Ecological and public health dimensions of ESBL-producing Escherichia coli in bats: A One Health perspective
Veterinary World,
Год журнала:
2025,
Номер
unknown, С. 1199 - 1213
Опубликована: Май 1, 2025
Background
and
Aim:
The
emergence
global
dissemination
of
extended-spectrum
β-lactamase
(ESBL)-producing
Escherichia
coli
represent
a
major
public
health
concern.
While
antibiotic
resistance
in
clinical
agricultural
settings
is
well
documented,
the
contribution
wildlife,
particularly
bats,
to
spread
antimicrobial
(AMR)
remains
underexplored.
Bats
possess
unique
ecological
traits
–
such
as
long-distance
flight,
longevity,
adaptability
that
facilitate
their
role
potential
reservoirs
vectors
antibiotic-resistant
bacteria.
This
review
synthesizes
findings
on
occurrence,
genetic
characteristics,
transmission
dynamics
ESBL-producing
E.
isolated
from
bats.
Through
comprehensive
literature
studies
conducted
across
five
continents,
we
highlight
prevalence
multidrug-resistant
bat
populations,
with
profiles
frequently
including
β-lactams
(bla),
aminoglycosides,
tetracyclines,
fluoroquinolones.
Notably,
key
ESBL
genes
blaCTX-M,
blaTEM,
blaSHV,
blaOXA
have
been
identified
isolates
feces
(guano),
raising
significant
concern
due
environmental
contamination
zoonotic
spillover.
Risk
factors
habitat
encroachment,
anthropogenic
waste
exposure,
use
guano
further
exacerbate
risk
transmission.
Moreover,
genomic
comparisons
suggest
phylogenetic
overlap
between
bats
those
found
humans
livestock.
Given
these
findings,
warrant
greater
inclusion
One
Health
surveillance
frameworks
trace
AMR
gene
flow
develop
targeted
interventions.
underscores
need
for
integrated
monitoring
enhanced
management
policies,
stricter
biosecurity
mitigate
risks
associated
wildlife-origin
dissemination.
Keywords:
resistance,
coli,
β-lactamase,
guano,
Health,
surveillance,
zoonosis.
Язык: Английский
How can the microbial community in watershed sediment maintain its resistance in the presence of shifting antibiotic residuals?
Journal of Environmental Management,
Год журнала:
2024,
Номер
368, С. 122242 - 122242
Опубликована: Авг. 19, 2024
Язык: Английский
Assessment of health risk of antibiotics resistance genes from human disturbed habitat to wild animals: Metagenomic insights into availability and functional changes of gut microbiome
Ecotoxicology and Environmental Safety,
Год журнала:
2024,
Номер
285, С. 117117 - 117117
Опубликована: Сен. 28, 2024
Язык: Английский