Major depressive disorder

Nature Reviews Disease Primers, Год журнала: 2023, Номер 9(1)

Опубликована: Авг. 24, 2023

Язык: Английский

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The clinical characterization of the adult patient with bipolar disorder aimed at personalization of management

World Psychiatry, Год журнала: 2022, Номер 21(3), С. 364 - 387

Опубликована: Сен. 8, 2022

Bipolar disorder is heterogeneous in phenomenology, illness trajectory, and response to treatment. Despite evidence for the efficacy of multimodal-ity interventions, majority persons affected by this do not achieve sustain full syndromal recovery. It eagerly anticipated that combining datasets across various information sources (e.g., hierarchical "multi-omic" measures, electronic health records), analyzed using advanced computational methods machine learning), will inform future diagnosis treatment selection. In interim, identifying clinically meaningful subgroups with having differential specific treatments at point-of-care an empirical priority. This paper endeavours synthesize salient domains clinical characterization adult patient bipolar disorder, overarching aim improve outcomes informing management considerations. Extant data indicate characterizing select provides actionable guides shared decision making. For example, it robustly established presence mixed features - especially during depressive episodes physical psychiatric comorbidities informs treatment, suicide risk. addition, early environmental exposures sexual abuse, emotional neglect) are highly associated more complicated presentations, inviting need developmentally-oriented integrated approaches. There have been significant advances validating subtypes I vs. II disorder), particularly regard pharmacological interventions. As other severe mental disorders, social functioning, interpersonal/family relationships internalized stigma relevant relapse risk, outcomes, quality life. The elevated standardized mortality ratio completed suicidal behaviour invites domain all patients. framework describe above domains, providing a synthesis extant literature recommendations support tools metrics can be implemented point-of-care.

Язык: Английский

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Depression, anxiety, and insomnia symptoms among Chinese college students: A network analysis across pandemic stages

Journal of Affective Disorders, Год журнала: 2024, Номер 356, С. 54 - 63

Опубликована: Апрель 6, 2024

Язык: Английский

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The Effects of Intermittent Fasting on Brain and Cognitive Function

Nutrients, Год журнала: 2021, Номер 13(9), С. 3166 - 3166

Опубликована: Сен. 10, 2021

The importance of diet and the gut-brain axis for brain health cognitive function is increasingly acknowledged. Dietary interventions are tested their potential to prevent and/or treat disorders. Intermittent fasting (IF), abstinence or strong limitation calories 12 48 h, alternated with periods regular food intake, has shown promising results on neurobiological in animal models. In this review article, we discuss benefits IF possible effects prevention progress brain-related disorders animals humans. We do so by summarizing which through metabolic, cellular, circadian mechanisms lead anatomical functional changes brain. Our shows that there no clear evidence a positive short-term effect cognition healthy subjects. Clinical studies show epilepsy, Alzheimer's disease, multiple sclerosis disease symptoms progress. Findings from Parkinson's ischemic stroke, autism spectrum disorder, mood anxiety could benefit IF. Future research should disentangle whether hold true regardless age presence obesity. Moreover, variations patterns, total caloric intake specific nutrients may be relevant components success. Longitudinal randomized clinical trials (RCTs) will provide window into long-term development diseases.

Язык: Английский

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Cross-cultural validation and measurement invariance of anxiety and depression symptoms: A study of the Brief Symptom Inventory (BSI) in 42 countries

Journal of Affective Disorders, Год журнала: 2024, Номер 350, С. 991 - 1006

Опубликована: Янв. 18, 2024

Язык: Английский

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Temporal Dynamics Between Depression and Anxiety Symptoms During Internet-Based Therapy and in the General Population

Clinical Psychological Science, Год журнала: 2025, Номер unknown

Опубликована: Янв. 30, 2025

Symptoms of depression and anxiety frequently co-occur, but traditional discrete-time models fail to capture their causal interactions. To explore the dynamic relationship between these symptoms, we applied two advanced methodologies—non-Gaussian direction dependence analyses continuous-time structural equation modeling—across therapist-guided internet-based cognitive-behavioral therapy (iCBT) samples general-population cohorts ( N = 22,530). Our findings revealed that in iCBT, neither nor exhibited dominance; instead, changes were driven by shared transdiagnostic processes. In general population, showed unidirectional dominance over anxiety; stable symptom levels sustained time-invariant factors multiple years. Overall, this large-scale study suggests interplay is primarily processes alongside primacy depression. These insights underscore importance non-Gaussian modeling understanding mental-health comorbidities advocate for practices treating both anxiety.

Язык: Английский

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Preoperative psychological distress and acute postoperative pain among abdominal surgery patients

Journal of Psychosomatic Research, Год журнала: 2025, Номер 190, С. 112055 - 112055

Опубликована: Фев. 10, 2025

Язык: Английский

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Dropout from exercise randomized controlled trials among people with anxiety and stress-related disorders: A meta-analysis and meta-regression

Journal of Affective Disorders, Год журнала: 2021, Номер 282, С. 996 - 1004

Опубликована: Янв. 8, 2021

Язык: Английский

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When Anxiety and Depression Coexist: The Role of Differential Diagnosis Using Clinimetric Criteria

Psychotherapy and Psychosomatics, Год журнала: 2021, Номер 90(5), С. 308 - 317

Опубликована: Янв. 1, 2021

Depressive and anxiety disorders are frequently associated. Depression may be a complication of can complicate depression. The nature their relationship has been source controversy. Reviews generally base conclusions on randomized controlled trials meta-analyses that refer to the average patient often clash with variety clinical presentations occur when depression coexist. aim this review was examine literature according profiling subgroups patients based clinimetric criteria, in line recently developed concept medicine-based evidence. We critically reviewed pertaining specific depression, outlining advantages disadvantages each treatment approach. following prototypic cases were presented: secondary an active disorder, under treatment, anxious as residual component demoralization disorder. argue selection coexist should take into account modalities presentation filtered by judgment. Very different indications ensue is examined perspective.

Язык: Английский

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Effectiveness of Schema Therapy versus Cognitive Behavioral Therapy versus Supportive Therapy for Depression in Inpatient and Day Clinic Settings: A Randomized Clinical Trial

Psychotherapy and Psychosomatics, Год журнала: 2024, Номер 93(1), С. 24 - 35

Опубликована: Янв. 1, 2024

<b><i>Introduction:</i></b> Schema therapy (ST) reduces depressive symptoms, but clinical trials have not investigated its effectiveness for patients suffering from severe forms of depression and high rates comorbidities. There is demand exploring improving treatments this patient group. The objective the current study was to evaluate whether ST more effective than individual supportive (IST) noninferior compared with cognitive behavioral (CBT) in treating depression. <b><i>Methods:</i></b> For trial, medicated were recruited inpatient day clinic settings. major inclusion criteria age between 18 75 years primary diagnosis without psychotic symptoms. A total 292 participants randomized ST, CBT, or IST received 7 weeks psychotherapy (up 14 group sessions). outcome change severity after treatment measured by Beck Depression Inventory-II. Primary test efficacy superiority over IST. Secondary noninferiority CBT. Multilevel modeling conducted. results at 6-month follow-up explored. <b><i>Results:</i></b> Across treatment, superior analyses completer showed similar results. However, clinically relevant <b><i>Conclusion:</i></b> as part a psychiatric care program being represents potentially useful addition therapeutic repertoire efficacy, including long-term should be evaluated further.

Язык: Английский

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