Dynamic kinetic resolution and dynamic kinetic asymmetric transformation of atropisomeric biaryls
Chem Catalysis,
Год журнала:
2025,
Номер
unknown, С. 101329 - 101329
Опубликована: Март 1, 2025
Язык: Английский
Photocatalytic Decarboxylative Alkylation of Cyclic Imine–BF3 Complexes: A Modular Route to Functionalized Azacycles
Journal of the American Chemical Society,
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 12, 2024
Alkyl
radicals
generated
via
an
acridine
photocatalyzed
decarboxylation
reaction
of
feedstock
carboxylic
acids
engage
with
a
range
cyclic
imine-BF
Язык: Английский
Palladium-catalyzed C3-alkylation of indoles with alcohols via hydrogen borrowing cascade
Tetrahedron Letters,
Год журнала:
2024,
Номер
144, С. 155155 - 155155
Опубликована: Июнь 15, 2024
Язык: Английский
Iridium-Catalyzed Enantioconvergent Construction of Piperidines and Tetrahydroisoquinolines from Racemic 1,5-Diols
Journal of the American Chemical Society,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 17, 2024
We
report
herein
a
one-step
synthesis
of
valuable
enantioenriched
piperidines
and
tetrahydroisoquinolines
from
readily
available
racemic
1,5-diols.
Key
to
the
success
is
development
new
iridacycle
catalysts
that
enable
efficient
redox-neutral
construction
two
C–N
bonds
between
diols
amines
in
an
enantioconvergent
fashion.
Mechanistic
studies
identified
intriguing
preferential
oxidation
secondary
versus
primary
alcohol
diol
substrate
by
catalyst,
which
set
challenging
intermolecular
amination
aryl–alkyl-substituted
as
enantiodetermining
step
for
this
catalytic
N-heterocycle
synthesis.
Application
method
preparation
important
drugs
bioactive
compounds
also
demonstrated.
Язык: Английский
Palladium-Catalyzed C3-Alkylation of Indoles with Alcohols Via Hydrogen Borrowing Cascade
Опубликована: Янв. 1, 2024
Indole
represents
a
privileged
scaffold
extensively
used
in
drug
design
due
to
its
promise
improve
both
binding
affinity
and
specificity
receptors.
Direct
functionalization
of
indole
framework
is
an
efficient
route
achieve
structurally
diverse
derivatives.
Herein,
highly
regio-selective
C3-alkylation
indoles
via
hydrogen
borrowing
methodology
(HBM)
has
been
established
using
alcohols
as
the
alkylation
reagents
over
pallidum
catalysis.
This
method
enables
synthesis
C3-alkylated
indoles,
demonstrating
high
group
adaptability
alcohol
substrates
(20
examples,
up
94%
yield).
Язык: Английский
Supported Nickel Nanoparticles as Catalyst in Direct sp3 C–H Alkylation of 9H‐Fluorene Using Alcohols as Alkylating Agent
Chemistry - An Asian Journal,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 14, 2024
Abstract
Herein,
we
report
an
inexpensive
first‐row
transition
metal
Ni
heterogeneous
catalytic
system
for
the
C
sp
3
‐mono
alkylation
of
fluorene
using
alcohols
as
alkylating
agents
via
borrowing
hydrogen
strategy.
The
protocol
displayed
versatility
with
high
yields
desired
products
various
types
primary
alcohols,
including
aryl/hetero
aryl
methanols,
and
aliphatic
agents.
catalyst
NPs@N−C
was
synthesized
high‐temperature
pyrolysis
strategy,
ZIF‐8
sacrificial
template.
characterized
by
XPS,
HR‐TEM,
HAADF‐STEM,
XRD
ICP‐MS.
is
stable
even
in
air
at
room
temperature,
excellent
activity
could
be
recycled
5
times
without
appreciable
loss
its
activity.
Язык: Английский