New Journal of Chemistry, Год журнала: 2024, Номер 48(37), С. 16155 - 16158
Опубликована: Янв. 1, 2024
A nickel-catalyzed synthesis of hydrazoarenes utilizing NH 3 BH in water has been developed.
Язык: Английский
Organic & Biomolecular Chemistry, Год журнала: 2024, Номер 22(19), С. 3860 - 3865
Опубликована: Янв. 1, 2024
The aminophosphinoylation of alcohols with amines and H-phosphine oxides provides an efficient mild approach to access various α-aminoalkylphosphine in good yields tolerance functional groups using H 2 O as a clean solvent.
Язык: Английский
Процитировано
4
Organic Letters, Год журнала: 2024, Номер 26(30), С. 6413 - 6417
Опубликована: Июль 22, 2024
Nickel-catalyzed aqueous cyanation of allylic alcohols is herein described. This catalytic protocol provided environmentally friendly and operationally simple access to a variety nitriles in good yields. For chiral alcohols, the reaction gave with high degree inversion. The accelerated release cyanide H
Язык: Английский
Процитировано
3
The Journal of Organic Chemistry, Год журнала: 2024, Номер 89(14), С. 10344 - 10348
Опубликована: Июль 10, 2024
A mild and green synthesis of allylic sulfones from alcohols sulfonyl hydrazines was developed in water media. The simple commercially available Pd(PPh
Язык: Английский
Процитировано
3
Organic & Biomolecular Chemistry, Год журнала: 2024, Номер 22(11), С. 2307 - 2312
Опубликована: Янв. 1, 2024
Phytic acid is abundant in various plant-based foods and considered agricultural waste. Here, we demonstrate the effectiveness of this organophosphorus as a sustainable catalyst for direct amination reactions allylic alcohols. This approach successfully performed air using technical grade solvents, affording allylanilines moderate to excellent yields. Challenging electron-rich anilines react effectively, their corresponding Friedel-Crafts side products can be minimised under optimised reaction conditions. A variety asymmetrically substituted alcohols are tolerated, while scope extended amide,
Язык: Английский
Процитировано
2
The Journal of Organic Chemistry, Год журнала: 2024, Номер 89(22), С. 16510 - 16521
Опубликована: Ноя. 4, 2024
Aliphatic allylic amines are present in a large number of complex and pharmaceutically relevant molecules. The direct amination electrophiles serves as the most common method toward preparation these motifs. However, use feedstock reaction components (allyl alcohol aliphatic amine) transformations remains great challenge. Such challenge primarily stems from high Lewis basicity steric hindrance amines, addition to low reactivity alcohols. Herein, we report general solution challenges. developed protocol allows an efficient allyl alcohols with sterically bulky presence inexpensive earth-abundant molybdenum complex. This simple economic also enables regioselective branched amination; practicality was shown efficient, scaled-up synthesis several drugs.
Язык: Английский
Процитировано
1
Journal of Chemical Education, Год журнала: 2024, Номер 101(6), С. 2493 - 2497
Опубликована: Май 17, 2024
The preparation of n-bromobutane is one the required training items in Experimental Organic Chemistry for undergraduates. However, there are still drawbacks: reaction process not easy to monitor, and yield low (∼50%) available experimental protocols. In this improved experiment, visual was realized through ingenious use a Dean–Stark apparatus. Moreover, postprocessing steps were simplified: while proceeding, separation purification conducted at same time, thus leading an increase product (from ∼50% ∼70%). As result, protocol provides conveniences students observe intuitively accurately by using obvious stratification phenomenon apparatus teaching. it also expands scope stimulates students' interest learning organic chemistry. experiment has good cost-effectiveness takes ∼3 class hours, which fairly suitable be widely used undergraduate
Язык: Английский
Процитировано
0
New Journal of Chemistry, Год журнала: 2024, Номер 48(37), С. 16155 - 16158
Опубликована: Янв. 1, 2024
A nickel-catalyzed synthesis of hydrazoarenes utilizing NH 3 BH in water has been developed.
Язык: Английский
Процитировано
0