Organic Letters, Год журнала: 2024, Номер 26(30), С. 6449 - 6453
Опубликована: Июль 22, 2024
Herein, we report a visible-light-induced iridium-promoted direct bifunctionalization of 3-butenoic acid with bromodifluoromethyl heteroarylsulfones. This methodology enables the concurrent introduction difluoromethyl heteroarylsulfone and bromine groups into under mild reaction conditions. Various
Язык: Английский
Angewandte Chemie International Edition, Год журнала: 2024, Номер unknown
Опубликована: Апрель 10, 2024
The photoredox electron donor-acceptor (EDA) complex-mediated radical coupling reaction has gained prominence in the field of organic synthesis, finding widespread application two-component reactions. However, EDA complex-promoted multi-component reactions are not well developed with only a limited number examples have been reported. Herein, we report photoinduced and highly chemoselective three-component arylalkylation [1.1.1]propellane, which allows direct functionalization C(sp
Язык: Английский
Процитировано
13
Angewandte Chemie, Год журнала: 2024, Номер 136(39)
Опубликована: Апрель 10, 2024
Abstract The photoredox electron donor–acceptor (EDA) complex‐mediated radical coupling reaction has gained prominence in the field of organic synthesis, finding widespread application two‐component reactions. However, EDA complex‐promoted multi‐component reactions are not well developed with only a limited number examples have been reported. Herein, we report photoinduced and highly chemoselective three‐component arylalkylation [1.1.1]propellane, which allows direct functionalization C(sp 3 )−H bicyclo[1.1.1]pentanes (BCP)‐aryl groups under mild conditions. A variety unnatural α‐amino acids, featuring structurally diversified 1,3‐disubstituted BCP moieties, were synthesized single‐step process. Notably, leveraging high tension release unstable transient aryl undergoes rapid conversion into relatively stable tertiary alkyl radical, consequently, competing side‐reaction was entirely suppressed. strategic use this approach would be useful for design diverse It is noteworthy that late‐stage incorporation pharmacophores peptides achieved both liquid‐phase solid‐phase This advancement anticipated to significant potential future development peptide drugs.
Язык: Английский
Процитировано
3
ChemistrySelect, Год журнала: 2025, Номер 10(12)
Опубликована: Март 1, 2025
Abstract In light of the extensive application fluoroalkyl‐containing molecules and functionalized quinoxalin‐2(1 H )‐ones in medicinal chemistry functional materials, visible‐light‐enabled C3‐H fluoroalkylation has garnered significant attention. this review, we provide a detailed overview latest advancements rapidly evolving research area. We cover utilization various fluoroalkyl sources under conditions photocatalyst or without photocatalyst, discuss pertinent reaction conditions, mechanisms, substrate scope. Our objective is to help more chemists comprehend challenges opportunities within field, thereby fostering its development.
Язык: Английский
Процитировано
0
Organic Letters, Год журнала: 2024, Номер 26(30), С. 6449 - 6453
Опубликована: Июль 22, 2024
Herein, we report a visible-light-induced iridium-promoted direct bifunctionalization of 3-butenoic acid with bromodifluoromethyl heteroarylsulfones. This methodology enables the concurrent introduction difluoromethyl heteroarylsulfone and bromine groups into under mild reaction conditions. Various
Язык: Английский
Процитировано
0