Synthesis, Год журнала: 2024, Номер unknown

Опубликована: Июль 4, 2024

Abstract Domino reactions are essential for advancing organic synthesis. This study introduces novel thioamide-based precursors a palladium-catalyzed selective domino heteroarylation process. The method efficiently produces benzothieno[2,3-b]quinolones with yields ranging from moderate to very good. By employing aryl chlorides, the efficiency of hetero-annulation process is comparable that bromides. Executing one-pot, two-step reaction also delivered single product high selectivity. strategy involved fine-tuning substituent reactivity, utilizing electron-rich arenes, and forming metallocycles nucleophilic sulfur, consistently yielding product. proposed mechanism corroborated by mechanistic studies.

Язык: Английский