Lung
cancer
remains
a
major
global
health
challenge
and
one
of
the
leading
causes
cancer-related
deaths
worldwide.
Despite
significant
advancements
in
treatment,
challenges
such
as
drug
resistance,
side
effects,
metastasis
recurrence
continue
to
impact
patient
outcomes
quality
life.
In
response,
there
is
growing
interest
complementary
integrative
approaches
care.
Traditional
Chinese
medicine
(TCM),
with
its
long
history,
abundant
clinical
experience,
holistic
perspective
individualized
approach,
has
garnered
increasing
attention
for
role
lung
prevention
management.
This
review
provides
comprehensive
overview
advances
TCM
covering
theoretical
foundation,
treatment
principles,
experiences
evidence
supporting
efficacy.
We
also
provide
systematic
summary
preclinical
mechanisms,
through
which
impacts
cancer,
including
induction
cell
death,
reversal
inhibition
modulation
immune
responses.
Additionally,
future
prospects
are
discussed,
offering
insights
into
expanded
application
integration
modern
address
this
challenging
disease.
Heliyon,
Год журнала:
2023,
Номер
9(12), С. e22734 - e22734
Опубликована: Ноя. 23, 2023
The
correlation
between
FOXM1
and
KIF20A
has
not
been
revealed
in
clear
cell
renal
carcinoma
(ccRCC).Public
data
was
downloaded
from
Cancer
Genome
Atlas
(TCGA)
database.
R
software
utilized
for
the
execution
of
bioinformatic
analysis.
expression
levels
specific
molecules
(mRNA
protein)
were
detected
using
real-time
quantitative
PCR
(qRT-PCR)
Western
blot
assays.
capacity
growth
assessed
by
employing
CCK8
colony
formation
assay.
Cell
invasion
migration
ability
transwell
assay.In
our
study,
we
illustrated
association
KIF20A.
Our
results
indicated
that
both
associated
with
poor
prognosis
clinical
performance.
malignant
characteristics
ccRCC
cells
can
be
significantly
suppressed
inhibiting
KIF20A,
as
demonstrated
vitro
experiments.
Moreover,
found
upregulate
Then,
EMT
signaling
identified
underlying
pathway
are
involved.
WB
FOXM1/KIF20A
axis
activate
signaling.
noticed
affect
immunotherapy
response
immune
microenvironment
patients.Our
role
progression
immunotherapy,
making
it
target
ccRCC.
ACS Biomaterials Science & Engineering,
Год журнала:
2024,
Номер
10(7), С. 4347 - 4358
Опубликована: Июнь 6, 2024
In
order
to
improve
the
effectiveness
of
tumor
treatment
and
reduce
toxic
side
effects
drugs,
we
formed
carrier-free
multifunctional
nanoparticles
(BI
NPs)
by
noncovalent
interaction
berberine
hydrochloride
IR780.
BI
NPs
possessed
synergistic
promoting
apoptosis,
inhibiting
proliferation
metastasis
tumors,
phototherapeutic
treatment.
Dispersive
passive
targeting
ability
retention
(EPR)
on
sites
in
vivo
could
be
monitored
fluorescence
imaging.
addition,
exhibited
effective
reactive
oxygen
species
(ROS)
generation
photothermal
conversion
capabilities,
photodynamic
therapy
(PDT),
(PTT).
Importantly,
inhibit
suppression
through
AMPK/PI3K/AKT
signaling
pathway
metastasis.
not
only
have
efficient
multimodal
therapeutic
but
also
good
biosafety
potential
clinical
applications.
Cancers,
Год журнала:
2025,
Номер
17(4), С. 685 - 685
Опубликована: Фев. 18, 2025
New
therapeutic
approaches
that
antagonize
tumour-promoting
phenotypes
in
lung
cancer
are
needed
to
improve
patient
outcomes.
Chromosomal
instability
(CIN)
is
a
hallmark
of
characterized
by
the
ongoing
acquisition
genetic
alterations
include
gain
and
loss
whole
chromosomes
or
segments
as
well
chromosomal
rearrangements
during
cell
division.
Although
it
provides
diversity
fuels
tumour
evolution
enables
aggressive
like
immune
evasion,
metastasis,
drug
resistance,
too
much
CIN
can
be
lethal
because
creates
imbalances
disrupt
essential
genes
induce
severe
proteotoxic
metabolic
stress.
As
such,
sustaining
advantageous
levels
compatible
with
survival
fine
balance
cells,
potentiating
exceed
tolerable
threshold
promising
treatment
strategy
for
inherently
unstable
tumours
cancer.
Kinesins
superfamily
motor
proteins
many
members
having
functions
mitosis
critical
correct
segregation
and,
consequently,
maintaining
genomic
integrity.
Accordingly,
inhibition
such
kinesins
has
been
shown
exacerbate
CIN.
Therefore,
inhibiting
mitotic
represents
amplifying
vulnerable
cells.
In
this
review,
we
describe
concept
vulnerability
comprehensively
summarize
studies
reporting
clinical
functional
relevance
cancer,
goal
outlining
how
kinesin
inhibition,
"targeting
kinesins",
holds
great
potential
an
effective
treating
Pharmacological Research,
Год журнала:
2025,
Номер
unknown, С. 107742 - 107742
Опубликована: Апрель 1, 2025
Cancer
continues
to
be
among
the
most
substantial
health
challenges
globally.
Among
various
natural
compounds,
berberine,
an
isoquinoline
alkaloid
obtained
from
Coptidis
Rhizoma,
has
garnered
considerable
attention
for
its
broad-spectrum
biological
activities,
including
anti-inflammatory,
antioxidant,
anti-diabetic,
anti-obesity,
and
anti-microbial
activities.
Furthermore,
berberine
exhibits
a
broad
spectrum
of
anti-cancer
efficacy
against
malignancies,
such
as
ovarian,
breast,
lung,
gastric,
hepatic,
colorectal,
cervical,
prostate
cancers.
Its
mechanisms
are
multifaceted,
encompassing
inhibition
cancer
cell
proliferation,
prevention
metastasis,
induction
apoptosis,
facilitation
autophagy,
modulation
tumor
microenvironment
gut
microbiota,
enhancement
conventional
therapeutic
strategies.
This
paper
offers
exhaustive
overview
cancer-fighting
characteristics
Rhizoma
while
also
exploring
recent
developments
in
nanotechnology
aimed
at
enhancing
bioavailability
berberine.
side
effects
safety
addressed
well.
The
potential
role
artificial
intelligence
optimizing
berberine's
applications
is
highlighted.
provides
precious
perspectives
on
prospective
application
management
cancer.
Journal of Biochemical and Molecular Toxicology,
Год журнала:
2024,
Номер
39(1)
Опубликована: Дек. 24, 2024
ABSTRACT
Berberine,
an
isoquinoline
alkaloid
derived
from
various
medicinal
plants,
emerges
as
a
potential
therapeutic
agent
against
diverse
human
diseases.
It
has
particularly
shown
notable
anticancer
efficacy
breast,
colorectal,
lung,
prostate,
and
liver
cancer.
Berberine
results
in
inhibition
of
cancer
cell
proliferation,
induction
apoptosis,
suppressing
angiogenesis,
positioning
it
versatile,
multitargeted
tool
Notably,
berberine
enhances
the
effectiveness
conventional
chemotherapeutic
drugs,
mitigating
associated
drug
resistance.
Mechanistically,
been
to
exert
its
by
targeting
molecules
like
nuclear
factor‐kappa
B
(NF‐κB),
mitogen‐activated
protein
kinases
(MAPKs),
phosphoinositide
3‐kinase
(PI3K)/Akt,
thereby
inhibiting
survival
pathways
promoting
apoptosis
cells.
Moreover,
influences
expression
tumor
suppressor
genes,
curtails
migration
invasion,
modulates
tumour
microenvironment.
Despite
promising
preclinical
evidence,
further
research
is
essential
comprehensively
elucidate
mechanisms
action
evaluate
safety
clinical
settings.
In
present
review,
we
have
highlighted
pharmacokinetics,
biosynthesis,
recent
work
done
pertaining
berberine's
strong
activity.
We
also
emphasised
on
being
nanoformulations
berberine,
which
aim
improve
stability
bioavailability.
