The Journal of Organic Chemistry,
Год журнала:
2024,
Номер
89(15), С. 11083 - 11087
Опубликована: Июль 24, 2024
A
novel
approach
for
the
acylation
of
azauracil
derivatives
with
aldehydes
has
been
developed
utilizing
sodium
decatungstate
(NaDT)
as
a
photocatalyst.
This
method
demonstrates
broad
substrate
tolerance
and
yields
moderate
to
excellent
outcomes.
Notably,
it
aligns
green
chemistry
principles
by
eliminating
oxidants,
eco-friendly
energy
sources,
offering
high
scalability
operational
simplicity.
Abstract
In
light
of
the
extensive
application
fluoroalkyl‐containing
molecules
and
functionalized
quinoxalin‐2(1
H
)‐ones
in
medicinal
chemistry
functional
materials,
visible‐light‐enabled
C3‐H
fluoroalkylation
has
garnered
significant
attention.
this
review,
we
provide
a
detailed
overview
latest
advancements
rapidly
evolving
research
area.
We
cover
utilization
various
fluoroalkyl
sources
under
conditions
photocatalyst
or
without
photocatalyst,
discuss
pertinent
reaction
conditions,
mechanisms,
substrate
scope.
Our
objective
is
to
help
more
chemists
comprehend
challenges
opportunities
within
field,
thereby
fostering
its
development.
RSC Advances,
Год журнала:
2025,
Номер
15(20), С. 16183 - 16186
Опубликована: Янв. 1, 2025
An
efficient
radical
alkylative
annulation/arylation
of
N
-(arylsulfonyl)acrylamide
with
4-alkyl-1,4-dihydropyridines
(DHP)
was
developed
for
synthesizing
all-carbon
quaternary-centered
β-alkyl
amides.
Abstract
Given
the
significant
applications
of
quinoxalinones
in
medicinal,
pharmaceutical,
and
organic
chemistry,
developing
an
efficient
synthetic
approach
for
their
facile
assembly
has
received
substantial
attention
chemistry.
Conversely,
it
been
established
that
incorporating
fluorine
into
molecules
either
alters
or
enhances
physical,
chemical,
biological
properties
target
molecules.
In
this
context,
synergic
combination
medicinal
associated
with
quinoxaline‐2(1
H
)‐ones,
wide
chemical
landscape
fluorine‐containing
compounds,
installing
atom
as
a
single
di/tri‐substituted
groups
on
C‐3
position
quinoxalin‐2(1
)‐one
under
visible
light
irradiation
is
increasing
academic
scientific
interests.
mini‐review
article,
we
covered
recent
progress
achieved
various
light‐induced
direct
functionalization
)‐ones
accessing
diverse
C3‐substituted
embedded
mono/di/tri‐substituted
fluorine.
Despite
discussing
advantages,
shortcomings,
challenges
reaction
discovery,
mechanistic
rationalizations
are
also
underscored.
European Journal of Organic Chemistry,
Год журнала:
2024,
Номер
27(19)
Опубликована: Апрель 12, 2024
Abstract
A
simple
strategy
to
3‐acylated
quinoxalin‐2(1
H
)‐ones
via
a
photo‐induced
cross‐dehydrogenative
coupling
of
with
commercially
available
aldehyde
under
metal
free
conditions
without
an
external
photocatalyst
was
developed.
In
this
transformation,
various
were
generated
in
high
yields
good
functional‐group
tolerance.
The Journal of Organic Chemistry,
Год журнала:
2024,
Номер
89(15), С. 11083 - 11087
Опубликована: Июль 24, 2024
A
novel
approach
for
the
acylation
of
azauracil
derivatives
with
aldehydes
has
been
developed
utilizing
sodium
decatungstate
(NaDT)
as
a
photocatalyst.
This
method
demonstrates
broad
substrate
tolerance
and
yields
moderate
to
excellent
outcomes.
Notably,
it
aligns
green
chemistry
principles
by
eliminating
oxidants,
eco-friendly
energy
sources,
offering
high
scalability
operational
simplicity.
