Tunable base-controlled chemoselective synthesis of trifluoromethyl-containing N-substituted benzimidazole-2-thiones and monofluorinated 4H-benzo[4,5]imidazo[2,1-b][1,3]thiazine DOI

Yupian Deng,

Yuhao Qian,

Jia‐Qi Huang

и другие.

Organic & Biomolecular Chemistry, Год журнала: 2024, Номер unknown

Опубликована: Дек. 26, 2024

A base-controlled synthesis of N -β-CF 3 -substituted 2 H -benzo[ d ]imidazole-2-thiones and 2-fluoro-4 -benzo[4,5]imidazo[2,1- b ][1,3]thiazines via hydroamination or defluorinative cyclizations α-CF -styrenes with 2-mercaptobenzimidazole was developed.

Язык: Английский

Water-Controlled Geminal Hydroxyphosphinoylation and Diphosphinoylation of Enaminones with H-Phosphine Oxides DOI

Qiang Huang,

Xin Jin, Huabin Wang

и другие.

The Journal of Organic Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Март 6, 2025

A water-controlled geminal phosphinoylation of enaminones with H-phosphine oxides has been established through AlCl3-mediated C-N bond cleavage in this work, which provides a novel strategy for accessing various hydroxy and diphosphinoyl products 3a 4a high yields. The transformation features excellent functional group tolerance, operational simplicity, atom economy, is amenable complex molecule skeletons. Preliminary mechanism studies suggest the conversion from to involve elimination hydroxyl group, water temperature plays critical role influencing reaction pathway product selectivity. This research significant value functionalization enaminones.

Язык: Английский

Процитировано

0
Synthesis of 2‐(β‐Trifluoromethyl‐β‐arylethylthio)pyridine through DBU‐Mediated Regioselective Addition of Pyridine‐2(1H)‐thione Onto α‐(Trifluoromethyl)styrenes DOI

Pai Zheng,

Yupian Deng,

Jingjing He

и другие.

Asian Journal of Organic Chemistry, Год журнала: 2024, Номер 13(3)

Опубликована: Янв. 8, 2024

Abstract An efficient and practical method for the synthesis of (β‐trifluoromethyl‐β‐aryl)ethyl 2‐pyridyl thioethers via hydrothiolation α‐(trifluoromethyl)styrenes with pyridine‐2(1 H )‐thione was reported. The reaction proceeded smoothly regioselectively in an anti‐Markovnikov manner assistance DBU afforded a variety trifluoromethyl‐containing moderate to good yields.

Язык: Английский

Процитировано

3
Two-step synthesis of vicinal trifluoromethyl primary amines from α-(trifluoromethyl)styrenes and phthalimide DOI

Ying Liu,

Jia‐Qi Huang,

Zhudi Sun

и другие.

Organic & Biomolecular Chemistry, Год журнала: 2024, Номер 22(23), С. 4641 - 4646

Опубликована: Янв. 1, 2024

A novel two-step synthesis of β-trifluoromethyl primary amines from readily available α-(trifluoromethyl)styrenes and phthalimide is developed. The first step involves a hydroamination between (PhthNH) with the assistance base. Next, hydrazinolysis resulting

Язык: Английский

Процитировано

2
Visible-light-induced hydroxycarboxylation of α-trifluoromethylstyrenes to construct densely functionalized α-CF3 tertiary alcohols DOI

Min-Ming Lu,

Ning Deng, Shiyu Li

и другие.

Green Chemistry, Год журнала: 2024, Номер 26(15), С. 8694 - 8700

Опубликована: Янв. 1, 2024

Visible-light-induced hydroxycarboxylation of α-trifluoromethylstyrenes under an air atmosphere was developed to construct densely functionalized α-CF 3 tertiary alcohols.

Язык: Английский

Процитировано

1
Photoinduced Transition‐Metal‐Free Chemodivergent Phosphorylation‐Peroxidation and Oxyphosphorylation of Alkenes DOI
Jun Pan, Yuting Feng, Leiyang Lv

и другие.

Advanced Synthesis & Catalysis, Год журнала: 2024, Номер unknown

Опубликована: Авг. 22, 2024

Abstract A visible‐light‐promoted chemodivergent phosphorylation‐peroxidation and oxyphosphorylation of alkenes with phosphine oxides HOO t Bu was realized under transition‐metal‐free conditions. Using the commercially available Eosin Y as a SET‐photocatalyst, β ‐peroxy‐phosphine were selectively obtained catalytic amount base, while addition acid led to exclusive formation ‐keto‐phosphine control experiments showed that could also act HAT‐catalyst induce O−O bond cleavage peroxides acidic

Язык: Английский

Процитировано

1
Crystal structure of 1-(4-bromophenyl)-3-(diphenylphosphoryl)-3-hydroxypropan-1-one, C21H18BrO3P DOI Creative Commons
Yifan Liu,

Ronghai Cui,

Jialing Kang

и другие.

Zeitschrift für Kristallographie - New Crystal Structures, Год журнала: 2024, Номер 239(4), С. 731 - 733

Опубликована: Май 31, 2024

Abstract C 21 H 18 BrO 3 P, monoclinic, P 2 1 / c (no. 14), a = 20.2890(9) Å, b 5.9736(2) 16.1577(8) β 105.371(2)°, V 1888.24(14) Å , Z 4, R gt ( F ) 0.1359, w ref 0.1414, T 298.00 K.

Язык: Английский

Процитировано

0
Tunable base-controlled chemoselective synthesis of trifluoromethyl-containing N-substituted benzimidazole-2-thiones and monofluorinated 4H-benzo[4,5]imidazo[2,1-b][1,3]thiazine DOI

Yupian Deng,

Yuhao Qian,

Jia‐Qi Huang

и другие.

Organic & Biomolecular Chemistry, Год журнала: 2024, Номер unknown

Опубликована: Дек. 26, 2024

A base-controlled synthesis of N -β-CF 3 -substituted 2 H -benzo[ d ]imidazole-2-thiones and 2-fluoro-4 -benzo[4,5]imidazo[2,1- b ][1,3]thiazines via hydroamination or defluorinative cyclizations α-CF -styrenes with 2-mercaptobenzimidazole was developed.

Язык: Английский

Процитировано

0