Progress in Radical Fluorosulfonyl Reagents DOI
Yi Wang,

Heyin Li

Synthesis, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 11, 2024

Abstract Sulfur(VI) fluoride exchange (SuFEx) chemistry that relies on the unique reactivity–stability balance of high valent organosulfur has emerged as a promising topic for next-generation click reaction. Sulfonyl fluorides are most widely used connective hubs SuFEx reaction with widespread applications in fields chemical biology, drug discovery, and materials science. Compared current methods, direct fluorosulfonylation fluorosulfonyl radicals concise efficient approach production sulfonyl fluorides. The highly active SO2F radical was an unstable inaccessible precursor until it observed decomposition azide, which inspired efforts towards precursors processes. This review presents discusses breakthroughs generation from various precursors, well their application synthesis diverse functionalized 1 Introduction 2 FSO2Cl Radical Precursor 3 Benzimidazolium Fluorosulfonates Precursors 4 Alk-1-ynylsulfonyl Fluorides 5 (Diarylmethylene)sulfamoyl 6 Vinyl Fluorosulfates 7 Conclusion Outlook

Язык: Английский

Cyano-Fluorosulfonylation of Unactivated Alkenes by Photoredox and Copper Dual Catalysis DOI
Rongbiao Wei, Yao Huang, Oleg I. Afanasyev

и другие.

Organic Letters, Год журнала: 2024, Номер 26(42), С. 9132 - 9137

Опубликована: Окт. 16, 2024

Both fluorosulfonyl and cyano groups are important structural motifs in bioactive molecules. Herein, we report a new difunctionalization reaction of alkenes based on radicals, which allows for the introduction into unactivated one step. This transformation is enabled by merging photoredox copper catalysis, featuring visible light mild conditions, good functional group tolerance. Further products via SuFEx reactions also demonstrated.

Язык: Английский

Процитировано

0
Water-accelerated single-electron transfer aquaphotocatalysis for open-chain SuFEx hubs DOI Creative Commons

Byeong Jun Koo,

Yonghwan Kwon,

Ah Hyeon Son

и другие.

Cell Reports Physical Science, Год журнала: 2024, Номер 5(11), С. 102279 - 102279

Опубликована: Ноя. 1, 2024

Язык: Английский

Процитировано

0
Progress in Radical Fluorosulfonyl Reagents DOI
Yi Wang,

Heyin Li

Synthesis, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 11, 2024

Abstract Sulfur(VI) fluoride exchange (SuFEx) chemistry that relies on the unique reactivity–stability balance of high valent organosulfur has emerged as a promising topic for next-generation click reaction. Sulfonyl fluorides are most widely used connective hubs SuFEx reaction with widespread applications in fields chemical biology, drug discovery, and materials science. Compared current methods, direct fluorosulfonylation fluorosulfonyl radicals concise efficient approach production sulfonyl fluorides. The highly active SO2F radical was an unstable inaccessible precursor until it observed decomposition azide, which inspired efforts towards precursors processes. This review presents discusses breakthroughs generation from various precursors, well their application synthesis diverse functionalized 1 Introduction 2 FSO2Cl Radical Precursor 3 Benzimidazolium Fluorosulfonates Precursors 4 Alk-1-ynylsulfonyl Fluorides 5 (Diarylmethylene)sulfamoyl 6 Vinyl Fluorosulfates 7 Conclusion Outlook

Язык: Английский

Процитировано

0