Advanced Healthcare Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 28, 2024
Abstract
Musculoskeletal
diseases
have
emerged
as
the
leading
cause
of
disability
worldwide,
with
their
prevalence
increasing
annually.
In
light
this
escalating
health
challenge,
organoids,
an
emerging
technology
in
tissue
engineering,
offer
promising
solutions
for
disease
modeling,
drug
screening,
regeneration,
and
repair
processes.
The
successful
development
musculoskeletal
organoids
represents
a
significant
breakthrough,
providing
novel
platform
studying
facilitating
discovery
new
treatments.
Moreover,
serve
valuable
complements
to
traditional
2D
culture
methods
animal
models,
offering
rich
insights
into
biology.
This
review
provides
overview
organoid
technology,
outlining
construction
processes
various
highlighting
similarities
differences.
Furthermore,
challenges
associated
systems
are
discussed
future
perspectives
offered.
Frontiers in Medicine,
Год журнала:
2025,
Номер
11
Опубликована: Янв. 24, 2025
The
liver
is
a
vital
organ
responsible
for
numerous
metabolic
processes
in
the
human
body,
including
metabolism
of
drugs
and
nutrients.
After
damage,
can
rapidly
return
to
its
original
size
if
causative
factor
promptly
eliminated.
However,
when
harmful
stimulus
persists,
liver’s
regenerative
capacity
becomes
compromised.
Substantial
theoretical
feasibility
has
been
demonstrated
at
levels
gene
expression,
molecular
interactions,
intercellular
dynamics,
complemented
by
successful
animal
studies.
robust
model
carrier
that
closely
resemble
physiology
are
still
lacking
translating
these
theories
into
practice.
potential
regeneration
central
focus
ongoing
research.
Over
past
decade,
advent
organoid
technology
provided
improved
models
materials
advancing
research
efforts.
Liver
represents
novel
vitro
culture
system.
several
years
refinement,
organoids
now
accurately
replicate
morphological
structure,
nutrient
drug
metabolism,
secretory
functions,
providing
disease
Regenerative
medicine
aims
or
tissue
functions
repair
replace
damaged
tissues,
restore
their
structure
function,
stimulate
tissues
organs
within
body.
possess
same
function
as
tissue,
offering
serve
viable
replacement
liver,
aligning
with
goals
medicine.
This
review
examines
role
Theranostics,
Год журнала:
2024,
Номер
15(2), С. 682 - 706
Опубликована: Дек. 2, 2024
Organoids,
self-organized
structures
derived
from
stem
cells
cultured
in
a
specific
three-dimensional
(3D)
vitro
microenvironment,
have
emerged
as
innovative
platforms
that
closely
mimic
vivo
cellular
behavior,
tissue
architecture,
and
organ
function.
Bone
organoids,
frontier
organoid
research,
can
replicate
the
complex
functional
characteristics
of
bone
tissue.
Recent
advancements
led
to
successful
development
including
models
callus,
woven
bone,
cartilage,
trabecular
marrow.
These
organoids
are
widely
utilized
establishing
bone-related
disease
models,
injury
repair,
drug
screening.
However,
significant
discrepancies
remain
between
current
human
skeletal
tissues
terms
morphology
functionality,
limiting
their
ability
accurately
model
physiology
pathology.
To
address
these
challenges
promote
standardization
construction,
evaluation,
application
we
convened
experts
research
teams
with
substantial
expertise
field.
By
integrating
existing
findings,
this
consortium
aims
establish
consensus
guide
future
organoids.
Materials Today Bio,
Год журнала:
2024,
Номер
28, С. 101167 - 101167
Опубликована: Авг. 3, 2024
In
confronting
the
global
prevalence
of
bone-related
disorders,
bone
tissue
engineering
(BTE)
has
developed
into
a
critical
discipline,
seeking
innovative
materials
to
revolutionize
treatment
paradigms.
Quantum
dots
(QDs),
nanoscale
semiconductor
particles
with
tunable
optical
properties,
are
at
cutting
edge
improving
regeneration.
This
comprehensive
review
delves
multifaceted
roles
that
QDs
play
within
realm
BTE,
emphasizing
their
potential
not
only
imaging
but
also
osteogenesis,
drug
delivery,
antimicrobial
strategies
and
phototherapy.
The
customizable
nature
QDs,
attributed
size-dependent
electronic
been
leveraged
develop
precise
modalities,
enabling
visualization
growth
scaffold
integration
an
unprecedented
resolution.
Their
nanoscopic
scale
facilitates
targeted
delivery
systems,
ensuring
localized
release
therapeutics.
possess
combat
infections
defect
sites,
preventing
bacterial
infections.
Additionally,
they
can
be
used
in
phototherapy
stimulate
important
repair
processes
work
well
immune
system
improve
overall
healing
environment.
combination
current
trendy
artificial
intelligence
(AI)
technology,
development
organoids
combined
QDs.
While
demonstrate
considerable
promise
transition
from
laboratory
research
clinical
application
is
fraught
challenges.
Concerns
regarding
biocompatibility,
long-term
stability
biological
environment,
cost-effectiveness
production
pose
significant
hurdles
adoption.
summarizes
BTE
highlights
challenges
lie
ahead.
By
overcoming
these
obstacles,
more
effective,
efficient,
personalized
regeneration
will
emerge,
offering
new
hope
for
patients
suffering
debilitating
diseases.
Frontiers in Oncology,
Год журнала:
2025,
Номер
15
Опубликована: Фев. 7, 2025
This
review
summarizes
the
applications
and
research
progress
of
organoid
models
in
colorectal
cancer
research.
First,
high
incidence
mortality
rates
are
introduced,
emphasizing
importance
organoids
as
a
model.
Second,
this
provides
detailed
introduction
to
concept,
biological
properties,
organoids,
including
their
strengths
mimicking
structural
functional
aspects
organs.
article
further
analyzes
adult
stem
cell-derived
pluripotent
discusses
advancements
for
basic
research,
drug
development,
personalized
treatment
evaluation
prediction,
regenerative
medicine.
Finally,
prospects
applying
technology
its
significant
value
improving
patient
survival
rates.
In
conclusion,
systematically
explains
highlighting
tremendous
potential
promising
Biomolecules,
Год журнала:
2024,
Номер
14(7), С. 794 - 794
Опубликована: Июль 4, 2024
Many
drug
and
therapeutic
modalities
have
emerged
over
the
past
few
years.
However,
successful
commercialization
is
dependent
on
their
safety
efficacy
evaluations.
Several
preclinical
models
are
available
for
drug-screening
evaluations,
including
cellular-
molecular-level
models,
tissue
organoid
animal
models.
Organoids
three-dimensional
cell
cultures
derived
from
primary
tissues
or
stem
cells
that
structurally
functionally
similar
to
original
organs
can
self-renew,
they
used
establish
various
disease
Human
hepatobiliary
organoids
been
study
pathogenesis
of
diseases,
such
as
hepatitis,
liver
fibrosis,
hepatocellular
carcinoma,
sclerosing
cholangitis
biliary
tract
cancer,
retain
physiological
histological
characteristics
bile
ducts.
Here,
we
review
recent
research
progress
in
validating
toxicity,
screening
personalized
therapy
hepatobiliary-related
diseases
using
human
discuss
challenges
encountered
current
evaluate
possible
solutions.
Journal of the National Cancer Center,
Год журнала:
2024,
Номер
4(3), С. 195 - 202
Опубликована: Июнь 17, 2024
Primary
liver
cancer
is
a
leading
cause
of
death
worldwide.
To
create
advanced
treatments
for
primary
cancer,
studies
have
utilized
models
such
as
2D
cell
culture
and
