Oxyphosphorodithiolation of Vinyl Azides with P4S10 and Alcohols Leading to β-Keto Phosphorodithioates DOI

Jian Huang,

Chao Ma, Jian Sun

и другие.

The Journal of Organic Chemistry, Год журнала: 2024, Номер 89(24), С. 18384 - 18392

Опубликована: Дек. 10, 2024

A simple strategy for the synthesis of β-keto phosphorodithioates has been developed through direct oxyphosphorodithiolation vinyl azides with P

Язык: Английский

Visible Light/Copper Catalysis-Enabled Arylation and Alkenylation of Phosphorothioates via Site-Selective C–H Thianthrenation DOI

Guoju Guo,

Jie Ma,

Yuzhen Dong

и другие.

Organic Letters, Год журнала: 2024, Номер unknown

Опубликована: Сен. 24, 2024

An efficient visible light/copper-enabled arylation and alkenylation of phosphorothioates with thianthrenium salts via a C(sp

Язык: Английский

Процитировано

5
Synthesis of S-alkyl phosphorothioates/phosphorodithioates via ring-opening reaction of sulfonium salts with S8, H-phosphonates or P4S10, and alcohols DOI
Lihua Yang, Lin Chen,

Bei Li

и другие.

Organic Chemistry Frontiers, Год журнала: 2024, Номер 11(20), С. 5731 - 5740

Опубликована: Янв. 1, 2024

A simple and practical method for the synthesis of S -alkyl phosphorothioates/phosphorodithioates through three-component reaction cyclic sulfonium salts with 8 , H -phosphonates, or P 4 10 alcohols was readily developed.

Язык: Английский

Процитировано

4
Visible-Light-Induced Phosphorothioation of Alkenyl Sulfonium Salts with S8 and H-Phosphonates DOI
Lihua Yang,

Ni-Dan Meng,

Li Tang

и другие.

The Journal of Organic Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Фев. 4, 2025

An efficient and practical method for synthesizing vinyl phosphorothioates has been demonstrated through a visible-light-induced three-component reaction of alkenyl sulfonium salts, S8, H-phosphonates. This facilitates the synthesis diverse range with wide substrate scope functional group tolerance. Preliminary mechanistic studies suggest that involves phosphorothioate radical-triggered process.

Язык: Английский

Процитировано

0
1,2-Acylphosphinylation of Styrenes to Access β-Aryl-γ-ketophosphine Oxides by Irradiation-Induced Radical Relay DOI
Dengyu Yin,

Lishuai Lu,

Yandong Dou

и другие.

The Journal of Organic Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Март 11, 2025

An acylphosphinylation reaction has been devised for the synthesis of β-aryl-γ-ketophosphine oxides, employing styrenes and acyl azolium salts through an irradiation-induced radical relay mechanism. This method effectively constructs C–C C–P bonds while demonstrating excellent functional group tolerance. Mechanistic studies revealed that a radical-addition–coupling–elimination cascade process was involved in this reaction.

Язык: Английский

Процитировано

0
HFIP-Promoted Regioselective Hydrofunctionalization of Enamides and N-Vinyl Azoles DOI

Susanta Patra,

Satyajit Samanta,

Vishal Talukdar

и другие.

The Journal of Organic Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Апрель 29, 2025

An efficient and regioselective method for the intermolecular hydrofunctionalization of enamides N-vinyl azoles has been developed, enabling formation diverse C-S, C-O, C-N, C-C bonds. This transition-metal-free, additive-free, Brønsted acid-free protocol employs hexafluoroisopropanol (HFIP) as sole reagent, which plays a dual role: iminium carbocation intermediate facilitating nucleophile generation through its hydrogen-bonding network. The reaction demonstrates exceptional substrate versatility, accommodating thiophenols, alcohols, heterocyclic amines, well NH-free indoles, pyrroles, carbazoles nucleophiles, proceeding via Markovnikov-selective pathway. is general simple with broad compatibility.

Язык: Английский

Процитировано

0
Dual Photoredox/Copper‐Catalyzed 1,2‐Diphosphorothiolation of Alkenes with P(O)SH Compounds to Access Vicinal Bisphosphorothioates DOI

Pengbo Zhang,

Longyu Wang, Xinyi Guo

и другие.

Chinese Journal of Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Май 12, 2025

Comprehensive Summary An efficient photoredox/copper dual‐catalyzed 1,2‐diphosphorothiolation of alkenes with P(O)SH compounds was realized under oxidative conditions. In this transformation, acted as both the phosphorothioate radical source and coupling partner. A wide range valuable vicinal bisphosphorothioates can be easily constructed starting from simple raw materials in a step‐ atom‐economical manner. Notably, reaction system has been successfully used to incorporate two groups into many drug molecules, highlighting substantial synthetic potential protocol.

Язык: Английский

Процитировано

0
Synthesis of Unsymmetrical Phosphorus Disulfides DOI Creative Commons

Jeffrey Ash,

Jun Yong Kang

Organic & Biomolecular Chemistry, Год журнала: 2024, Номер 22(36), С. 7492 - 7499

Опубликована: Янв. 1, 2024

A sulfur-mediated umpolung strategy employing

Язык: Английский

Процитировано

0
New Frontiers in Phosphorothioate Formation: Harnessing Inorganic Phosphorus Sources DOI
Jiawei He,

Xuesi Zhou,

Zixuan Wan

и другие.

Chemical Communications, Год журнала: 2024, Номер 60(99), С. 14691 - 14702

Опубликована: Янв. 1, 2024

This review highlights the latest advancements in synthesis of phosphorothioates and their derivatives from inorganic phosphorus sources, focusing on applicability, mechanisms, current limitations, potential future directions.

Язык: Английский

Процитировано

0
Oxyphosphorodithiolation of Vinyl Azides with P4S10 and Alcohols Leading to β-Keto Phosphorodithioates DOI

Jian Huang,

Chao Ma, Jian Sun

и другие.

The Journal of Organic Chemistry, Год журнала: 2024, Номер 89(24), С. 18384 - 18392

Опубликована: Дек. 10, 2024

A simple strategy for the synthesis of β-keto phosphorodithioates has been developed through direct oxyphosphorodithiolation vinyl azides with P

Язык: Английский

Процитировано

0