Vinylogous functionalization of 4-alkylidene-5-aminopyrazoles with methyl trifluoropyruvates

Beilstein Journal of Organic Chemistry, Journal Year: 2025, Volume and Issue: 21, P. 533 - 540

Published: March 10, 2025

A valuable vinylogous addition reaction between 4-alkylidene-5-aminopyrazoles and alkyl trifluoropyruvates leading to highly functionalized tertiary alcohols bearing a trifluoromethyl group pyrazole ring is presented. The corresponding are obtained in moderate good yields (up 80%) high diastereoselectivity 7:1).

Language: Английский

Asymmetric electrophilic functionalization of amino-substituted heteroaromatic compounds: a convenient tool for the enantioselective synthesis of nitrogen heterocycles.

Chemical Communications, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

The catalytic asymmetric electrophilic functionalization of the less reactive N-heteroaromatic compounds has been reported using approach introduction an exocyclic amino substituent.

Language: Английский

Recent advances in the catalytic asymmetric construction of axially chiral azole-based frameworks

Organic Chemistry Frontiers, Journal Year: 2024, Volume and Issue: 11(23), P. 6819 - 6849

Published: Jan. 1, 2024

This review highlights recent advances in the atroposelective preparation of axially chiral azole derivatives, emphasizing mechanistic insights and synthetic applications development this class five-membered heterocyclic frameworks.

Language: Английский