Enzyme-Initiated Devulcanization of Silicone–Gelatin Elastomers

ACS Sustainable Chemistry & Engineering, Год журнала: 2025, Номер unknown

Опубликована: Янв. 22, 2025

Язык: Английский

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Interfacial polymerization of dopamine with diamines for ultrastable Janus nanofiltration membranes and adhesives

Materials Today, Год журнала: 2025, Номер unknown

Опубликована: Апрель 1, 2025

Язык: Английский

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Non-isocyanate polyurethanes at room temperature – a dream becoming reality

Progress in Polymer Science, Год журнала: 2025, Номер unknown, С. 101968 - 101968

Опубликована: Май 1, 2025

Язык: Английский

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Nitrative Difunctionalization of Alkenes via Cobalt-Mediated Radical Ligand Transfer and Radical-Polar Crossover Photoredox Catalysis

ACS Catalysis, Год журнала: 2023, Номер 13(24), С. 16136 - 16147

Опубликована: Дек. 1, 2023

Herein, we report the rational design of a modular dual photoredox and cobalt catalysis paradigm for difunctionalization unsaturated hydrocarbons, unlocking synthesis valuable but challenging 1,2-halonitroalkane substrate class. The protocol relies on use redox-active organic nitrating reagent N-nitrosuccinimide as source nitryl radicals cobalt-mediated radical ligand transfer (RLT) methodology to form carbon–halogen bond. This synergistic cooperation between photocatalyst high-valence metal center occurs under mild reaction conditions is capable delivering 1,2-chloronitro- 1,2-bromonitroalkanes in single chemical operation while exhibiting high functional-group tolerance exclusive regioselectivity variety olefins. Mechanistic studies based both experimental spectroscopic analysis provided insights into nature this catalytic halo-nitration process including evidence halogen catalyst. Furthermore, employing net-neutral radical/polar crossover (RPC) approach cobalt-free allowed us accommodate external protic nucleophiles, thiols, alcohols, acids, and, notably, substituted amines. Highly functionalized olefin scaffolds also successfully underwent nitrative difunctionalization, demonstrating viability these protocols late-stage functionalization bioactive molecules.

Язык: Английский

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Pyridine-catalyzed ring-opening reaction of cyclopropenone with bromomethyl carbonyl compounds toward furan-2(5H)-ones

Chemical Communications, Год журнала: 2024, Номер 60(14), С. 1900 - 1903

Опубликована: Янв. 1, 2024

We developed a pyridine-catalyzed annulation of diaryl cyclopropenone with bromomethyl carbonyl compounds leading to 5-carbonyl furan-2(5 H )-ones.

Язык: Английский

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Understanding selectivity of nucleophilic addition to β-formyl-α-haloenoates: A synthetic and theoretical investigation

Tetrahedron, Год журнала: 2024, Номер 155, С. 133892 - 133892

Опубликована: Фев. 22, 2024

Язык: Английский

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Advanced green synthesis: Solvent-free and catalyst-free reaction

Green Synthesis and Catalysis, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 1, 2024

Язык: Английский

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PAMAM-Calix-Dendrimers: Third Generation Synthesis and Impact of Generation and Macrocyclic Core Conformation on Hemotoxicity and Calf Thymus DNA Binding

Pharmaceutics, Год журнала: 2024, Номер 16(11), С. 1379 - 1379

Опубликована: Окт. 27, 2024

Background/Objectives: Current promising treatments for many diseases are based on the use of therapeutic nucleic acids, including DNA. However, list nanocarriers is limited due to their low biocompatibility, high cost, and toxicity. The design synthetic building blocks creating universal delivery systems genetic material an unsolved problem. In this work, we propose PAMAM dendrimers with rigid thiacalixarene core in various conformations, i.e., PAMAM-calix-dendrimers, as a platform supramolecular constructor nanomedicine. Results: Third generation macrocyclic three conformations (cone, partial cone, 1,3-alternate) were synthesized first time. obtained capable binding compacting calf thymus DNA, whereby efficiency improved increasing generation, while influence was reduced. A dramatic effect conformation hemolytic activity PAMAM-calix-dendrimers observed. Specifically, notable reduction hemotoxicity associated decrease compound amphiphilicity. Conclusions: We hope results will help reduce financial labor costs developing new drug dendrimers.

Язык: Английский

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Sequential Photocatalysis for Homologative Diversification of α-Amino Acids to β-Amino Acids Via Phosphonium Ylide Linchpin Strategy

Journal of the American Chemical Society, Год журнала: 2024, Номер unknown

Опубликована: Дек. 12, 2024

β-Amino acids serve as crucial building blocks for a broad range of biologically active molecules and peptides with potential peptidomimetics. While numerous methods have been developed the synthesis β-amino acids, most them require multistep preparation specific reagents substrates, which limits their synthetic practicality. In this regard, homologative transformation abundant readily available α-amino would be an attractive approach acid synthesis. Herein, we disclose development sequential process to provide diverse from derivatives commercially phosphonium ylides via visible light photoredox catalysis. two-step protocol, function bifunctional linchpin: they act carbon nucleophile forge C-C bond in first step carbon-centered radical source modifications scaffold second step. The orthogonal activation these reactivities under mild photocatalytic conditions enables modular three-component assembly access dipeptides high structural diversity.

Язык: Английский

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Synthesis and Characterization of Gold(I) N-Heterocyclic Carbenes Complexes Bearing Methacrylate Moiety

Journal of Organometallic Chemistry, Год журнала: 2025, Номер unknown, С. 123514 - 123514

Опубликована: Янв. 1, 2025

Язык: Английский

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