Journal of Cellular and Molecular Medicine,
Год журнала:
2024,
Номер
28(24)
Опубликована: Дек. 1, 2024
ABSTRACT
Emerging
evidence
highlights
certain
long
noncoding
RNAs
(lncRNAs)
transcribed
from
or
interacting
with
super‐enhancer
(SE)
regulatory
elements.
These
lncRNAs,
known
as
SE‐lncRNAs,
are
strongly
linked
to
cancer
and
regulate
progression
through
multiple
interactions
downstream
targets.
The
expression
of
SE‐lncRNAs
is
controlled
by
various
transcription
factors
(TFs),
dysregulation
these
TFs
can
contribute
development.
In
this
review,
we
discuss
the
characteristics,
classification
subcellular
distribution
summarise
role
key
in
regulation
SE‐lncRNAs.
Moreover,
examine
distinct
functions
potential
mechanisms
progression.
Research Square (Research Square),
Год журнала:
2024,
Номер
unknown
Опубликована: Май 2, 2024
Abstract
The
objective
of
this
study
was
to
construct
a
prognostic
model
and
medicine
therapeutic
response
by
utilizing
mitochondrial
energy
metabolism-related
genes
(MMRGs),
thus
establishing
risk
score
for
colorectal
cancer
(CRC).
Based
on
the
TCGA-CRC
GEO
data
set,
MMRGs
expression
levels
were
identified
clustering
analysis.
10
differential
used
RiskScore
Cox
regression.
GSE
39582
set
validation.
clinical
characteristics,survival
characteristics,SNV,CNV,methylation,
immune
features,
potential
benefits
chemotherapy
drugs
analyzed
two
groups.
constructed
based
ACOX1,
ATP6V1G2,
COX7A1,
CPT2,
DLAT,
ECGS1,
ECI2,
NDUFA1,
PPA2,
SUCLG2.
Patients
in
low
group
exhibited
superior
overall
survival.
In
addition,
Univariate
regression
analysis
Multivariate
demonstrated
that
score,
stage
lymphatic
invasion
can
serve
as
independent
factors.Trametinib
positive
correlations
between
IC50
values
levels,which
may
be
more
sensitive
drugs.
Mitochondrial
Energy
-Related
Genes
promising
biomarker
distinguish
CRC
prognosis,
sensitivity
Research Square (Research Square),
Год журнала:
2024,
Номер
unknown
Опубликована: Июнь 6, 2024
Abstract
Colorectal
cancer
(CRC)
is
a
common
with
high
mortality
rates
worldwide.
Disulfidptosis
an
emerging
mode
of
cell
death.
In
this
study,
disulfidptosis-related
lncRNAs
were
identified
by
screening
and
incorporated
into
prognostic
model
to
predict
the
prognosis
immunotherapy
response
colorectal
(CRC),
providing
new
effective
guide
for
clinical
decision
making.
Transcriptome
data
CRC
patients
normal
controls
obtained
from
The
Cancer
Genome
Atlas
(TCGA).
Pearson
correlation,
Cox
least
absolute
shrinkage
selection
operator
(LASSO)
regression
analyses
used
identify
lncRNAs.
A
risk
scoring
was
constructed,
its
predictive
performance
comprehensively
validated.
An
accurate
nomogram
constructed
prediction.
Model
reliability
verified
via
principal
component,
survival
receiver
operating
characteristic
(ROC)
curve
analyses.
GO
analysis
GSEA
cellular
pathways
relevant
model.
Immune
infiltration
studied
ESTIMATE
CIBERSORT
algorithms.
association
tumor
mutational
burden
(TMB)
model-derived
scores
assessed
using
single-nucleotide
variant
data.
Finally,
tThe
value
evaluated
through
GDSC
CTRP
databases,
drugs
predicted.
containing
9
(ATP2A1-AS1,
AC011815.1,
AC013652.1,
AC109992.2,
AC069549.1,
AC005034.5,
SUCLG2-AS1,
AP003555.1
AL590101.1)
successfully
constructed.
There
significant
difference
in
between
high-risk
low-risk
groups
(based
on
median
score)
training
validation
datasets.
score
serves
as
independent
factor
when
combined
variables.
revealed
that
group
enriched
processes
epidermis
development,
kidney
differentiation
skin
development.
could
stratify
two
distinct
groups.
independently
predicted
poor
overall
correlated
reduced
immune
infiltration,
TMB,
decreased
activity.
checkpoint
blockade
might
improve
patients,
whereas
be
more
responsive
targeted
therapy
diverse
kinase
inhibitors.
summary,
we
established
lncRNA
holds
promise
reliable
marker
can
also
landscape
response.
Non-coding RNA Research,
Год журнала:
2024,
Номер
10, С. 198 - 205
Опубликована: Окт. 10, 2024
Cardiovascular
diseases
(CVD)
are
widely
recognized
as
a
leading
cause
of
death
worldwide;
however,
early
diagnosis
and
disease
progression
monitoring
play
crucial
role
in
their
clinical
management.
The
common
diagnostic
prognostic
biomarkers
have
represented
revolutionary
tool
for
studying
CVD;
applications
limited
to
invasive
irreversible
heart
diseases,
such
drug-induced
myocardial
injury.
In
light
this
information,
growing
number
studies
currently
investigating
the
potential
novel
CVD
biomarkers.
Examples
long
non-coding
RNA
(lncRNA)
other
RNAs
that
specifically
expressed
at
stages
disease.
These
been
reported
be
involved
development
via
activating
or
inhibiting
inflammatory
mediators
angiogenesis-related
factors,
well
endothelial
cell
proliferation,
migration
phenotypic
transformation.
This
review
collectively
summarizes
recent
studies'
results
concerning
exosomal
lncRNA
biogenesis,
characterization,
function,
its
biomarker
variety
CVD.
Journal of Cellular and Molecular Medicine,
Год журнала:
2024,
Номер
28(24)
Опубликована: Дек. 1, 2024
ABSTRACT
Emerging
evidence
highlights
certain
long
noncoding
RNAs
(lncRNAs)
transcribed
from
or
interacting
with
super‐enhancer
(SE)
regulatory
elements.
These
lncRNAs,
known
as
SE‐lncRNAs,
are
strongly
linked
to
cancer
and
regulate
progression
through
multiple
interactions
downstream
targets.
The
expression
of
SE‐lncRNAs
is
controlled
by
various
transcription
factors
(TFs),
dysregulation
these
TFs
can
contribute
development.
In
this
review,
we
discuss
the
characteristics,
classification
subcellular
distribution
summarise
role
key
in
regulation
SE‐lncRNAs.
Moreover,
examine
distinct
functions
potential
mechanisms
progression.
