Abstract
A
simple
and
beneficial
strategy
for
the
construction
of
2,3‐dihydrofurans
from
α‐bromochalcones
α‐substituted
cyanoketones
via
Michael
addition‐alkylation
reaction
has
been
realized.
This
transformation
was
well
compatible
with
various
cyanoketones,
corresponding
multifunctionalized
were
obtained
in
up
to
98
%
yield.
highly
diastereoselective
variant
also
developed.
Moreover,
could
be
performed
on
gram‐scale.
Russian Chemical Reviews,
Год журнала:
2023,
Номер
92(12), С. RCR5104 - RCR5104
Опубликована: Дек. 1, 2023
After
the
appearance
of
green
chemistry
concept,
which
was
introduced
in
vocabulary
early
1990s,
its
main
statements
have
been
continuously
developed
and
modified.
Currently,
there
are
10–12
cornerstones
that
should
form
basis
for
an
ideal
chemical
process.
This
review
analyzes
accumulated
experience
achievements
towards
design
products
processes
reduce
or
eliminate
use
generation
hazardous
substances.
The
presents
views
leading
Russian
scientists
specializing
various
fields
this
subject,
including
homogeneous
heterogeneous
catalysis,
fine
basic
organic
synthesis,
electrochemistry,
polymer
chemistry,
based
on
bio-renewable
feedstocks
energetic
compounds
materials.
A
new
approach
to
quantitative
evaluation
environmental
friendliness
by
authors
is
described.
<br>
bibliography
includes
1761.
The Journal of Organic Chemistry,
Год журнала:
2024,
Номер
89(10), С. 6991 - 7003
Опубликована: Май 8, 2024
We
report
an
efficient
procedure
to
carry
out
palladium-catalyzed
Miyaura
borylation
reactions
of
(hetero)aromatic
halides
and
triflates
in
choline
chloride
(ChCl)-based
deep
eutectic
solvents
(DESs).
The
employs
bis(pinacolato)diboron
as
a
boron
source
catalyst
prepared
situ
from
readily
available
Pd2(dba)3
the
phosphine
ligand
XPhos.
Reactions
proceed
well
different
ChCl-based
DESs,
among
which
best
results
were
provided
by
environmentally
friendly
biodegradable
mixtures
with
glycerol
glucose.
reaction
tolerates
both
EDG
EWG
substituents
on
substrates
can
be
run
(chloride,
bromide,
iodide)
pseudohalides
(triflate).
Furthermore,
for
several
substrates,
loading
reduced
1
mol
%
Pd
(0.5%
Pd2(dba)3)
without
compromising
yield.
Moreover,
we
show
that
protocol
DES
combined
subsequent
Suzuki–Miyaura
cross-coupling
one-pot
procedure,
allowing
access
various
biaryl
products
demonstrating
its
synthetic
utility
preparing
precursors
two
compounds
reported
applications
photovoltaics
sector.
Finally,
green
metrics
(E-factor
EcoScale)
new
calculated
compared
literature
values
assess
potential
advantages
terms
waste
reduction,
safety,
energy
consumption.
Cell Reports Physical Science,
Год журнала:
2024,
Номер
5(3), С. 101838 - 101838
Опубликована: Фев. 21, 2024
Although
"on-water"
organic
reactions,
including
organometallics,
are
a
sustainable
alternative
to
traditional
strategies,
serious
concerns
related
the
safety
and
feasibility
of
large-scale
application
exist.
Here,
on-water
continuous-flow
addition
organolithium
reagents
imines
is
studied
in
continuous
stirred
tank
reactor.
Fast
reaction
times
(10–20
s)
lead
more
productive
(gram
scale
2.5
mL
reactor)
safer
methodology
compared
in-batch
reaction.
A
calorimetric
study
performed
understand
thermal
behavior
critical
parameters
that
affect
process.
The
applied
synthesis
an
enantiopure
amine.
telescoped
process,
comprising
3
units
operation
(synthesis-inline
extraction-separation)
resembles
industrial
line,
developed,
demonstrating
scaleup.
Functionalized
secondary
amines
can
be
synthesized
on
water,
continuo,
with
high
yields
very
short
times.
Molecules,
Год журнала:
2024,
Номер
29(6), С. 1399 - 1399
Опубликована: Март 21, 2024
An
enhanced,
sustainable,
and
efficient
method
for
synthesizing
tacrine,
achieving
a
98%
yield,
has
been
developed
by
replacing
volatile
organic
compounds
with
more
eco-friendly
solvents
such
as
deep
eutectic
solvent
(DESs).
The
optimized
protocol
scales
easily
to
3
g
of
substrate
without
yield
loss
extends
successfully
tacrine
derivatives
reduced
hepatotoxicity.
Particularly
notable
is
the
synthesis
novel
triazole-based
derivatives,
yielding
90–95%,
integrating
an
in
situ
preparation
aryl
azides
DESs
N-propargyl-substituted
derivatives.
Quantitative
metrics
validate
green
aspects
reported
drug
development
processes.
Sustainable Energy & Fuels,
Год журнала:
2023,
Номер
8(3), С. 504 - 515
Опубликована: Дек. 11, 2023
DSSCs
based
on
a
DES-like
mixture
containing
choline
iodide
as
main
component
have
been
tested,
in
combination
with
properly
hydrophobic
dye,
achieving
top-ranked
efficiency
without
any
other
source
under
both
outdoor
and
indoor
conditions.
Green Chemistry,
Год журнала:
2023,
Номер
25(13), С. 5123 - 5127
Опубликована: Янв. 1, 2023
The
Cu-DES-promoted
Glaser-type
homo-
and
cross-coupling
of
terminal
alkynes
under
exogenous-ligand-free,
base-free,
additive-free
conditions
is
described.
