesis & Catalysis,
Год журнала:
2021,
Номер
363(5), С. 1246 - 1271
Опубликована: Янв. 21, 2021
Abstract
Mechanochemical
reactions
by
milling,
grinding
or
other
types
of
mechanical
action
have
emerged
as
a
salient
green
approach
because
its
wide
applications
towards
academic
and
industrial
chemical
communities
in
sustainable
solvent‐free/solvent‐less
processes.
Liquid‐assisted
(LAG)
an
extension
traditional
solvent‐free
mechanochemical
techniques
which
small
amount
liquid
is
used
additive
to
enhance
and/or
control
reactivity,
has
been
fruitfully
applied
the
screening
inclusion
compounds,
cocrystals,
salts,
solvates,
polymorphs.
However,
utilization
this
important
technique
synthesis
pharmaceutically
biologically
relevant
targets
was
not
adequately
investigated.
This
review
article
summarizes
overview
latest
development
LAG
approaches
active
pharmaceutical
ingredients
(API)
drug‐like
fragments,
highlights
superiority
versus
conventional
syntheses.
magnified
image
Angewandte Chemie,
Год журнала:
2019,
Номер
132(3), С. 1030 - 1041
Опубликована: Июль 11, 2019
Abstract
Mechanochemical
solvent‐free
reactions
by
milling,
grinding
or
other
types
of
mechanical
action
have
emerged
as
a
viable
alternative
to
solution
chemistry.
Mechanochemistry
offers
not
only
possibility
eliminate
the
need
for
bulk
solvent
use,
and
reduce
generation
waste,
but
it
also
unlocks
door
different
reaction
environment
in
which
synthetic
strategies,
molecules
previously
accessible
solution,
can
be
achieved.
This
Minireview
examines
potential
mechanochemistry
chemical
materials
synthesis,
providing
cross‐section
recent
developments
using
ball
milling
formation
based
on
covalent
coordination
bonds.
Chemistry - A European Journal,
Год журнала:
2021,
Номер
27(23), С. 6819 - 6847
Опубликована: Янв. 15, 2021
The
mechanochemical
synthesis
of
nanomaterials
for
catalytic
applications
is
a
growing
research
field
due
to
its
simplicity,
scalability,
and
eco-friendliness.
Besides,
it
provides
materials
with
distinct
features,
such
as
nanocrystallinity,
high
defect
concentration,
close
interaction
the
components
in
system,
which
are,
most
cases,
unattainable
by
conventional
routes.
Consequently,
this
has
recently
become
highly
popular,
particularly
preparation
various
applications,
ranging
from
chemical
production
over
energy
conversion
catalysis
environmental
protection.
In
Review,
recent
studies
on
mechanochemistry
are
discussed.
Emphasis
placed
straightforwardness
route-in
contrast
more
synthesis-in
fabricating
materials,
otherwise
often
require
harsh
conditions.
Distinct
material
properties
achieved
related
their
improved
performance.
