Synlett,
Год журнала:
2023,
Номер
34(20), С. 2481 - 2485
Опубликована: Июль 31, 2023
Abstract
Traditional
amide
linkage
forming
reactions
by
the
coupling
between
an
acid
and
amine
rely
primarily
on
triggering
carboxylic
counterpart
with
(over)stoichiometric
activating
agent(s)
generate
unacceptable
quantity
of
nondisposable
waste,
leading
to
poor
atom
economy.
Herein,
we
report
efficient
catalytic
synthesis
that
proceeds
through
in
situ
activation
form
a
reactive
N-formyl
species.
The
strategy
gives
expedient
access
array
structurally
varied
amides,
including
dipeptides,
from
numerous
genre
acids
amines
without
producing
stoichiometric
solid
wastes.
Chemistry - A European Journal,
Год журнала:
2024,
Номер
unknown
Опубликована: Фев. 7, 2024
Abstract
Light‐mediated
processes
have
received
significant
attention,
since
they
re‐surfaced
unconventional
reactivity
platforms,
complementary
to
conventional
polar
chemistry.
γ‐Lactones
and
cyclopropanes
are
prevalent
moieties,
found
in
numerous
natural
products
pharmaceuticals.
Among
various
methods
for
their
synthesis,
light‐mediated
protocols
coming
the
spotlight,
although
these
contingent
upon
use
of
photoorgano‐
or
metal‐based
catalysts.
Herein,
we
introduce
a
novel
photochemical
activation
iodo‐reagents
via
cheap
sodium
ascorbate
ascorbic
acid
enable
homolytic
scission
addition
onto
double
bonds.
The
developed
protocol
was
applied
successfully
formal
[3+2]
cycloaddition
synthesis
γ‐lactones,
traditional
atom
transfer
radical
(ATRA)
reactions
one‐pot
two‐step
conversion
alkenes
cyclopropanes.
In
all
cases,
desired
were
obtained
good
high
yields,
while
reaction
mechanism
thoroughly
investigated.
Depending
on
nature
iodo‐reagent,
halogen
hydrogen‐bonded
complex
is
formed,
which
initiates
process.
Although
the
introduction
of
plastics
has
improved
humanity's
everyday
life,
fast
accumulation
plastic
waste,
including
microplastics
and
nanoplastics,
have
created
numerous
problems
with
recent
studies
highlighting
their
involvement
in
various
aspects
our
lives.
Upcycling
plastics,
conversion
waste
to
high-added
value
chemicals,
is
a
way
combat
that
receiving
increased
attention.
Herein,
we
describe
novel
aerobic
photochemical
process
for
upcycling
real-life
polystyrene-based
into
benzoic
acid.
A
new
employing
thioxanthone-derivative,
combination
N-bromosuccinimide,
under
ambient
air
390
nm
irradiation
capable
polystyrene-derived
products
acid
yields
varying
from
24-54
%.
ACS Sustainable Chemistry & Engineering,
Год журнала:
2024,
Номер
12(35), С. 13382 - 13391
Опубликована: Авг. 20, 2024
Very
acidic
pHs
are
not
allowed
in
wood
adhesives.
The
development
of
new
self-neutralizing
adhesives
has
therefore
become
a
priority.
corn
starch–citric
acid
adhesive
(CACS)
was
developed
recently
to
be
an
environmentally
friendly
biomass
adhesive.
In
this
work,
we
propose
prepare
starch
using
the
CACS
as
matrix
and
morpholine/maleic
(MM)
morpholine/d-lactic
(DM)
neutralizing
agents.
results
showed
that
MM
additive
is
more
effective
than
DM
eliminating
residual
on
glue
line.
When
addition
neutralizer
10%,
pH
system
increased
about
4.5
with
stable
water
resistance,
good
durability,
high
bonding
strength
durability
acceptable
relevant
standards
could
maintained.
Structural
analysis
proved
MA
also
involved
esterification
reaction
(CS).
Therefore,
MM-CACS
study
potential
replace
traditional
petroleum-based
type
Chemistry - A European Journal,
Год журнала:
2024,
Номер
30(44)
Опубликована: Июнь 4, 2024
Abstract
Plastic
pollution
constitutes
an
evergrowing
urgent
environmental
problem,
since
overaccumulation
of
plastic
waste,
arising
from
the
immense
increase
production
disposable
products,
overcame
planet's
capacity
to
properly
handle
them.
Chemical
upcycling
polystyrene
a
convenient
method
for
conversion
waste
into
high‐added
value
chemicals,
suggesting
attractive
perspective
in
dealing
with
crisis.
We
demonstrate
herein
novel,
easy‐to‐perform
organocatalytic
photoinduced
aerobic
protocol,
which
proceeds
via
synergistic
indirect
hydrogen
atom
transfer
(HAT)
catalysis
under
LED
390
nm
Kessil
lamps
as
irradiation
source.
The
developed
employs
BrCH
2
CN‐thioxanthone
photocatalytic
system
and
was
successfully
applied
variety
everyday‐life
leading
isolation
benzoic
acid
after
simple
base‐acid
work
up
yields
varying
23–49
%,
while
large‐scale
experiment
performed,
that
step
is
susceptible
industrial
application.
In
recent
years,
halogen-bonded
complexes
(XBCs),
in
solution,
have
played
a
pivotal
role
inducing
photochemical
organic
reactions.
this
work,
we
explore
the
ability
of
various
tertiary
amines
to
act
as
XB
acceptors
presence
donor
CBr
European Journal of Organic Chemistry,
Год журнала:
2023,
Номер
26(30)
Опубликована: Июнь 24, 2023
Abstract
A
visible
light
mediated
protocol
for
the
synthesis
of
polyhalogenated
and
deuterated
δ‐
γ‐lactams
from
readily
available
alkyl
halides
is
reported.
The
reaction
involves
generation
haloalkyl
radicals
through
halogen
atom
transfer
(XAT)
subsequent
arylalkylation
olefins
to
afford
dihydroisoquinolinones
oxindoles.
This
new
XAT
exhibits
wide
scope
under
mild
conditions
enables
access
halogenated
chemical
space.
Abstract
We
report
a
useful
flow
protocol
for
the
preparation
of
alkenyl
thioethers
from
bromides
and
thiols
in
basic
media
with
visible-light
irradiation.
The
reactions
exhibit
wide
functional-group
tolerance,
proceed
under
mild
conditions,
are
stereoselective,
do
not
require
use
catalysts.
transformations
can
be
successfully
scaled
up
to
5
mmol
scale
without
compromising
yield.
key
success
these
is
photochemical
excitation
halogen-bonding
complexes
form
sulfur-centered
radicals,
recently
developed
our
laboratories.
Chemistry - A European Journal,
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 30, 2024
Abstract
The
hydroxamic
acid
functionality
is
present
in
various
medicinal
agents
and
has
attracted
special
interest
for
synthetic
transformations
both
organic
chemistry.
N−O
bond
cleavage
of
derivatives
provides
an
interesting
transformation
the
generation
products.
We
demonstrate,
herein,
that
O
‐benzyl‐type
protected
acids
may
undergo
photochemical
cleavage,
presence
or
absence
a
catalyst,
leading
to
amides.
Although
some
‐benzyl
aromatic
hydroxamates
be
photochemically
converted
amides
base
anthracene
as
employing
‐2‐nitrobenzyl
group
allowed
smooth
conversion
aliphatic
primary
secondary
good
excellent
yields
amine,
bypassing
need
catalyst.
DFT
UV‐Vis
studies
supported
effective
electron
donor‐acceptor
(EDA)
complex
between
amines,
which
enabled
successful
product
formation
under
these
conditions.
An
extensive
substrate
scope
was
demonstrated,
showcasing
are
compatible
with
this
protocol,
affording
wide
variety
Chemical Science,
Год журнала:
2024,
Номер
unknown
Опубликована: Янв. 1, 2024
A
new
photochemical
method
to
prepare
alkenyl
thioethers
under
both
batch
and
continuous
flow
conditions
is
presented.
These
versatile
building
blocks
enable
the
synthesis
of
various
organosulfur
compounds,
highlighting
utility
this
procedure.
