Organic Letters, Год журнала: 2024, Номер unknown
Опубликована: Сен. 30, 2024
A sustainable photocatalytic approach has been established for trifluoroalkylation of isoquinoline via a three-component Minisci-type reaction using green solvent. The polarity reversal radical cascade strategy renders the selective addition an electrophilic CF
Язык: Английский
JACS Au, Год журнала: 2025, Номер unknown
Опубликована: Янв. 29, 2025
The N-heterocyclic carbene (NHC)-catalyzed umpolung of aldimines using quinoxalin-2-ones for intermolecular reactions is demonstrated. Specifically, NHC-catalyzed cross-coupling with isatins proceeds via the generation aza-Breslow intermediates by addition to C═N moiety quinoxalinones followed interception afford diverse oxindoles in moderate good yields and functional group compatibility. Moreover, detailed mechanistic studies involving isolation characterization imidoyl azoliums (oxidized form intermediates) are provided. Considering significance scaffolds bearing both quinoxalin-2-one oxindole moieties medicine natural products, synthesized molecules employing imine strategy likely find promising applications.
Язык: Английский
Процитировано
0
The Journal of Organic Chemistry, Год журнала: 2025, Номер unknown
Опубликована: Фев. 24, 2025
Pd-catalyzed photochemical reductive alkylation of quinoxalin-2(1H)-ones and dibenzoxazepines with readily available alkyl bromides has been developed. The dependence oxidative chemoselectivity on the nature base was established. A variety primary, secondary, tertiary halides have successfully employed in this transformation, which features a wide substrate scope under mild reaction conditions is also applicable to dibenzoxazepines.
Язык: Английский
Процитировано
0
European Journal of Organic Chemistry, Год журнала: 2024, Номер 27(19)
Опубликована: Апрель 12, 2024
Abstract A simple strategy to 3‐acylated quinoxalin‐2(1 H )‐ones via a photo‐induced cross‐dehydrogenative coupling of with commercially available aldehyde under metal free conditions without an external photocatalyst was developed. In this transformation, various were generated in high yields good functional‐group tolerance.
Язык: Английский
Процитировано
2
The Journal of Organic Chemistry, Год журнала: 2024, Номер 89(15), С. 11083 - 11087
Опубликована: Июль 24, 2024
A novel approach for the acylation of azauracil derivatives with aldehydes has been developed utilizing sodium decatungstate (NaDT) as a photocatalyst. This method demonstrates broad substrate tolerance and yields moderate to excellent outcomes. Notably, it aligns green chemistry principles by eliminating oxidants, eco-friendly energy sources, offering high scalability operational simplicity.
Язык: Английский
Процитировано
2
Organic Letters, Год журнала: 2024, Номер unknown
Опубликована: Сен. 30, 2024
A sustainable photocatalytic approach has been established for trifluoroalkylation of isoquinoline via a three-component Minisci-type reaction using green solvent. The polarity reversal radical cascade strategy renders the selective addition an electrophilic CF
Язык: Английский
Процитировано
2