Vinylogous functionalization of 4-alkylidene-5-aminopyrazoles with methyl trifluoropyruvates

Beilstein Journal of Organic Chemistry, Год журнала: 2025, Номер 21, С. 533 - 540

Опубликована: Март 10, 2025

A valuable vinylogous addition reaction between 4-alkylidene-5-aminopyrazoles and alkyl trifluoropyruvates leading to highly functionalized tertiary alcohols bearing a trifluoromethyl group pyrazole ring is presented. The corresponding are obtained in moderate good yields (up 80%) high diastereoselectivity 7:1).

Язык: Английский

Asymmetric electrophilic functionalization of amino-substituted heteroaromatic compounds: a convenient tool for the enantioselective synthesis of nitrogen heterocycles.

Chemical Communications, Год журнала: 2024, Номер unknown

Опубликована: Янв. 1, 2024

The catalytic asymmetric electrophilic functionalization of the less reactive N-heteroaromatic compounds has been reported using approach introduction an exocyclic amino substituent.

Язык: Английский

Recent advances in the catalytic asymmetric construction of axially chiral azole-based frameworks

Organic Chemistry Frontiers, Год журнала: 2024, Номер 11(23), С. 6819 - 6849

Опубликована: Янв. 1, 2024

This review highlights recent advances in the atroposelective preparation of axially chiral azole derivatives, emphasizing mechanistic insights and synthetic applications development this class five-membered heterocyclic frameworks.

Язык: Английский