Recent progress in visible light‐driven halogenation: Chlorination, bromination, and iodination
Bulletin of the Korean Chemical Society,
Год журнала:
2024,
Номер
45(9), С. 738 - 758
Опубликована: Сен. 1, 2024
Abstract
Halogenation
is
one
of
the
most
important
transformations
in
organic
synthesis.
Halogenated
compounds
are
employed
many
reactions
to
prepare
useful
molecules.
Many
methods
have
been
developed
introduce
halogens
into
different
compounds.
Visible
light‐mediated
efficient,
low‐toxic,
and
mild‐condition
applied
for
various
chemistry
transformations.
Remarkably,
there
has
an
increasing
development
application
visible
light‐induced
halogenation
recent
years.
Herein,
we
present
a
comprehensive
summary
including
chlorination,
bromination,
iodination
under
light
irradiation
since
2020.
Язык: Английский
Ligand-Promoted Remote γ-C(sp3)–H Chlorination and Bromination of Alcohols
The Journal of Organic Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 4, 2025
Herein,
we
report
a
Pd(II)-catalyzed
protocol
f-C(sp3)–H
chlorination
and
bromination
of
aliphatic
alcohols
using
NCS
NBS
as
the
halogenating
reagents.
The
addition
2-pyridone
ligand
base
was
crucial
to
success
reaction.
method
showed
excellent
functional
group
tolerance.
gram-scale
reaction
facile
removal
directing
demonstrated
its
potential
application
in
synthesis
γ-chloro
or
bromo
containing
quaternary
carbon.
Язык: Английский
C−H Functionalization of Aldehydes and Ketones with Transient Directing Groups: Recent Developments
European Journal of Organic Chemistry,
Год журнала:
2023,
Номер
26(31)
Опубликована: Июль 4, 2023
Abstract
In
order
to
directly
functionalize
C−H
bonds
of
complex
molecules
and,
in
particular,
control
the
regioselectivity
reaction,
a
wide
range
directing
groups
has
been
used.
However,
these
need
be
installed
and
removed
for
further
applications,
which
may
limit
use
activation
synthesis.
Concerning
aldehydes
ketones,
transient
group
strategy
recently
emerged
overcome
this
drawback.
The
addition
an
additive,
general
amine,
allowed
situ
formation
real
achieve
activation.
This
review
presents
latest
developments
field
over
period
2020–2023.
Язык: Английский
Palladium‐Catalyzed C8‐Fluoroalkylation and C8‐Fluoroalkenylation of Naphthalenes by C−H Activation
European Journal of Organic Chemistry,
Год журнала:
2024,
Номер
27(20)
Опубликована: Март 7, 2024
Abstract
In
this
study,
two
novel
C8‐functionalization
methods
of
1‐carbonylnaphthalenes
were
developed.
Leveraging
iodonium
triflates
as
coupling
partners,
we
disclose
palladium‐catalyzed
C8‐fluoroalkylation
and
C8‐fluoroalkenylation
processes.
These
protocols
exhibit
broad
applicability
across
diverse
naphthalene
derivatives,
owing
to
carbonyl
directing
groups
at
the
C1
position
which
can
be
retained
for
subsequent
applications
or
selectively
removed,
enhancing
versatility
developed
methodologies.
Язык: Английский
Recent advances in site-selective C H functionalization of naphthalenes: An update 2020–2024
Tetrahedron Letters,
Год журнала:
2024,
Номер
154, С. 155370 - 155370
Опубликована: Ноя. 17, 2024
Язык: Английский
Synthesis of naphtholactams and their biological evaluation against Pseudomonas aeruginosa
ARKIVOC,
Год журнала:
2023,
Номер
2024(2)
Опубликована: Окт. 24, 2023
The
naphtholactam
scaffold
can
be
found
in
a
lot
of
natural
products
or
bioactive
compounds,
with
some
previous
reports
highlighting
its
antibacterial
properties.In
this
context,
we
report
the
synthesis
library
naphtholactams
bearing
various
functional
groups
and
their
biological
evaluation
against
bacterium
Pseudomonas
aeruginosa.Their
was
accomplished
through
concise
three-step
process,
from
readily
available
naphthaldehydes,
involving
palladium-catalyzed
C8-bromination
followed
by
an
oxidation/lactam
formation
sequence.
Язык: Английский