Hexafluoroisopropanol (HFIP)-Mediated Intramolecular Cyclization of Allenamides To Access C1-Vinyl Tetrahydro-β-carbolines DOI

Dhananjay Chaudhary,

Malleswara Rao Kuram

The Journal of Organic Chemistry, Год журнала: 2024, Номер 89(16), С. 11783 - 11788

Опубликована: Июль 26, 2024

The construction of biologically interesting N-heterocycles under metal-free conditions is a constant goal in industry and academia. Herein, we have developed an hexafluoroisopropanol (HFIP)-mediated intramolecular cyclization allenamides, providing tetrahydro-β-carboline derivatives embedded with C1-vinyl functionality. protocol provided atom-efficiently room temperature broad substrate scope good to excellent yields. potential impact the further highlighted by synthesizing important molecules diversified scaffolds via postsynthetic modifications.

Язык: Английский

Hydro-phosphorothiolation of Styrene and Cyclopropane with S-Hydrogen Phosphorothioates under Ambient Conditions DOI

Biswajit Sarkar,

Alakananda Hajra

Organic Letters, Год журнала: 2024, Номер 26(24), С. 5141 - 5145

Опубликована: Июнь 7, 2024

A metal-free hexafluoroisopropanol-mediated hydro-phosphorothiolation of styrenes and donor-acceptor cyclopropanes with

Язык: Английский

Процитировано

7

HFIP-Mediated Cascade Aminomethylation and Intramolecular Cyclization of Allenamides with N,O-Acetals to Access Tetrahydro-β-carboline Derivatives DOI

Dhananjay Chaudhary,

Chandra Kant Maurya,

Urmila Unnikrishnan

и другие.

Chemical Communications, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

A cascade of two C–C bond forming reactions promoted alone by HFIP is described delivering tetrahydro-β-carboline derivatives embedded with an allylic amine functionality.

Язык: Английский

Процитировано

0

Research Progress of Homogeneous Catalytic Reactions of Hexafluoroisopropanol (HFIP) DOI Creative Commons
Huiying Xu, Hongyuan Luo, Yi Wang

и другие.

Tetrahedron Green Chem, Год журнала: 2025, Номер 5, С. 100071 - 100071

Опубликована: Фев. 27, 2025

Язык: Английский

Процитировано

0

Hexafluoroisopropanol (HFIP)-Mediated Intramolecular Cyclization of Allenamides To Access C1-Vinyl Tetrahydro-β-carbolines DOI

Dhananjay Chaudhary,

Malleswara Rao Kuram

The Journal of Organic Chemistry, Год журнала: 2024, Номер 89(16), С. 11783 - 11788

Опубликована: Июль 26, 2024

The construction of biologically interesting N-heterocycles under metal-free conditions is a constant goal in industry and academia. Herein, we have developed an hexafluoroisopropanol (HFIP)-mediated intramolecular cyclization allenamides, providing tetrahydro-β-carboline derivatives embedded with C1-vinyl functionality. protocol provided atom-efficiently room temperature broad substrate scope good to excellent yields. potential impact the further highlighted by synthesizing important molecules diversified scaffolds via postsynthetic modifications.

Язык: Английский

Процитировано

3