Pyruvic acid or DBU/O2 guided organophotoredox-catalyzed direct C–H alkylation/α-aminoalkylation of 1,2,4-triazine-3,5(2H,4H)-diones with amines DOI

Zhaonan Cai,

Xiaohui Cao, Hong‐Yu Zhang

и другие.

Organic Chemistry Frontiers, Год журнала: 2024, Номер 11(19), С. 5516 - 5523

Опубликована: Янв. 1, 2024

Herein, we present an organophotoredox-catalyzed direct C–H alkylation/α-aminoalkylation of 1,2,4-triazine-3,5(2 H ,4 )-diones with amines in the presence different additives. In addition, reaction mechanism were further revealed via DFT studies.

Язык: Английский

Photoinduced Metal‐/Additive‐Free Difluoromethylation of N‐Heteroaromatics† DOI Open Access
Congjun Zhu, Yangyang Shen, Tao Guo

и другие.

Chinese Journal of Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Янв. 16, 2025

Comprehensive Summary Herein, we report a photo‐induced, metal‐/additive‐free protocol for the difluoromethylation of N ‐heteroaromatics with [bis(difluoroacetoxy)iodo]benzene as reagent. The affords difluoromethylated in moderate to good yield (up 91%). transformation is compatible wide range substrates and has tolerance towards various functional groups. Moreover, synthetic value this method further demonstrated by applications gram‐scale synthesis late‐stage functionalization biologically important molecules.

Язык: Английский

Процитировано

0
Silver‐Catalyzed Decarboxylative Coupling of Oxamic Acids with Styrenes to Synthesize E‐Cinnamamides: A Distinguish Reaction Pathway DOI Creative Commons

A Ru‐Han,

Yong‐Wang Huo,

Xiao‐Feng Wu

и другие.

ChemistryOpen, Год журнала: 2025, Номер unknown

Опубликована: Янв. 29, 2025

Abstract A silver‐catalyzed decarboxylative coupling of oxamic acids with styrenes has been developed to produce E ‐cinnamamides. Oxamic act as efficient precursors for carbamoy radicals. Based on the mechanistic experiments and intermediate analysis, proposed mechanism involves radical addition styrenes, followed by oxidation solvent participation, ultimately leading formation cinnamamides which is different from reported cases.

Язык: Английский

Процитировано

0
The organophotocatalytic trifluoromethylation of 6-azauracils DOI Creative Commons

Krishna Kanta Das,

Alakananda Hajra

RSC Advances, Год журнала: 2025, Номер 15(15), С. 11370 - 11376

Опубликована: Янв. 1, 2025

Herein, we have developed an organophotocatalytic trifluoromethylation of 6-azauracils using inexpensive Langlois reagent to prepare a variety trifluoromethylated azauracil derivatives under ambient air condition.

Язык: Английский

Процитировано

0
Photocatalyzed Acylation of Azauracil Derivatives with Aldehydes DOI
Yi Wang, Lianghong Liu,

Peng Deng

и другие.

The Journal of Organic Chemistry, Год журнала: 2024, Номер 89(15), С. 11083 - 11087

Опубликована: Июль 24, 2024

A novel approach for the acylation of azauracil derivatives with aldehydes has been developed utilizing sodium decatungstate (NaDT) as a photocatalyst. This method demonstrates broad substrate tolerance and yields moderate to excellent outcomes. Notably, it aligns green chemistry principles by eliminating oxidants, eco-friendly energy sources, offering high scalability operational simplicity.

Язык: Английский

Процитировано

0
Pyruvic acid or DBU/O2 guided organophotoredox-catalyzed direct C–H alkylation/α-aminoalkylation of 1,2,4-triazine-3,5(2H,4H)-diones with amines DOI

Zhaonan Cai,

Xiaohui Cao, Hong‐Yu Zhang

и другие.

Organic Chemistry Frontiers, Год журнала: 2024, Номер 11(19), С. 5516 - 5523

Опубликована: Янв. 1, 2024

Herein, we present an organophotoredox-catalyzed direct C–H alkylation/α-aminoalkylation of 1,2,4-triazine-3,5(2 H ,4 )-diones with amines in the presence different additives. In addition, reaction mechanism were further revealed via DFT studies.

Язык: Английский

Процитировано

0