Frontiers in Immunology,
Год журнала:
2024,
Номер
15
Опубликована: Ноя. 8, 2024
Osteosarcoma,
a
highly
aggressive
malignant
bone
tumor,
is
significantly
influenced
by
the
intricate
interactions
within
its
tumor
microenvironment
(TME),
particularly
involving
neutrophils.
This
review
delineates
multifaceted
roles
of
neutrophils,
including
tumor-associated
neutrophils
(TANs)
and
neutrophil
extracellular
traps
(NETs),
in
osteosarcoma’s
pathogenesis.
TANs
exhibit
both
pro-
anti-tumor
phenotypes,
modulating
growth
immune
evasion,
while
NETs
facilitate
cell
adhesion,
migration,
immunosuppression.
Clinically,
neutrophil-related
markers
such
as
neutrophil-to-lymphocyte
ratio
(NLR)
predict
patient
outcomes,
highlighting
potential
for
neutrophil-targeted
therapies.
Unraveling
these
complex
crucial
developing
novel
treatment
strategies
that
harness
TME
to
improve
osteosarcoma
management.
Journal of Hematology & Oncology,
Год журнала:
2025,
Номер
18(1)
Опубликована: Янв. 13, 2025
The
tumor
microenvironment
(TME)
is
integral
to
cancer
progression,
impacting
metastasis
and
treatment
response.
It
consists
of
diverse
cell
types,
extracellular
matrix
components,
signaling
molecules
that
interact
promote
growth
therapeutic
resistance.
Elucidating
the
intricate
interactions
between
cells
TME
crucial
in
understanding
progression
challenges.
A
critical
process
induced
by
epithelial-mesenchymal
transition
(EMT),
wherein
epithelial
acquire
mesenchymal
traits,
which
enhance
their
motility
invasiveness
progression.
By
targeting
various
components
TME,
novel
investigational
strategies
aim
disrupt
TME's
contribution
EMT,
thereby
improving
efficacy,
addressing
resistance,
offering
a
nuanced
approach
therapy.
This
review
scrutinizes
key
players
emphasizing
avenues
therapeutically
components.
Moreover,
article
discusses
implications
for
resistance
mechanisms
highlights
current
toward
modulation
along
with
potential
caveats.
Clinical and Translational Medicine,
Год журнала:
2024,
Номер
14(3)
Опубликована: Март 1, 2024
Abstract
Background
Cancer
is
a
thorny
problem
which
cannot
be
conquered
by
mankind
at
present
and
recent
researchers
have
put
their
focus
on
tumor
microenviroment.
Neutrophils,
the
prominent
leukocytes
in
peripheral
blood
that
accumulate
tumours,
serves
as
frontline
cells
response
to
tumour
progression
owing
rapid
development
of
micro
biotechnology.
Hence,
targeted
therapy
with
these
neutrophils
has
made
targeting
treatment
promising
field
cancer
therapy.
Main
body
We
broadly
summarise
some
studies
phenotypes
functions
tumour‐associated
well
unique
web‐like
products
play
role
progression—neutrophil
extracellular
traps—and
interactions
between
microenvironment.
Moreover,
several
therapeutic
progress
provided
potential
strategies
for
cancer.
Conclusion
This
review
aims
offer
holistic
perspective
interventions
further
inspire
more
researches
therapies.
Neutrophil
extracellular
traps
(NETs),
which
consist
of
chromatin
DNA
studded
with
granule
proteins,
are
released
by
neutrophils
in
response
to
both
infectious
and
sterile
inflammation.
Beyond
the
canonical
role
defense
against
pathogens,
extrusion
NETs
also
contributes
initiation,
metastasis,
therapeutic
malignant
diseases.
Recently,
have
been
implicated
development
responses
various
types
tumors.
Although
extensive
work
regarding
inflammation
tumors
has
reported,
a
comprehensive
summary
how
these
web-like
structures
initiate
propagate
tumor
progression
under
specific
microenvironment
is
lacking.
In
this
review,
we
demonstrate
initiators
related
signaling
pathways
that
trigger
formation
cancers.
Additionally,
review
will
outline
current
molecular
mechanisms
regulatory
networks
during
dormant
cancer
cells
awakening,
circulating
(CTCs)
extravasation,
metastatic
recurrence
cancer.
This
followed
perspective
on
potential
clinical
as
targets
treatment
local
disease,
including
improvement
efficacy
existing
therapies.
Signal Transduction and Targeted Therapy,
Год журнала:
2024,
Номер
9(1)
Опубликована: Дек. 5, 2024
Abstract
Neutrophils,
the
most
abundant
type
of
granulocyte,
are
widely
recognized
as
one
pivotal
contributors
to
acute
inflammatory
response.
Initially,
neutrophils
were
considered
mobile
infantry
innate
immune
system,
tasked
with
immediate
response
invading
pathogens.
However,
recent
studies
have
demonstrated
that
versatile
cells,
capable
regulating
various
biological
processes
and
impacting
both
human
health
disease.
Cytokines
other
active
mediators
regulate
functional
activity
by
activating
multiple
receptors
on
these
thereby
initiating
downstream
signal
transduction
pathways.
Dysfunctions
in
disruptions
neutrophil
homeostasis
been
implicated
pathogenesis
numerous
diseases,
including
cancer
disorders,
often
due
aberrant
intracellular
signaling.
This
review
provides
a
comprehensive
synthesis
functions,
integrating
advancements
this
field.
Moreover,
it
examines
roles
signaling
pathways
involved
regulation
activity.
The
pathophysiology
diseases
emerging
therapeutic
approaches
targeting
them
also
elaborated.
addresses
current
limitations
within
field
research,
highlighting
critical
gaps
knowledge
warrant
further
investigation.
In
summary,
seeks
establish
multidimensional
model
regulation,
providing
new
perspectives
for
potential
clinical
applications
research.
Cellular Oncology,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 25, 2025
Tumor-infiltrating
myeloid
cells
(TIMs),
which
encompass
tumor-associated
macrophages
(TAMs),
neutrophils
(TANs),
myeloid-derived
suppressor
(MDSCs),
and
dendritic
(TADCs),
are
of
great
importance
in
tumor
microenvironment
(TME)
integral
to
both
pro-
anti-tumor
immunity.
Nevertheless,
the
phenotypic
heterogeneity
functional
plasticity
TIMs
have
posed
challenges
fully
understanding
their
complexity
roles
within
TME.
Emerging
evidence
suggested
that
presence
is
frequently
linked
prevention
cancer
treatment
improvement
patient
outcomes
survival.
Given
pivotal
function
TME,
recently
been
recognized
as
critical
targets
for
therapeutic
approaches
aimed
at
augmenting
immunostimulatory
cell
populations
while
depleting
or
modifying
those
immunosuppressive.
This
review
will
explore
important
properties
related
immunity,
angiogenesis,
metastasis.
We
also
document
latest
strategies
targeting
preclinical
clinical
settings.
Our
objective
illustrate
potential
immunological
may
improve
existing
treatments.
Cancer Immunology Immunotherapy,
Год журнала:
2025,
Номер
74(7)
Опубликована: Май 19, 2025
Abstract
Neutrophils
are
integral
to
the
frontline
defense
against
pathogenic
bacterial
and
fungal
invasions.
Beyond
their
traditional
roles,
these
cells
increasingly
recognized
for
dualistic
contributions
pathology
of
autoimmune
inflammatory
diseases,
as
well
complex
involvement
in
cancer
progression.
interact
with
different
disease
states,
highlighting
potential
therapeutic
targets.
Within
tumor
microenvironment
(TME),
tumor-associated
neutrophils
(TANs)
exhibit
a
functional
dichotomy,
capable
either
fostering
or
impeding
growth
metastasis.
This
binary
TANs,
under
certain
conditions,
suggests
reversible
state
that
could
transition
from
tumor-promoting
tumor-eradicating
phenotypes.
Despite
critical
implications
such
plasticity,
systematic
studies
TAN
behavioral
shifts
context
immunotherapy
remain
scarce.
Herein,
we
review
recent
advancements
understanding
TANs
within
TME,
regulatory
effects
on
solid
tumors.
Leveraging
latest
insights
experimental
clinical
research,
this
elucidates
roles
development
explores
molecular
interactions
The
elucidation
mechanisms
holds
promise
novel
treatment
strategies,
aiming
improve
patient
outcomes
by
manipulating
-suppressing
functions
TANs.