Cell Death and Disease,
Год журнала:
2024,
Номер
15(12)
Опубликована: Дек. 18, 2024
Abstract
Acute
kidney
injury
(AKI)
is
a
significant
global
health
issue,
which
often
caused
by
cisplatin
therapy
and
characterized
mitochondrial
dysfunction.
Restoring
homeostasis
in
tubular
cells
could
exert
therapeutic
effects.
Here,
we
investigated
Slc25a21,
carrier,
as
potential
target
for
AKI
intervention.
Renal
Slc25a21
expression
negatively
associated
with
function
both
patients
cisplatin-induced
murine
models.
Sustaining
renal
of
slowed
down
progression
reducing
cellular
apoptosis,
necroptosis,
the
inflammatory
response,
likely
through
its
regulation
2-oxoadipate
conversion.
highly
expressed
proximal
epithelial
cells,
down-regulation
contributes
to
compromised
biogenesis
integrity,
well
impaired
oxidative
phosphorylation.
Mechanistically,
reduced
disrupts
transport,
affecting
related
metabolites
influx
tricarboxylic
acid
cycle.
These
findings
demonstrate
previously
unappreciated
metabolic
suggest
that
targeting
sustaining
be
novel
strategy
AKI.
Cancer Cell International,
Год журнала:
2024,
Номер
24(1)
Опубликована: Янв. 18, 2024
Abstract
One
of
the
key
features
cancer
is
energy
metabolic
reprogramming
which
tightly
related
to
proliferation,
invasion,
metastasis,
and
chemotherapy
resistance.
NcRNAs
are
a
class
RNAs
having
no
protein-coding
potential
mainly
include
microRNAs,
lncRNAs
circRNAs.
Accumulated
evidence
has
suggested
that
ncRNAs
play
an
essential
role
in
regulating
reprogramming,
altered
networks
mediated
by
primarily
drive
carcinogenesis
expression
enzymes
transporter
proteins.
Importantly,
accumulated
research
revealed
dysregulated
mediate
contributing
generation
therapeutic
tolerance.
Elucidating
molecular
mechanism
can
provide
promising
metabolism-related
targets
for
treatment
as
well
overcome
In
conclusion,
this
review
updates
latest
mechanisms
reprogramming.
The
global
prevalence
of
obesity
has
reached
epidemic
levels,
significantly
elevating
the
susceptibility
to
various
cardiometabolic
conditions
and
certain
types
cancer.
In
addition
causing
metabolic
abnormalities
such
as
insulin
resistance
(IR),
elevated
blood
glucose
lipids,
ectopic
fat
deposition,
can
also
damage
pancreatic
islet
cells,
endothelial
cardiomyocytes
through
chronic
inflammation,
even
promote
development
a
microenvironment
conducive
cancer
initiation.
Improper
dietary
habits
lack
physical
exercise
are
important
behavioral
factors
that
increase
risk
obesity,
which
affect
gene
expression
epigenetic
modifications.
Epigenetic
alterations
occur
in
early
stage
some
reversible,
while
others
persist
over
time
lead
obesity-related
complications.
Therefore,
dynamic
adjustability
modifications
be
leveraged
reverse
obesity-associated
diseases
interventions,
drugs,
bariatric
surgery.
This
review
provides
comprehensive
summary
impact
regulation
on
initiation
cancers,
type
2
diabetes,
cardiovascular
diseases,
establishing
theoretical
basis
for
prevention,
diagnosis,
treatment
these
conditions.
Molecular Carcinogenesis,
Год журнала:
2024,
Номер
63(10), С. 1922 - 1937
Опубликована: Июнь 27, 2024
Cancer-associated
fibroblasts
(CAFs)
are
abundant
and
heterogeneous
stromal
cells
in
the
tumor
microenvironment,
which
play
important
roles
regulating
progression
therapy
resistance
by
transferring
exosomes
to
cancer
cells.
However,
how
CAFs
modulate
esophageal
squamous
cell
carcinoma
(ESCC)
radioresistance
remains
incompletely
understood.
The
expression
of
fibroblast
activation
protein
(FAP)
was
evaluated
immunohistochemistry
174
ESCC
patients
who
underwent
surgery
78
pretreatment
biopsy
specimens
definitive
chemoradiotherapy.
We
sorted
according
FAP
expression,
conditioned
medium
(CM)
collected
culture
levels
several
lncRNAs
that
were
considered
regulate
and/or
measured
derived
from
Clinical and Translational Medicine,
Год журнала:
2022,
Номер
12(6)
Опубликована: Июнь 1, 2022
Obesity
alters
metabolic
microenvironment
and
is
thus
associated
with
several
tumours.
The
aim
of
the
present
study
was
to
investigate
role,
molecular
mechanism
action,
potential
clinical
value
lipid
metabolism-related
long
non-coding
RNA
(lncRNA)
SLC25A21-AS1
in
oesophageal
squamous
cell
carcinoma
(ESCC).A
high-fat
diets
(HFDs)-induced
obesity
nude
mouse
model
established,
targeted
metabolomics
analysis
used
identify
critical
medium-long
chain
fatty
acids
influencing
growth
ESCC
cells.
Transcriptomic
public
dataset
GSE53625
confirmed
that
lncRNA
a
lncRNA.
biological
function
investigated
both
vivo
vitro.
Chromatin
immunoprecipitation(ChIP)assay,
RNA-pull
down,
mass
spectrometry,
co-IP,
IP(RIP)
were
performed
explore
mechanism.
Finally,
an
cDNA
microarray
determine
prognostic
by
RT-qPCR.Palmitic
acid
(PA)
important
component
HFD
had
inhibitory
effect
on
lines.
LncRNA
expression
downregulated
PA
proliferation
migration
cells
vitro
vivo.
Mechanistically,
interacted
nucleophosmin-1
(NPM1)
protein
promote
downstream
gene
transcription
c-Myc
nucleus.
In
cytoplasm,
maintained
stability
SLC25A21
mRNA
reduced
intracellular
NAD+
/NADH
ratio
tryptophan
catabolism.
we
demonstrated
high
promoted
resistance
cisplatin-induced
apoptosis
correlated
poor
tumour
grade
overall
survival.HFD/PA
has
expression.
promotes
regulating
NPM1/c-Myc
axis
addition,
may
serve
as
favourable
biomarker
therapeutic
target
for
ESCC.
Cell Reports,
Год журнала:
2025,
Номер
44(2), С. 115324 - 115324
Опубликована: Фев. 1, 2025
Hematopoietic
stem
and
progenitor
cells
(HSPCs)
undergo
rapid
transcriptional
transitions
among
distinct
cell
states
functional
properties
during
development,
but
the
underlying
molecular
mechanism
is
largely
unknown.
Here,
we
characterize
mRNA
m5C
landscape
of
developing
HSPCs
in
zebrafish
found
that
modification
essential
for
HSPC
expansion
through
maintaining
stability.
Deletion
reader,
Y-box
binding
protein
1
(Ybx1),
significantly
inhibits
proliferation
mice.
Mechanistically,
Ybx1
recognizes
m5C-modified
mRNAs
maintains
stability
cell-cycle-related
transcripts,
thereby
ensuring
proper
expansion.
This
study
reveals
critical
role
Ybx1-mediated
developmental
hematopoiesis
provides
new
insights
epitransciptomic
strategies
optimizing
Advanced Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 5, 2025
Extensive
fibrous
stroma
plays
an
important
role
in
gemcitabine
(GEM)
resistance.
However,
the
mechanism
by
which
pancreatic
cancer
cells
interact
with
stellate
(PSCs)
to
promote
GEM
resistance
remains
unclear.
This
study
investigates
of
metabolic
crosstalk
between
these
two
inducing
Extracellular
vesicles
(EVs)
parental
and
GEM-resistant
are
extracted
performed
assays
long
noncoding
RNA
(lncRNA)
sequencing.
Pancreatic
cell-derived
EVs
PSCs
activation
extracellular
matrix
formation,
produce
more
asparagine
(Asn),
favoring
activation.
Mechanistically,
mediate
linc-ZNF25-1
Asn
uptake
via
IGF2BP3/c-Myc/SLC1A5
pathway
PSCs.
In
addition,
mouse
models
elucidate
oncogenic
function
enhanced
therapeutic
effect
asparaginase
(L-ASNase)
combination
cancer.
demonstrates
that
released
from
through
upregulation
SLC1A5
PSCs,
facilitating
GEM.
L-ASNase
is
a
potential
strategy
for
targeting
stromal
enhance
efficacy
chemotherapeutic
agents
against
Frontiers in Endocrinology,
Год журнала:
2024,
Номер
15
Опубликована: Сен. 13, 2024
This
paper
explores
the
significant
role
of
epigenetics
in
women's
reproductive
health,
focusing
on
impact
environmental
factors.
It
highlights
crucial
link
between
epigenetic
modifications-such
as
DNA
methylation
and
histones
post-translational
modifications-and
health
issues,
including
infertility
pregnancy
complications.
The
reviews
influence
pollutants
like
PM2.5,
heavy
metals,
endocrine
disruptors
gene
expression
through
mechanisms,
emphasizing
need
for
understanding
how
dietary,
lifestyle
choices,
exposure
to
chemicals
affect
health.
Future
research
directions
include
deeper
investigation
into
female
leveraging
editing
mitigate
changes
improving
IVF
success
rates
managing
disorders.
