Journal of Cellular and Molecular Medicine,
Год журнала:
2024,
Номер
28(24)
Опубликована: Дек. 1, 2024
ABSTRACT
Emerging
evidence
highlights
certain
long
noncoding
RNAs
(lncRNAs)
transcribed
from
or
interacting
with
super‐enhancer
(SE)
regulatory
elements.
These
lncRNAs,
known
as
SE‐lncRNAs,
are
strongly
linked
to
cancer
and
regulate
progression
through
multiple
interactions
downstream
targets.
The
expression
of
SE‐lncRNAs
is
controlled
by
various
transcription
factors
(TFs),
dysregulation
these
TFs
can
contribute
development.
In
this
review,
we
discuss
the
characteristics,
classification
subcellular
distribution
summarise
role
key
in
regulation
SE‐lncRNAs.
Moreover,
examine
distinct
functions
potential
mechanisms
progression.
Cell Communication and Signaling,
Год журнала:
2025,
Номер
23(1)
Опубликована: Май 30, 2025
Enhancers,
as
distal
cis-regulatory
elements
in
the
genome,
have
a
pivotal
influence
on
orchestrating
precise
gene
expression.
Enhancer
RNAs
(eRNAs),
transcribed
from
active
enhancer
regions,
are
increasingly
recognized
key
regulators
of
transcription.
N6-methyladenosine
(m6A),
most
plentiful
internal
modification
eukaryotic
mRNAs,
has
garnered
significant
research
interest
recent
years.
With
advancements
high-throughput
sequencing
technologies,
it
been
established
that
m6A
modifications
also
present
eRNAs.
An
accumulative
body
evidence
demonstrates
aberrant
enhancers,
eRNAs,
and
intimately
connected
with
carcinoma
onset,
progression,
invasion,
metastasis,
treatment
response,
drug
resistance,
prognosis.
However,
underlying
molecular
mechanisms
governing
eRNAs
cancer
remain
elusive.
Here,
we
review
synthesize
current
understanding
regulatory
roles
cancer.
Furthermore,
investigate
possible
tumorigenesis
based
existing
literature,
offering
novel
perspectives
directions
for
future
epigenetic
cells.
N6-methyladenosine
(M6A)
modification
is
the
most
abundant
internal
chemical
on
RNA
molecules
in
eukaryotes
and
can
affect
mRNA
metabolism
regulate
transcription,
nuclear
export,
splicing,
degradation,
translation,
ets,
has
a
significant
impact
various
aspects
of
physiology
or
pathobiology.
Radiotherapy
common
measure
tumor
treatment,
variety
cellular
intrinsic
mechanisms
responses
cells
to
ionizing
radiation
(IR)
effectiveness
cancer
radiotherapy.
In
this
review,
we
summarize
discuss
recent
advances
about
roles
M6A
methylation
radiation-induced
DNA
damage
response,
outcomes
Insights
into
biology
may
facilitate
improvement
therapeutic
strategies
for
radiotherapy
as
well
radioprotection
normal
tissues.
Frontiers in Pharmacology,
Год журнала:
2024,
Номер
15
Опубликована: Апрель 12, 2024
Lung
cancer
is
still
one
of
the
deadliest
malignancies
today,
and
most
patients
with
advanced
lung
pass
away
from
disease
progression
that
uncontrollable
by
medications.
Super-enhancers
(SEs)
are
large
clusters
enhancers
in
genome’s
non-coding
sequences
actively
trigger
transcription.
Although
SEs
have
just
been
identified
over
past
10
years,
their
intricate
structure
crucial
role
determining
cell
identity
promoting
tumorigenesis
increasingly
coming
to
light.
Here,
we
review
structural
composition
SEs,
auto-regulatory
circuits,
control
mechanisms
downstream
genes
pathways,
characterization
subgroups
classified
according
cancer.
Additionally,
discuss
therapeutic
targets,
several
small-molecule
inhibitors,
available
treatment
options
for
Combination
therapies
demonstrated
considerable
advantages
preclinical
models,
anticipate
these
drugs
will
soon
enter
clinical
studies
benefit
patients.
Abstract
Sow
fertility
is
an
economically
important
quantitative
trait.
Hundreds
of
trait
loci
(QTLs)
containing
tens
thousands
potential
candidate
genes
are
excavated.
However,
among
these
genes,
non‐coding
RNAs
including
long
(lncRNAs)
often
overlooked.
Here,
it
reported
that
NORSF
a
novel
causal
lncRNA
for
sow
traits
in
QTLs.
QTLs
characterized
at
the
genome‐wide
level
and
identified
4,630
lncRNAs,
with
13
differentially
expressed
during
follicular
atresia.
,
involved
granulosa
cell
(sGC)
function,
as
gene
G
to
A
transversion
128
nt
its
transcript
shown
be
markedly
associated
traits.
Mechanistically,
after
forming
RNA:dsDNA
triplexes
promoter
Caspase8
allele
binds
RNA‐binding
protein
(RBP)
NR2C1
recruits
induce
transcription
sGCs.
Functionally,
this
leads
loss
inducing
effect
on
sGC
apoptosis
by
inactivating
death
receptor‐mediated
apoptotic
pathway.
This
study
can
used
genetic
improvement
Abstract
Advanced
metastasis
of
hepatocellular
carcinoma
(HCC)
significantly
contributes
to
high
death
rates
among
patients.
The
efficiency
targeted
therapies
and
chemotherapeutic
agents
shows
individual
variability.
Therefore,
there
is
no
effective
treatment
for
advanced
HCC.
Zinc
finger
proteins
(ZFPs)
are
known
be
crucial
in
various
tumors,
especially
on
In
our
study,
we
verified
that
ZFP41
could
suppress
the
progression
HCC
through
vitro
vivo
experiments.
During
past
years,
N6‐methyladenine
(m
6
A)
regulation
has
also
been
increasingly
reported
To
investigate
whether
regulated
via
m
A
methylation,
results
showed
YTHDF3
bound
mRNA
degrade
it.
Subsequently,
further
elucidate
function
ZFP41,
identified
Snail,
a
well‐known
oncogenic
molecule,
RNA‐seq.
As
canonical
component
epithelial‐to‐mesenchymal
transition
(EMT)
pathway,
Snail
plays
pivotal
role
critical
marker
tumor
invasion
metastasis.
Our
inhibit
EMT
pathway
its
transcriptional
repression.
conclusion,
study
revealed
potential
prognostic
element
patients
with
HCC,
targeting
might
used
translational
clinical
applications
as
promising
therapeutic
target.
Cell Death Discovery,
Год журнала:
2024,
Номер
10(1)
Опубликована: Дек. 18, 2024
Abstract
Nasopharyngeal
carcinoma
(NPC)
is
a
distinct
type
of
head
and
neck
squamous
cell
prevalent
in
Southern
China,
Southeast
Asia,
North
Africa.
Despite
advances
treatment
options,
the
prognosis
for
advanced
NPC
remains
poor,
underscoring
urgent
need
to
explore
its
underlying
mechanisms
develop
novel
therapeutic
strategies.
Epigenetic
alterations
have
been
shown
play
key
role
progression.
Recent
studies
indicate
that
dysregulation
RNA
modifications
specifically
affects
tumor-related
transcripts,
influencing
various
oncogenic
processes.
This
review
provides
comprehensive
overview
altered
their
regulators
NPC,
with
focus
on
m
6
A
regulatory
mechanisms.
We
discuss
how
modification
influences
gene
expression
initiation
progression
at
molecular
level,
analyzing
impact
cancer-related
biological
functions.
Understanding
these
could
reveal
new
biomarkers
targets
offering
promising
directions
future
research
precision
medicine.
