The Visual Preparation of n-Bromobutane DOI
Xiantao Ma, Jing Yu, Feng Liu

et al.

Journal of Chemical Education, Journal Year: 2024, Volume and Issue: 101(6), P. 2493 - 2497

Published: May 17, 2024

The preparation of n-bromobutane is one the required training items in Experimental Organic Chemistry for undergraduates. However, there are still drawbacks: reaction process not easy to monitor, and yield low (∼50%) available experimental protocols. In this improved experiment, visual was realized through ingenious use a Dean–Stark apparatus. Moreover, postprocessing steps were simplified: while proceeding, separation purification conducted at same time, thus leading an increase product (from ∼50% ∼70%). As result, protocol provides conveniences students observe intuitively accurately by using obvious stratification phenomenon apparatus teaching. it also expands scope stimulates students' interest learning organic chemistry. experiment has good cost-effectiveness takes ∼3 class hours, which fairly suitable be widely used undergraduate

Language: Английский

TEMPO/PhI(OAc)2 promotes the α-aminophosphinoylation of alcohols with amines and H-phosphine oxides in aqueous medium DOI

Qiang Huang,

Xin Jin,

Lvjia Wu

et al.

Organic & Biomolecular Chemistry, Journal Year: 2024, Volume and Issue: 22(19), P. 3860 - 3865

Published: Jan. 1, 2024

The aminophosphinoylation of alcohols with amines and H-phosphine oxides provides an efficient mild approach to access various α-aminoalkylphosphine in good yields tolerance functional groups using H 2 O as a clean solvent.

Language: Английский

Citations

4
Nickel-Catalyzed Cyanation of Allylic Alcohols: High Degree of Chiral Inversion in Aqueous Reaction Media DOI
Yaxin Liu, Jiawen Hu,

Jinguo Long

et al.

Organic Letters, Journal Year: 2024, Volume and Issue: 26(30), P. 6413 - 6417

Published: July 22, 2024

Nickel-catalyzed aqueous cyanation of allylic alcohols is herein described. This catalytic protocol provided environmentally friendly and operationally simple access to a variety nitriles in good yields. For chiral alcohols, the reaction gave with high degree inversion. The accelerated release cyanide H

Language: Английский

Citations

3
Naturally occurring phytic acid: an advanced Brønsted acid catalyst for direct amination reactions of allylic alcohols DOI

Van-Can Pham,

Warinthorn Chavasiri, Lalita Radtanajiravong

et al.

Organic & Biomolecular Chemistry, Journal Year: 2024, Volume and Issue: 22(11), P. 2307 - 2312

Published: Jan. 1, 2024

Phytic acid is abundant in various plant-based foods and considered agricultural waste. Here, we demonstrate the effectiveness of this organophosphorus as a sustainable catalyst for direct amination reactions allylic alcohols. This approach successfully performed air using technical grade solvents, affording allylanilines moderate to excellent yields. Challenging electron-rich anilines react effectively, their corresponding Friedel-Crafts side products can be minimised under optimised reaction conditions. A variety asymmetrically substituted alcohols are tolerated, while scope extended amide,

Language: Английский

Citations

2
Pd-Catalyzed Aerobic Synthesis of Allylic Sulfones from Allylic Alcohols and Sulfonyl Hydrazines in Water DOI
Jing Yu, Xiaoyu Yan, Yuying Chen

et al.

The Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: 89(14), P. 10344 - 10348

Published: July 10, 2024

A mild and green synthesis of allylic sulfones from alcohols sulfonyl hydrazines was developed in water media. The simple commercially available Pd(PPh

Language: Английский

Citations

2
Molybdenum Complex-Catalyzed N-Alkylation of Bulky Primary and Secondary Amines DOI
Lingling Wang, Shahid Khan, Shahida Perveen

et al.

The Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: 89(22), P. 16510 - 16521

Published: Nov. 4, 2024

Aliphatic allylic amines are present in a large number of complex and pharmaceutically relevant molecules. The direct amination electrophiles serves as the most common method toward preparation these motifs. However, use feedstock reaction components (allyl alcohol aliphatic amine) transformations remains great challenge. Such challenge primarily stems from high Lewis basicity steric hindrance amines, addition to low reactivity alcohols. Herein, we report general solution challenges. developed protocol allows an efficient allyl alcohols with sterically bulky presence inexpensive earth-abundant molybdenum complex. This simple economic also enables regioselective branched amination; practicality was shown efficient, scaled-up synthesis several drugs.

Language: Английский

Citations

1
Nickel-Catalyzed highly Efficient Chemoselective Reduction of Azoarenes to Hydrazoarenes in Water DOI
Dawei Gong, Qixuan Li, Yufei Li

et al.

New Journal of Chemistry, Journal Year: 2024, Volume and Issue: 48(37), P. 16155 - 16158

Published: Jan. 1, 2024

A nickel-catalyzed synthesis of hydrazoarenes utilizing NH 3 BH in water has been developed.

Language: Английский

Citations

0
The Visual Preparation of n-Bromobutane DOI
Xiantao Ma, Jing Yu, Feng Liu

et al.

Journal of Chemical Education, Journal Year: 2024, Volume and Issue: 101(6), P. 2493 - 2497

Published: May 17, 2024

The preparation of n-bromobutane is one the required training items in Experimental Organic Chemistry for undergraduates. However, there are still drawbacks: reaction process not easy to monitor, and yield low (∼50%) available experimental protocols. In this improved experiment, visual was realized through ingenious use a Dean–Stark apparatus. Moreover, postprocessing steps were simplified: while proceeding, separation purification conducted at same time, thus leading an increase product (from ∼50% ∼70%). As result, protocol provides conveniences students observe intuitively accurately by using obvious stratification phenomenon apparatus teaching. it also expands scope stimulates students' interest learning organic chemistry. experiment has good cost-effectiveness takes ∼3 class hours, which fairly suitable be widely used undergraduate

Language: Английский

Citations

0