Journal of the American Chemical Society,
Год журнала:
2020,
Номер
142(22), С. 9884 - 9889
Опубликована: Апрель 27, 2020
Palladium-catalyzed
Suzuki–Miyaura
cross-coupling
reactions
of
liquid,
unbiased
dibromoarenes
under
mechanochemical
conditions
selectively
afford
the
monoarylated
products.
The
lower
reactivity
crystalline
products
relative
to
liquid
starting
materials
should
be
attributed
predominantly
low
diffusion
efficiency
former
in
reaction
mixture,
which
results
a
selective
monoarylation.
present
study
sheds
light
on
novel
approach
using
situ
phase
transitions
solids
design
organic
transformations
that
are
difficult
achieve
via
conventional
solution-based
synthesis.
ACS Sustainable Chemistry & Engineering,
Год журнала:
2019,
Номер
7(8), С. 7951 - 7959
Опубликована: Март 15, 2019
Phosphorylated
polymers
are
versatile
materials
for
a
broad
range
of
applications
from
flame-retardant
coatings
to
bioactive
scaffolds.
Traditionally,
they
synthesized
in
solution
using
corrosive
concentrated
phosphoric
acid
and
energy-intensive
drying
techniques.
In
the
past
decade,
mechanochemistry
has
proven
be
valuable
tool
green
chemists
conduct
new
transformations,
with
minimal
waste,
often
solvent-free.
This
work
presents
phosphorylation
cellulose
nanocrystals,
poly(ethylene
glycol),
poly(vinyl
alcohol),
chloride),
lignin
through
mechanochemical
processes
phosphorus
pentoxide
produce
reproducible
potential
applications.
Through
31P
magic
angle
spinning
(MAS)
NMR,
loadings
up
3300
mmol/kg
were
determined
far
superior
around
1600
mmol/kg,
4375
obtained
synthetic
such
as
alcohol).
Chemical Communications,
Год журнала:
2018,
Номер
54(32), С. 4033 - 4036
Опубликована: Янв. 1, 2018
Resonant
acoustic
mixing
(RAM)
is
a
new
technology
designed
for
intensive
of
powders
that
offers
the
capability
to
process
with
minimal
damage
particles.
This
feature
particularly
important
impact-sensitive
materials
such
as
explosives
and
propellants.
While
RAM
technique
has
been
extensively
employed
viscous
polymers,
comparatively
little
known
about
its
use
mechanosynthesis.
We
present
here
first
in
situ
study
RAM-induced
co-crystallisation
monitored
using
synchrotron
X-ray
powder
diffraction.
The
phase
profile
reaction
between
nicotinamide
carbamazepine
presence
small
amount
water
was
at
two
different
relative
accelerations
mixer.
In
marked
contrast
ball-milling
techniques,
lack
milling
bodies
experiment
does
not
hinder
starting
materials,
which
occurred
readily
independent
frequency
oscillation.
could
be
optimised
by
enhancing
number
reactive
contacts
through
comminution.
These
observations
provide
insight
into
role
various
experimental
parameters
conventional
mechanochemistry
liquid-assisted
grinding
techniques.
Angewandte Chemie International Edition,
Год журнала:
2018,
Номер
57(49), С. 16104 - 16108
Опубликована: Окт. 18, 2018
Abstract
A
reaction
manifold
has
been
discovered
in
which
the
chemoselectivity
can
be
altered
by
switching
between
neat
milling
and
liquid
assisted
grinding
(LAG)
with
polar
additives.
After
investigation
of
mechanism,
it
established
that
this
pathway
is
due
to
mechanochemical
conditions
exhibiting
different
kinetics
for
a
key
step
transformation.
This
proof
concept
study
demonstrates
mechanochemistry
used
trap
kinetic
product
reaction.
It
envisaged
that,
if
successfully
applied
other
transformations,
novel
synthetic
processes
could
known
pathways
perturbed
or
diverted.
Journal of the American Chemical Society,
Год журнала:
2020,
Номер
142(22), С. 9884 - 9889
Опубликована: Апрель 27, 2020
Palladium-catalyzed
Suzuki–Miyaura
cross-coupling
reactions
of
liquid,
unbiased
dibromoarenes
under
mechanochemical
conditions
selectively
afford
the
monoarylated
products.
The
lower
reactivity
crystalline
products
relative
to
liquid
starting
materials
should
be
attributed
predominantly
low
diffusion
efficiency
former
in
reaction
mixture,
which
results
a
selective
monoarylation.
present
study
sheds
light
on
novel
approach
using
situ
phase
transitions
solids
design
organic
transformations
that
are
difficult
achieve
via
conventional
solution-based
synthesis.
