The role of neutrophils in osteosarcoma: insights from laboratory to clinic DOI Creative Commons
Ming Xia, Yu Han,

Lihui Sun

и другие.

Frontiers in Immunology, Год журнала: 2024, Номер 15

Опубликована: Ноя. 8, 2024

Osteosarcoma, a highly aggressive malignant bone tumor, is significantly influenced by the intricate interactions within its tumor microenvironment (TME), particularly involving neutrophils. This review delineates multifaceted roles of neutrophils, including tumor-associated neutrophils (TANs) and neutrophil extracellular traps (NETs), in osteosarcoma’s pathogenesis. TANs exhibit both pro- anti-tumor phenotypes, modulating growth immune evasion, while NETs facilitate cell adhesion, migration, immunosuppression. Clinically, neutrophil-related markers such as neutrophil-to-lymphocyte ratio (NLR) predict patient outcomes, highlighting potential for neutrophil-targeted therapies. Unraveling these complex crucial developing novel treatment strategies that harness TME to improve osteosarcoma management.

Язык: Английский

Harnessing the tumor microenvironment: targeted cancer therapies through modulation of epithelial-mesenchymal transition DOI Creative Commons
Antonino Glaviano,

Hannah Lau,

Lukas M. Carter

и другие.

Journal of Hematology & Oncology, Год журнала: 2025, Номер 18(1)

Опубликована: Янв. 13, 2025

The tumor microenvironment (TME) is integral to cancer progression, impacting metastasis and treatment response. It consists of diverse cell types, extracellular matrix components, signaling molecules that interact promote growth therapeutic resistance. Elucidating the intricate interactions between cells TME crucial in understanding progression challenges. A critical process induced by epithelial-mesenchymal transition (EMT), wherein epithelial acquire mesenchymal traits, which enhance their motility invasiveness progression. By targeting various components TME, novel investigational strategies aim disrupt TME's contribution EMT, thereby improving efficacy, addressing resistance, offering a nuanced approach therapy. This review scrutinizes key players emphasizing avenues therapeutically components. Moreover, article discusses implications for resistance mechanisms highlights current toward modulation along with potential caveats.

Язык: Английский

Процитировано

26
Targeting neutrophils: Mechanism and advances in cancer therapy DOI Creative Commons
Shuaixi Yang,

Jiachi Jia,

Fuqi Wang

и другие.

Clinical and Translational Medicine, Год журнала: 2024, Номер 14(3)

Опубликована: Март 1, 2024

Abstract Background Cancer is a thorny problem which cannot be conquered by mankind at present and recent researchers have put their focus on tumor microenviroment. Neutrophils, the prominent leukocytes in peripheral blood that accumulate tumours, serves as frontline cells response to tumour progression owing rapid development of micro biotechnology. Hence, targeted therapy with these neutrophils has made targeting treatment promising field cancer therapy. Main body We broadly summarise some studies phenotypes functions tumour‐associated well unique web‐like products play role progression—neutrophil extracellular traps—and interactions between microenvironment. Moreover, several therapeutic progress provided potential strategies for cancer. Conclusion This review aims offer holistic perspective interventions further inspire more researches therapies.

Язык: Английский

Процитировано

17
Neutrophil extracellular traps in cancer DOI Creative Commons
Yuxi Ma, Jielin Wei, Wenshan He

и другие.

MedComm, Год журнала: 2024, Номер 5(8)

Опубликована: Июль 15, 2024

Neutrophil extracellular traps (NETs), which consist of chromatin DNA studded with granule proteins, are released by neutrophils in response to both infectious and sterile inflammation. Beyond the canonical role defense against pathogens, extrusion NETs also contributes initiation, metastasis, therapeutic malignant diseases. Recently, have been implicated development responses various types tumors. Although extensive work regarding inflammation tumors has reported, a comprehensive summary how these web-like structures initiate propagate tumor progression under specific microenvironment is lacking. In this review, we demonstrate initiators related signaling pathways that trigger formation cancers. Additionally, review will outline current molecular mechanisms regulatory networks during dormant cancer cells awakening, circulating (CTCs) extravasation, metastatic recurrence cancer. This followed perspective on potential clinical as targets treatment local disease, including improvement efficacy existing therapies.

Язык: Английский

Процитировано

13
Neutrophil diversity and function in health and disease DOI Creative Commons

F Zhang,

Yidan Xia,

Jiayang Su

и другие.

Signal Transduction and Targeted Therapy, Год журнала: 2024, Номер 9(1)

Опубликована: Дек. 5, 2024

Abstract Neutrophils, the most abundant type of granulocyte, are widely recognized as one pivotal contributors to acute inflammatory response. Initially, neutrophils were considered mobile infantry innate immune system, tasked with immediate response invading pathogens. However, recent studies have demonstrated that versatile cells, capable regulating various biological processes and impacting both human health disease. Cytokines other active mediators regulate functional activity by activating multiple receptors on these thereby initiating downstream signal transduction pathways. Dysfunctions in disruptions neutrophil homeostasis been implicated pathogenesis numerous diseases, including cancer disorders, often due aberrant intracellular signaling. This review provides a comprehensive synthesis functions, integrating advancements this field. Moreover, it examines roles signaling pathways involved regulation activity. The pathophysiology diseases emerging therapeutic approaches targeting them also elaborated. addresses current limitations within field research, highlighting critical gaps knowledge warrant further investigation. In summary, seeks establish multidimensional model regulation, providing new perspectives for potential clinical applications research.

Язык: Английский

Процитировано

11
Tumor-infiltrating myeloid cells; mechanisms, functional significance, and targeting in cancer therapy DOI Creative Commons
Fatemeh Sadat Toghraie, Maryam Bayat, Mahsa Sadat Hosseini

и другие.

Cellular Oncology, Год журнала: 2025, Номер unknown

Опубликована: Фев. 25, 2025

Tumor-infiltrating myeloid cells (TIMs), which encompass tumor-associated macrophages (TAMs), neutrophils (TANs), myeloid-derived suppressor (MDSCs), and dendritic (TADCs), are of great importance in tumor microenvironment (TME) integral to both pro- anti-tumor immunity. Nevertheless, the phenotypic heterogeneity functional plasticity TIMs have posed challenges fully understanding their complexity roles within TME. Emerging evidence suggested that presence is frequently linked prevention cancer treatment improvement patient outcomes survival. Given pivotal function TME, recently been recognized as critical targets for therapeutic approaches aimed at augmenting immunostimulatory cell populations while depleting or modifying those immunosuppressive. This review will explore important properties related immunity, angiogenesis, metastasis. We also document latest strategies targeting preclinical clinical settings. Our objective illustrate potential immunological may improve existing treatments.

Язык: Английский

Процитировано

1
Tumor Microenvironment: Cellular Interaction and Metabolic Adaptations DOI Open Access
Monica Benvenuto, Chiara Focaccetti

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(7), С. 3642 - 3642

Опубликована: Март 25, 2024

The tumor microenvironment (TME) plays a critical role in cancerogenesis [...]

Язык: Английский

Процитировано

4
FN1 Immunoregulation in Glioblastoma: Insights From Neutrophil‐Centric Studies DOI Creative Commons
Xiangtian Meng, Xiaoming Yang,

Junle Zhu

и другие.

Cancer Science, Год журнала: 2025, Номер unknown

Опубликована: Март 7, 2025

Neutrophils, as key components of the tumor microenvironment, play a crucial role in cancer progression and prognosis. This study aimed to identify neutrophil-related gene signature improve prognostic predictions explore potential immunotherapy targets for glioblastoma multiforme (GBM) patients. Through co-expression analysis, 60 neutrophil-associated genes were identified, showing significant enrichment 159 Gene Ontology terms eight KEGG pathways. Among these, 10 significantly associated with patient survival, leading development six-gene risk model termed Neutrophil-Related Prognostic Index (NRGPI). The NRGPI predicted overall survival (OS) both training validation cohorts (p < 0.05), enhanced accuracy when combined clinicopathological factors. Higher scores correlated worse OS, increased mortality, more aggressive disease progression. Immune profiling linked immune cell infiltration, checkpoint expression, mutation burden, suggesting its identifying candidates immunotherapy. identified genes, FN1 emerged central regulator, composition poor Pan-cancer analysis revealed consistent upregulation across types, underscoring broad clinical relevance. Additionally, tissue microarray using multiplex immunofluorescence on 84 GBM samples confirmed FN1, SDC1, TWIST1, higher levels reduced survival. These findings establish valuable biomarker GBM, offering novel insights into landscape positioning promising therapeutic target further investigation treatment.

Язык: Английский

Процитировано

0
Decoding STING’s roles in cancer: immunity, pain, dormancy, and autophagy DOI
Huan‐Xin Lin, Ya‐ling Tang,

Xinhua Liang

и другие.

Molecular and Cellular Biochemistry, Год журнала: 2025, Номер unknown

Опубликована: Апрель 24, 2025

Язык: Английский

Процитировано

0
Targeting the Senescent Tumor Microenvironment to Sensitize Immunotherapy DOI
Wen Sun

Highlights in Science Engineering and Technology, Год журнала: 2025, Номер 139, С. 260 - 271

Опубликована: Апрель 28, 2025

The tumor microenvironment (TME) plays a pivotal role in cancer progression, metastasis, and therapeutic resistance. Cellular senescence within the TME, characterized by irreversible growth arrest senescence-associated secretory phenotype (SASP), profoundly impacts biology immunotherapy efficacy. senescent TME promotes growth, invasion, metastasis through complex interactions between cells, SASP factors, extracellular matrix (ECM). Simultaneously, senescence-induced alterations immune cell function, including T exhaustion, macrophage polarization, impaired natural killer (NK) cytotoxicity, contribute to an immunosuppressive niche that hinders immunosurveillance fosters evasion. Mounting evidence suggests is critical mediator of resistance checkpoint inhibitors (ICIs). Senescence-associated changes dampen antitumor immunity reducing CD8+ infiltration functionality while promoting accumulation populations such as regulatory cells (Tregs) myeloid-derived suppressor (MDSCs). Consequently, strategies targeting have emerged promising approaches enhance ICI Senolytic agents, inhibitors, combinatorial therapies aimed at eliminating modulating SASP, reprogramming shown potential preclinical models sensitize tumors immunotherapy. As our understanding evolves, it becoming increasingly clear multifaceted approach integrating TME-targeted interventions with necessary overcome improve patient outcomes. Future research should focus on elucidating molecular mechanisms underlying senescence-driven resistance, identifying robust biomarkers predict treatment response, developing novel synergize ICIs. By harnessing approaches, we can expand scope efficacy immunotherapy, ultimately leading improved survival quality life for patients.

Язык: Английский

Процитировано

0
Unraveling the complex role of tumor-associated neutrophils within solid tumors DOI Creative Commons
Yingxin Wang, Jiakang Ma, Yuhao Liu

и другие.

Cancer Immunology Immunotherapy, Год журнала: 2025, Номер 74(7)

Опубликована: Май 19, 2025

Abstract Neutrophils are integral to the frontline defense against pathogenic bacterial and fungal invasions. Beyond their traditional roles, these cells increasingly recognized for dualistic contributions pathology of autoimmune inflammatory diseases, as well complex involvement in cancer progression. interact with different disease states, highlighting potential therapeutic targets. Within tumor microenvironment (TME), tumor-associated neutrophils (TANs) exhibit a functional dichotomy, capable either fostering or impeding growth metastasis. This binary TANs, under certain conditions, suggests reversible state that could transition from tumor-promoting tumor-eradicating phenotypes. Despite critical implications such plasticity, systematic studies TAN behavioral shifts context immunotherapy remain scarce. Herein, we review recent advancements understanding TANs within TME, regulatory effects on solid tumors. Leveraging latest insights experimental clinical research, this elucidates roles development explores molecular interactions The elucidation mechanisms holds promise novel treatment strategies, aiming improve patient outcomes by manipulating -suppressing functions TANs.

Язык: Английский

Процитировано

0